CYTOKINE GENE POLYMORPHISMS AS PREDICTORS OF CHRONIC PAIN SYNDROME IN ONCOLOGY
https://doi.org/10.21294/1814-4861-2017-16-5-87-94
Abstract
The literature review on the role of cytokine gene polymorphisms in the development of chronic pain in cancer patients was presented using MedLine, PubMed, NEB elibrary.ru, WileyOnlineLibrary, WebofScience, OxfordUniversityPress and SAGEPremier databases for years 1995 to 2016. The role of inter-individual differences based on cytokine gene polymorphisms and their receptors for personalized anesthetic and accompanying treatment in oncology was shown.
About the Authors
O. P. Bobrova
V.F. Voyno-Jasenetsky Krasnoyarsk State Medical University; Krasnoyarsk Regional Clinical Oncology Dispensary named after A.I. Kryzhanovsky
Russian Federation
Russian Federation
MD, PhD, Associated Professor, Department of Pharmacology with Courses of Clinical Pharmacology, Pharmaceutical Technology
SPIN-code: 3525-8218
1, Partizana Zheleznyaka Str., 660022-Krasnoyarsk
16, 1-st Smolenskaya str., 660133-Krasnoyarsk
N. A. Shnayder
V.F. Voyno-Jasenetsky Krasnoyarsk State Medical University
Russian Federation
Russian Federation
MD, DSc, Professor, Head of the Department of Medical Genetics and Clinical Neurophysiology
SPIN-code: 433-1627
1, Partizana Zheleznyaka Str., 660022-Krasnoyarsk
M. M. Petrova
V.F. Voyno-Jasenetsky Krasnoyarsk State Medical University
Russian Federation
Russian Federation
MD, DSc, Professor, Head of the Outpatient Department
SPIN-code: 449-1320.
1, Partizana Zheleznyaka Str., 660022-Krasnoyarsk
K. S. Zyryanov
Russian National Research Medical University named after N.I. Pirogov
Russian Federation
Russian Federation
MD, DSc, Professor, Head of the Department of General and Clinical Pharmacology of the Peoples’ Friendship University of Russia; Deputy Chief Physician for Therapy
SPIN-code: 2725-9981.
6, Miklukho-Maklaya Str., 117198-Moscow
D. A. Sychev
Russian Medical Academy of Continuing Professional Education
Russian Federation
Russian Federation
MD, DSc, Professor, Member of the Russian Academy of Sciences, Head of the Department of Clinical Pharmacology and therapeutic
SPIN-code: 4525-7556.
2/1, Barrikadnaya Str., 125993-Moscow
References
1. Mikaelyan M.F., Adzhienko V.L. Current concepts in management of chronic pain syndrome. Medicinal Herald. 2016; 2(62): 28–30. [in Russian]
2. Yakhno N.N., Kukushkina M.L. Pain (Guide for physicians). Moscow, 2011. 512. [in Russian].
3. Balashova T.V., Andreeva N.A., Mnatsakanyani L.A., Kotelnikova A.G., Dolgunov A.M. Current concepts of pain pathogenesis. Pacifiс Ocean Medical Journal. 2012; 3: 13–16. [in Russian] 4. Wang X.B., Li Y.S., Li J., Han Y., Liu Z.D. Interleukin-8 -251A/T gene polymorphism and lung cancer susceptibility: a meta-analysis. J Cell Mol Med. 2015 Jun; 19 (6): 1218–22. doi: 10.1111/jcmm.12466.
4. Schmidt B.L., Hamamoto D.T., Simone D.A., Wilcox G.L. Mechanisms of cancer pain. J Mol Interv. 2010; 10 (3): 164–78. doi: 10.1124/mi.10.3.7.
5. Yoneda T., Hata K., Nakanishi M., Nagae M., Nagayama T., Wakabayashi H., Nishisho T., Sakurai T., Hiraga T. Involvement of acidic microenvironment in the pathophysiology of cancer-associated bone pain. Bone. 2011; 48 (1): 100–5. doi: 10.1016/j.bone.2010.07.009.
