DIFFUSION-WEIGHTED MRI IN THE DIFFERENTIAL DIAGNOSIS OF BRAIN MENINGIOMAS

Methods of diffusion-weighted magnetic resonance imaging (DW MRI) provides information on the microstructural state of various tissues and organs. Also, a diffusion-weighted image (DWI) obtained using DW MRI applied to the differential diagnosis of benign and malignant tumors. Purpose – to compare the values obtained ADC meningiomas with cell density and proliferative activity index Ki67 tumor. Material and methods. The study included DW MRI program with 37 patients for brain meningiomas. ADC was calculated on DWI with a maximum diameter of meningioma, in the area of interest have not been included cystic and necrotic areas of the tumor. When meningiomas morphological study assessed the degree of malignancy according to WHO classification, the index of Ki67 proliferative activity and cell density in tumor tissue. Results. In most typical cases detected (MI) and atypical (MII) meningiomas – at 37.8 % and 56.7 % of patients, respectively. Anaplastic (MIII) meningioma verified in 5.5 % of patients. The average value for meningiomas ADC MI was 1375,5 ± 197,5 mm2 /s. ADC for meningiomas MII and MIII costavili 1113.1 ± 180 mm2 /sec and 689 ± 31.1 mm2 /s, respectively. Statistically significant differences between the mean values obtained by comparing ADC meningiomas MI and MIII (p=0.008) and meningiomas MII and MIII (p=0.012). No significant differences between the cell density was not detected meningiomas (p=0,834, p=0,684 p=0,766 respectively for the MI/MII, MII/MIII and MI/MIII). Statistically significant differences between the values of Ki67 index were found when comparing the groups meningiomas MI and MIII (p=0.002) and MII and MIII (p=0.007). ADC between index values and proliferative activity of Ki67, expressed marked correlation (r=-0,699, p=0,001). Conclusion. DW MRI and ADC maps can be used as an additional non-invasive method of differential diagnosis brain meningioma gradation. 

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