ИММУНОТЕРАПИЯ МЕЛАНОМЫ
Аннотация
Меланома – это одна из наиболее опасных злокачественных опухолей человека. Агрессивный характер роста с риском формирования отдаленных метастазов является причиной высокого уровня смертности от меланомы кожи во всем мире. Ограниченные возможности таких методов, как хирургия, химиотерапия и лучевая терапия, делают актуальной разработку более эффективных способов лечения. В настоящее время одним из привлекательных подходов для борьбы с опухолевыми клетками является иммунотерапия. В обзоре проанализированы основные направления иммунотерапии меланомы, в том числе подходы в области создания терапевтических вакцин на основе опухолевых клеток, синтетических пептидов и полиэпитопных иммуногенов.
Ключевые слова
меланома,
иммунотерапия,
антигены,
клеточные вакцины,
пептидные вакцины,
ДНК-вакцины,
дендритные клетки
Об авторах
Е. А. Боробова
Сибирский федеральный биомедицинский исследовательский центр им. акад. Е.Н. Мешалкина; ФБУН «Государственный научный центр вирусологии и биотехнологии «Вектор».
Россия
Россия
Боробова Елена Александровна - врач клинической лабораторной диагностики, Сибирский федеральный биомедицинский исследовательский центр им. акад. Е.Н. Мешалкина; младший научный сотрудник, ФБУН ГНЦ ВБ «Вектор».
630055, г. Новосибирск, ул. Речкуновская, 15.
А. А. Жеравин
Сибирский федеральный биомедицинский исследовательский центр им. акад. Е.Н. Мешалкина.
Россия
Россия
Жеравин Александр Александрович, кандидат медицинских наук, руководитель центра онкологии и радиотерапии, Сибирский федеральный биомедицинский исследовательский центр им. акад. Е.Н. Мешалкина.
630055, г. Новосибирск, ул. Речкуновская, 15.
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Для цитирования:
Боробова Е.А., Жеравин А.А. ИММУНОТЕРАПИЯ МЕЛАНОМЫ. Сибирский онкологический журнал. 2017;16(4):65-75. https://doi.org/10.21294/1814-4861-2017-16-4-65-75
For citation:
Borobova E.A., Zheravin A.A. IMMUNOTHERAPY FOR MELANOMA. Siberian journal of oncology. 2017;16(4):65-75. (In Russ.) https://doi.org/10.21294/1814-4861-2017-16-4-65-75
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