6. Grivennikov S.I., Greten F.R., Karin M. Immunity, inflammation, and cancer. Cell. 2010; 140(6): 88399. doi: 10.1016/j.cell.2010.01.025.
7. Matveeva L.V., Mosina L.M. The role of cytokines of the interleukin-1 family in gastric carcinogenesis. Newsletter of RAMS. 2012; 11: 59–65. [in Russian]
8. Branford R., Droney J., Ross J.R. Opioid genetics: the key to personalized pain control? Clin Genet. 2012; 82: 301–310. doi: 10.1111/j.1399- 0004.2012.01923.x.
9. Neeb L., Hellen P., Boehnke C., Hoffmann J., Schuh-Hofer S., Dirnagl U., Reuter U. IL-1beta stimulates COX-2 dependent PGE synthesis and CGRP release in rat trigeminal ganglia cells. PLoS One. 2011; 6 (3): e17360. doi: 10.1371/journal.pone.0017360.
10. Hirata H., Tetsumoto S., Kijima T., Kida H., Kumagai T., Takaha-shi R., Otani Y., Inoue K., Kuhara H., Shimada K., Nagatomo I., Takeda Y., Goya S., Yoshizaki K., Kawase I., Tachibana I., Kishimoto T., Kumanogoh A. Favorable responses to tocilizumab in two patients with cancer – related cachexia. J Pain Symptom Manage. 2013; 46 (2): e9–e13. doi: 10.1016/j.jpainsymman.2013.01.009.
11. Wang X.M., Lehky T.J., Brell J.M., Dorsey S.G. Discovering cytokines as targets for chemotherapy-induced painful peripheral neuropathy. Cytokine. 2012; 59 (1): 3–9. doi: 10.1016/j.cyto.2012.03.027.
12. Guo G., Gao F. CXCR3: latest evidence for the in volvemen to chemokine signaling in bone cancer pain. Exp Neurol. 2015; 265: 1769. doi:10.1016/j.expneurol.2015.02.003.
13. Vendrell D., Macedo I., Alho M., Dionísio R., Costa L. Treatment of cancer pain by targeting cytokines. Mediators Inflamm. 2015; 2015: 984570. doi: 10.1155/2015/984570.
14. Jaggi A.S., Singh N. Mechanisms in cancer-chemotherapeutic drugs-induced peripheral neuropathy. Toxicology. 2012; 291 (1–3): 1–9. doi: 10.1016/j.tox.2011.10.019.
15. Saijo Y., Tanaka M., Miki M., Usui K., Suzuki T., Maemondo M., Hong X., Tazawa R., Kikuchi T., Matsushima K., Nukiwa T. Proinflammatory cytokine IL-1 beta promotes tumor growth of Lewis lung carcinoma by induction of angiogenic factors: in vivo analysis of tumor-stromal interaction. J Immunol. 2002; 169: 469–475.
16. Kiguchi N., Kobayashi Y., Kishioka S. Chemokine and cytokines in neuroinflammation leading to neuropathic pain. Curr Opin Pharmacol. 2012; 12 (1): 55–61. doi: 10.1016/j.coph.2011.10.007.
17. Guan X.H., Fu Q.C., Shi D., Bu H.L., Song Z.P., Xiong B.R., Shu B., Xiang H.B., Xu B., Manyande A., Cao F., Tian Y.K. Activation of spinal chemokine receptor CXCR3 mediates bonecancer pain throughanAkt ERKcross talk pathway in rats. Exp Neurol. 2015 Jan; 263: 39–49. doi: 10.1016/j.expneurol.2014.09.019.
18. Doong S.H., Dhruva A., Dunn L.B., West C., Paul S.M., Cooper B.A., Elboim C., Abrams G., Merriman J.D., Langford D.J., Leutwyler H., Baggott C., Kober K., Aouizerat B.E., Miaskowski C. Associations between cytokine genes and a symptom cluster of pain, fatigue, sleep disturbance, and depression in patients prior to breast cancer surgery. Biol Res Nurs. 2015; 17 (3): 23747. doi: 10.1177/1099800414550394.
