PROGNOSTIC FACTORS IN THE TREATMENT OF LUNG METASTASES FROM COLORECTAL CANCER
https://doi.org/10.21294/1814-4861-2018-17-2-60-70
Abstract
Based on the results of worldwide clinical studies, survival of colorectal cancer patients with lung metastases is significantly influenced by curative resection, number of metastases and disease free interval. Intrathoracic lymph node metastases in combination with pulmonary metastases as well as the CEA level of greater than 10ng/ml are found to be the most unfavorable prognostic factors. Most studies have found no significant relationship between survival and the size of the primary tumor and unilateral/bilateral distribution of pulmonary metastases. However, some authors consider that bilateral metastasis and T3-4 tumors are unfavorable prognostic factors. The key factors for surgical treatment of pulmonary metastases are the feasibility of performing curative resection and the absence of other manifestations of the disease.
About the Authors
B. B. Akhmedov
N.N. Blokhin National Medical Research Center of Oncology, Moscow
Russian Federation
MD, PhD, Senior Researcher, Department of Thoracic and Abdominal Surgery, N.N. Blokhin National Medical Research Center of Oncology (Moscow, Russia)
Russian Federation
MD, PhD, Senior Researcher, Department of Thoracic and Abdominal Surgery, N.N. Blokhin National Medical Research Center of Oncology (Moscow, Russia)
M. M. Davydov
N.N. Blokhin National Medical Research Center of Oncology, Moscow
Russian Federation
MD, DSc, Corresponding Member of the Russian Academy of Sciences, Head of the Department of Thoracic and Abdominal Surgery, N.N. Blokhin National Medical Research Center of Oncology (Moscow, Russia)
Russian Federation
MD, DSc, Corresponding Member of the Russian Academy of Sciences, Head of the Department of Thoracic and Abdominal Surgery, N.N. Blokhin National Medical Research Center of Oncology (Moscow, Russia)
M. Yu. Fedyanin
N.N. Blokhin National Medical Research Center of Oncology, Moscow
Russian Federation
MD, DSc, Senior Researcher, Department of Clinical Pharmacology and Chemotherapy, N.N. Blokhin National Medical Research Center of Oncology (Moscow, Russia)
Russian Federation
MD, DSc, Senior Researcher, Department of Clinical Pharmacology and Chemotherapy, N.N. Blokhin National Medical Research Center of Oncology (Moscow, Russia)
V. A. Aliev
N.N. Blokhin National Medical Research Center of Oncology, Moscow
Russian Federation
MD, DSc, Senior Researcher, Department of Coloproctology and Chemotherapy, N.N. Blokhin National Medical Research Center of Oncology (Moscow, Russia)
Russian Federation
MD, DSc, Senior Researcher, Department of Coloproctology and Chemotherapy, N.N. Blokhin National Medical Research Center of Oncology (Moscow, Russia)
S. S. Gordeev
N.N. Blokhin National Medical Research Center of Oncology, Moscow
Russian Federation
MD, PhD, Department of Coloproctology and Chemotherapy, N.N. Blokhin National Medical Research Center of Oncology (Moscow, Russia)
Russian Federation
MD, PhD, Department of Coloproctology and Chemotherapy, N.N. Blokhin National Medical Research Center of Oncology (Moscow, Russia)
I. A. Dadyev
N.N. Blokhin National Medical Research Center of Oncology, Moscow;
A.E. Evdokimov Moscow State University of Medicine and Dentistry, Moscow
Russian Federation
Postgraduate, A.E. Evdokimov Moscow State University of Medicine and Dentistry (Moscow, Russia)
Russian Federation
Postgraduate, A.E. Evdokimov Moscow State University of Medicine and Dentistry (Moscow, Russia)
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Review
For citations:
Akhmedov B.B., Davydov M.M., Fedyanin M.Yu., Aliev V.A., Gordeev S.S., Dadyev I.A. PROGNOSTIC FACTORS IN THE TREATMENT OF LUNG METASTASES FROM COLORECTAL CANCER. Siberian journal of oncology. 2018;17(2):60-70. (In Russ.) https://doi.org/10.21294/1814-4861-2018-17-2-60-70
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