POLYSACCHARIDES TUSSILAGOFARFARA L. REDUCE MYELOSUPPRESSION INDUCED BY CISPLATIN AND ETOPOSIDE
https://doi.org/10.21294/1814-4861-2017-16-4-42-48
Abstract
The purpose of the study was to investigate the influence of polysaccharides Tussilagofarfara L. on erythroid sprout hematopoiesis, tumor growth and metastasis in mice with Lung cancer-67 during therapy with cisplatin and etoposide. It was found that the use of polysaccharides reduces myelosuppression induced by cytostatics of erythroidal sprout hematopoiesis and leads to increase anti-tumor and anti-metastatic effect of chemotherapy.
About the Authors
E. A. Safonova
Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences.
Russian Federation
Russian Federation
Safonova Elena A., PhD, Research Scientist, Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences.
3, Lenina avenue, 634028-Tomsk, Russia.
K. A. Lopatina
Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences; National Research Tomsk State University.
Russian Federation
Russian Federation
Lopatina Ksenija A., PhD, Research Scientist, Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences.
3, Lenina avenue, 634028-Tomsk, Russia.
T. G. Razina
Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences.
Russian Federation
Russian Federation
Razina Tatjana G., DSc, Senior Researcher, Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences.
3, Lenina avenue, 634028-Tomsk, Russia.
E. P. Fedorova
Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences.
Russian Federation
Russian Federation
Fedorova Elena P., PhD, Research Scientist, Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences.
3, Lenina avenue, 634028-Tomsk, Russia.
E. P. Zueva
Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences.
Russian Federation
Russian Federation
Zueva Elena P., DSc, Professor, Head of the laboratory oncopharmacology, Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences.
3, Lenina avenue, 634028-Tomsk, Russia.
A. M. Gurev
Siberian State Medical University.
Russian Federation
Russian Federation
Gurev Artem M., DSc, Siberian State Medical University.
2, Moskovskiy Tract, 634050-Tomsk, Russia.
M. V. Belousov
Siberian State Medical University.
Russian Federation
Russian Federation
Belousov Mihail V.,DSc, Professor, Siberian State Medical University.
2, Moskovskiy Tract, 634050-Tomsk, Russia.
References
1. Pokrovskiy V.S., Treshchalina E.M., Bychkov M.B. Prospects for the development of combined chemotherapy for disseminated non-small cell lung cancer. Russian biotherapeutic journal. 2009; 8 (3): 61–68. [in Russian]
2. Mashkovskiy M.D. Drugs. Moscow, 2008; 1206. [in Russian]
3. Ptushkin V.V. Improvements in maintenance therapy with cytotoxic agents. Modern oncology. 2002; 4 (2): 28–30. [in Russian]
4. Safonova E.A., Lopatina K.A., Razina T.G., Fodorova Е.P., Pahomova А.V., Vichuzanina А.V., Efimova L.А. Correction of the toxic effect of paclitaxel on the blood system and epithelium of the small intestine with water-soluble polysaccharides of Tussilago farfara. Acorus calamus and echinacea purpurea. Russian biotherapeutic journal. 2010; 2 (9): 19–23. [in Russian]
5. The European Directive 2010/63. EU and the Council of the European Union on the protection of animals used for scientific purposes (translated from English). Saint-Petersburg, 2012; 48. [in Russian]
6. Khabriev R.U., Verstakova O.L., Arzamastsev Е.V.,Babayan E.А., Belousov Yu.B., Bulaev V.М., Ershov F.I. Manual on experimental (preclinical) study of new pharmacological substances. Moscow, 2005; 832. [in Russian]
7. Korz А.P., Guriev А.М., Belousova М.V., Usubov М.S., Belyanin М.L. Determination of the content of uronic acids in the polysaccharide complex of Tussilago farfara. Bulletin PGFA. 2010; 7: 95–97. [in Russian]
8. Korz А.P., Guriev А.М., Belousova М.V., Usubov М.S., Belyanin М.L. Monosaccharide composition of polysaccharide complex of Tussilago farfara leaves. Bulletin of Siberian Medicine. 2011; 5: 62–65. [in Russian]
9. Goldberg E.D., Dygaj A.M., Shakhov V.P. Methods of tissue culture in hematology. Tomsk, 1992; 264. [in Russian]
10. Lakin G.F. Biometry. Moscow, 1980; 293. [in Russian]
11. Chen Y., Zhu B., Zhang L., Yan S., Li J. Experimental Study of the Bone Marrow protective Effect of a Traditional Chinese Compound Preparation. Phytother Res. 2009; 23: 823–826. doi: 10.1002/ptr.2678.
12. Shchepetkin I.A. Activation of macrophages by plant polysaccharides. Antibiotics and Chemotherepy. 2004; 49 (1): 35–42. [in Russian]
Review
For citations:
Safonova E.A., Lopatina K.A., Razina T.G., Fedorova E.P., Zueva E.P., Gurev A.M., Belousov M.V. POLYSACCHARIDES TUSSILAGOFARFARA L. REDUCE MYELOSUPPRESSION INDUCED BY CISPLATIN AND ETOPOSIDE. Siberian journal of oncology. 2017;16(4):42-48. (In Russ.) https://doi.org/10.21294/1814-4861-2017-16-4-42-48
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