19. Reyes-Gibby C.C., Shete S., Yennurajalingam S., Frazier M., Bruera E., Kurzrock R., Crane C.H., Abbruzzese J., Evans D., Spitz M.R. Genetic and nongenetic covariates of pain severity in patients with adenocarcinoma of the pancreas: assessing the influence of cytokine genes. J Pain Symptom Manage. 2009; 38 (6): 894–902.doi: 10.1016/j. jpainsymman.2009.04.019.
20. Luo M., Yang Y., Luo D., Liu L., Zhang Y., Xiao F., Yang J., Zhang C., FuS., Luo Z. Tumor necrosis factor-alpha promoter polymorphism 308 G/A is not significantly associated with esophageal cancer risk: a meta-analysis. Oncotarget. 2016; 7 (48): 79901–13. doi: 10.18632/oncotarget.13093.
21. Bandil K., Singhal P., Sharma U., Hussain S., Basu S., Parashari A., Singh V., Sehgal A., Shivam A., Ahuja P., Bharadwaj M., Banerjee B.D., Mehrotra R. Impacts of TNF-LTA SNPs/Haplotypes and Lifestyle Factors on Oral Carcinoma in an Indian Population. Mol Diagn Ther. 2016; 20 (5): 469–80. doi: 10.1007/s40291-016-0215-2.
22. Zhao H., Zhang H.W., Zhang T., Gu X.M. Tumor necrosis factor alpha gene -308G>A polymorphism association with the risk of esophageal cancer in a Han Chinese population. Genet Mol Res. 2016 Oct 7; 15 (4). doi: 10.4238/gmr.150458661.
23. Reyes-Gibby C.C., Spitz M.R., Yennurajalingam S., Swartz M., Gu J., Wu X., Bruera E., Shete S. Role of inflammation gene polymorphisms on pain severity in lung cancer patients. Cancer Epidemiol Biomarkers Prev. 2009; 18 (10): 2636–2642. doi: 10.1158/1055-9965.EPI-09-0426.
24. Sun Q., Guo X., Wang Q., Zhao F. The association of TNF-308 (G/A) gene polymorphisms and hepatocellular carcinoma risk: a metaanalysis. Chin J Cancer Res. 2016; 28 (5): 536–542. doi: 10.21147/j. issn.1000-9604.2016.05.09.
25. Rausch S.M., Gonzalez B.D., Clark M.M., Patten C., Felten S., Liu H., Li Y., Sloan J., Yang P. SNPs in PTGS2 and LTA predict pain and quality of life in long term lung cancer survivors. Lung Cancer. 2012; 77 (1): 217–23. doi: 10.1016/j.lungcan.2012.02.017.
26. Wang Z., Liu Y., Yang L., Yin S., Zang R., Yang G. The polymorphism interleukin-8 -251A/T is associated with a significantly increased risk of cancers from a meta-analysis. Tumour Biol. 2014; 35 (7): 7115–23. doi: 10.1007/s13277-014-1881-5.
27. Baune B.T., Dannlowski U., Domschke K., Janssen D.G., Jordan M.A., Ohrmann P., Bauer J., Biros E., Arolt V., Kugel H., Baxter A.G., Suslow T. The interleukin 1 beta (IL1B) gene is associated with failure to achieve remission and impaired emotion processing in major depression. Biol Psychiatry. 2010; 67 (6): 543–9. doi: 10.1016/j. biopsych.2009.11.004
28. Reyes-Gibby C.C., Spitz M., Wu X., Merriman K., Etzel C., Bruera E., Kurzrock R., Shete S. Cytokine genes and pain severity in lung cancer: exploring the influence of TNF-alpha-308 G/A IL6-174G/C and IL8-251- T/A. Cancer Epidemiol Biomarkers Prev. 2007; 16 (12): 2745–2751. doi: 10.1158/1055-9965.epi-07-0651.
29. Reyes Gibby C.C., Spitz M.R., Yennurajalingam S., Swartz M., Gu J., Wu X., Bruera E., Shete S. Role of inflammation gene polymorphisms on pain severity in lung cancer patients. Cancer Epidemiol Biomarkers Prev. 2009; 18 (10): 2636–42. doi: 10.1158/1055-9965.EPI-09-0426.
