RADIOTHERAPY IN MANAGEMENT OF BRCA-POSITIVE OVARIAN CANCER
https://doi.org/10.21294/1814-4861-2017-16-4-103-107
Abstract
Cancer cells with the loss of BRCA 1 or BRCA 2 function are unable to repair DNA double-strand breaks and demonstrate the increased sensitivity to various DNA-damaging agents. We aimed to describe successful treatment outcomes in two patients with BRCA1-associated ovarian cancer, who showed a complete clinical response to radiotherapy in combination with platinum-based chemotherapy. The progression-free survival was 11 months in one case and 8 months in another case.
About the Authors
T. V. Gorodnova
N.N. Petrov Research Institute of Oncology, Saint-Petersburg.
Russian Federation
Russian Federation
Gorodnova Tatiana V., MD, PhD, Research Fellow, Department of Gynecological Oncology, N.N. Petrov Research Institute of Oncology.
68, Leningradskaya Street, 197758-Saint-Petersburg, Russia.
S. B. Baranov
N.N. Petrov Research Institute of Oncology, Saint-Petersburg.
Russian Federation
Russian Federation
Baranov Sergey B., MD, PhD, Research Fellow, Department of Radiation Therapy, N.N. Petrov Research Institute of Oncology.
68, Leningradskaya Street, 197758-Saint-Petersburg, Russia.
L. N. Shevkunov
N.N. Petrov Research Institute of Oncology, Saint-Petersburg.
Russian Federation
Russian Federation
Shevkunov Lev N., MD, PhD, Radiologist, Diagnostic Imaging Department, N.N. Petrov Research Institute of Oncology.
68, Leningradskaya Street, 197758-Saint-Petersburg, Russia.
S. A. Tyatkov
N.N. Petrov Research Institute of Oncology, Saint-Petersburg.
Russian Federation
Russian Federation
Tyatkov Stanislav A., MD, Radiologist, Diagnostic Imaging Department, N.N. Petrov Research Institute of Oncology.
68, Leningradskaya Street, 197758-Saint-Petersburg, Russia.
A. P. Sokolenko
N.N. Petrov Research Institute of Oncology, Saint-Petersburg.
Russian Federation
Russian Federation
Sokolenko Anna P., MD, PhD, Research Fellow, Laboratory of Molecular Oncology, N.N. Petrov Research Institute of Oncology.
68, Leningradskaya Street, 197758-Saint-Petersburg, Russia.
C. B. Kotiv
N.N. Petrov Research Institute of Oncology, Saint-Petersburg.
Russian Federation
Russian Federation
Kotiv Christina B., Postgraduate, Department of Gynecological Oncology, N.N. Petrov Research Institute of Oncology.
68, Leningradskaya Street, 197758-Saint-Petersburg, Russia.
E. N. Imyanitov
N.N. Petrov Research Institute of Oncology, Saint-Petersburg.
Russian Federation
Russian Federation
Imyanitov Evgeny N., MD, PhD, Professor, Head of Laboratory of Molecular Oncology, N.N. Petrov Research Institute of Oncology.
68, Leningradskaya Street, 197758-Saint-Petersburg, Russia.
I. V. Berlev
N.N. Petrov Research Institute of Oncology, Saint-Petersburg.
Russian Federation
Russian Federation
Berlev Igor V., MD, PhD, Professor, Head of Gynecological Oncology Department, N.N. Petrov Research Institute of Oncology.
68, Leningradskaya Street, 197758-Saint-Petersburg, Russia.
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Review
For citations:
Gorodnova T.V., Baranov S.B., Shevkunov L.N., Tyatkov S.A., Sokolenko A.P., Kotiv C.B., Imyanitov E.N., Berlev I.V. RADIOTHERAPY IN MANAGEMENT OF BRCA-POSITIVE OVARIAN CANCER. Siberian journal of oncology. 2017;16(4):103-107. (In Russ.) https://doi.org/10.21294/1814-4861-2017-16-4-103-107
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