30. Müerköster S., Wegehenkel K., Arlt A., Witt M., Sipos B., Kruse M.L., Sebens T., Klöppel G., Kalthoff H., Fölsch U.R., Schäfer H. Tumor stroma interactions induce chemoresistance in pancreatic ductal carcinoma cells involving increased secretion and paracrine effects of nitric oxide and interleukin-1beta. Cancer Res. 2004; 64: 1331–1337.
31. Gan W.Y., Li H.M., Zhang Y.G., Li C.M., Wang Y. Association between IL18-607C/A and -137G/C polymorphisms and susceptibility to non-small cell lung cancer in a Chinese population. Genet Mol Res. 2016; 15 (4). doi: 10.4238/gmr15048822.
32. Zhao K., Xu J., Tian H. Correlation analysis between an IL-6 genetic polymorphism and non-small cell lung cancer prognosis. Genet Mol Res. 2016; 15 (1): 15017021. doi: 10.4238/gmr.15017021.
33. Quesada B.J.R., Talpaz M., Rios A., Kurzrock R., Gutterman J.U. Clinical toxicity of interferons in cancer patients: a review. J Clin Oncol. 2015; 4 (20): 234–243. doi:10.1200/JCO.1986.4.2.234
34. Von Ah.D.M., Kang D.H., Carpenter J.S. Predictors of cancerrelated fatigue in women with breast cancer before, during, and after adjuvant therapy. Cancer Nurs. 2008; 31 (2): 134–44. doi: 10.1097/01. NCC.0000305704.84164.54.
35. Xu J., Yin Z., Cao S., Gao W., Liu L., Yin Y., Liu P., Shu Y. Systematic review and meta-analysis on the association between IL-1B polymorphisms and cancer risk. PLoS One. 2013; 8 (5): e63654. doi: 10.1371/journal. pone.0063654.
36. Bastami S., Norling C., Trinks C., Holmlund B., Walz T.M., Ahlner J., Uppugunduri S. Inhibitory effect of opiates on LPS mediated release of TNF and IL-8. Acta Oncol. 2013 Jun; 52 (5): 1022–33. doi: 10.3109/0284186X.2012.737932.
37. Dahl A.A., Nesvold I.L., Reinertsen K.V., Fossa S.D. Arm/shoulder problems and insomnia symptoms in breast cancer survivors: crosssectional, controlled and longitudinal observations. Sleep Med. 2011 Jun; 12 (6): 584–90. doi: 10.1016/j.sleep.2011.01.011.
38. McCann B., Miaskowski C., Koetters T., Baggott C., West C., Levine J.D., Elboim C., Abrams G., Hamolsky D., Dunn L., Rugo H., Dodd M., Paul S.M., Neuhaus J., Cooper B., Schmidt B., Langford D., Cataldo J., Aouizerat B.E. Associations between pro- and anti-inflammatory cytokine genes and breast pain in women prior to breast cancer surgery. J Pain. 2012; 13 (5): 425–37. doi: 10.1016/j.jpain.2011.02.358.
39. Barratt D.T., Klepstad P., Dale O., Kaasa S., Somogyi A.A. Innate Immune Signalling Genetics of Pain, Cognitive Dysfunction andSickness Symptoms in Cancer Pain Patients Treated with Transdermal Fentanyl. PLoS One. 2015 Sep 2; 10 (9): e0137179. doi: 10.1371/journal. pone.0137179.
40. Sakamoto K., Takeda S., Kanekiyo S., Nishiyama M., Kitahara M., Ueno T., Yamamoto S., Yoshino S., Hazama S., Okayama N., Nagano H. Association of tumor necrosis factor-α polymorphism with chemotherapyinduced oral mucositis in patients with esophageal cancer. Mol Clin Oncol. 2017 Jan; 6 (1): 125–129. doi: 10.3892/mco.2016.1081.
41. Liu X., Wang Z., Yu J., Lei G., Wang S. Three polymorphisms in interleukin-1beta gene and risk for breast cancer: a meta-analysis. Breast Cancer Res Treat. 2010 Dec; 124 (3): 821–5. doi: 10.1007/s10549-010- 0910-3.
42. Ransohoff R.M. Chemokines and chemokine receptors: standing at the crossroads of immunobiology and neurobiology. Immunity. 2009 Nov 20; 31 (5): 711–21. doi: 10.1016/j.immuni.2009.09.010.
43. Nedoszytko B., Olszewska B., Roszkiewicz J., Glen J., Zabłotna M., Ługowska-Umer H., Nowicki R., Sokołowska-Wojdyło M. The role of polymorphism of interleukin-2, -10, -13 and TNF-α genes in cutaneous T-cell lymphoma pathogenesis. Postepy Dermatol Alergol. 2016 Dec; 33 (6): 429–434. doi: 10.5114/ada.2016.63881.
44. Li Y., Ou C., Shu H., Zhao H., Zhu B. The ERCC1-4533/8092, TNF-α 238/308 polymorphisms and the risk of hepatocellular carcinoma in Guangxi Zhuang populations of China: Case-control study. Medicine (Baltimore). 2016; 95 (44): e5217. doi: 10.1097/md.0000000000005217.
45. Gutiérrez-Hurtado I.A., Puebla-Pérez A.M., Delgado-Saucedo J.I., Figuera L.E., Zúñiga-González G.M., Gomez-Mariscal K., RonquilloCarreón C.A., Gallegos-Arreola M.P. Association between TNF-α-308G>A and -238G>A gene polymorphisms and TNF-α serum levels in Mexican colorectal cancer patients. Genet Mol Res. 2016; 15 (2). doi: 10.4238/ gmr.15028199.
46. Luo Y., Ye Z., Li K., Chen R., Li S., Pang J. Associations between polymorphisms in the IL-4 and IL-4 receptor genes and urinary carcinomas: a meta-analysis. Int J Clin Exp Med. 2015; 8 (1): 1227–1233.
47. Burada F., Dumitrescu T., Nicoli R., Ciurea M.E., Angelescu C., Mixich F., Ioana M. IL-1RN +2018T>C polymorphismis correlated with colorectal cancer. Mol Biol Rep. 2013; 40 (4): 2851–7. doi: 10.1007/ s11033-012-2300-x.
48. Sáenz López P., Vázquez Alonso F., Romero J.M., Carretero R., Tallada Buñuel M., Ruiz Cabello F., Cózar Olmo J.M. Polymorphisms in inflammatory response genes in metastatic renal cancer. Actas Urol Esp. 2009; 33 (5): 474–81.
49. Bapat A.A., Hostetter G., VonHoff D.D., Han H. Perineural invasion and associated pain in pancreatic cancer. Nat Rev Cancer. 2011; 11 (10): 695–707.doi: 10.1038/nrc3131.
50. Reyes-Gibby C.C., Wang J., Spitz M., Wu X., Yennurajalingam S., Shete S. Genetic variations in Interleukin-8 and Interleukin-10 are associated with pain, depressed mood, and fatigue in lung cancer patients. J Pain Symptom Manage. 2013; 46 (2): 161–72. doi: 10.1016/j. jpainsymman.2012.07.019.
51. Ando K., Takahashi F., Motojima S., Nakashima K., Kaneko N., Hoshi K., Takahashi K. Possible role for tocilizumab, an anti-interleukin-6 receptor antibody, in treating cancer cachexia. J Clin Oncol. 2013; 31 (60): e69–e72. doi: 10.1200/JCO.2012.44.2020.
Review
For citations:
Bobrova O.P., Shnayder N.A., Petrova M.M., Zyryanov K.S., Sychev D.A. CYTOKINE GENE POLYMORPHISMS AS PREDICTORS OF CHRONIC PAIN SYNDROME IN ONCOLOGY. Siberian journal of oncology. 2017;16(5):87-94. (In Russ.) https://doi.org/10.21294/1814-4861-2017-16-5-87-94
Views:
1068
Email this article 
