THERMORADIOTHERAPY IN COMBINED MODALITY TREATMENT FOR RECTAL CANCER (LITERATURE REVIEW)
https://doi.org/10.21294/1814-4861-2018-17-2-89-94
Abstract
Preservation of the rectal sphincter during surgery for rectal cancer is necessary in order to maintain control of bowel function. For this purpose, novel approaches for combining sphincter-saving surgeries with neoadjuvant radiotherapy regimens are extensively developed. There are active discussions on the effectiveness of radiosensitization with the inclusion of chemical and physical components, one of which is local hyperthermia. This article reviews the worldwide experience in treating rectal cancer patients using local hyperthermia combined with radiation therapy. A wide variety of methods, as well as facilities for the procedure, is discussed. It should be noted that the selection of patients with rectal cancer for thermochemoradiotherapy and the choice of optimal irradiation volume remain a challenge.
About the Authors
D. A. Starodubtseva
Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk
Russian Federation
Russian Federation
MD, Physician, Radiology Department, Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences (Tomsk, Russia)
SPIN-код: 6461-3949
Zh. A. Startseva
Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk
Russian Federation
Russian Federation
MD, DSc, Professor of RAS, Head of Radiology Department, Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences (Tomsk, Russia)
SPIN-code: 8121-0310
S. G. Afanasyev
Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk
Russian Federation
Russian Federation
MD, DSc, Professor, Leading Researcher, Thoracic and Abdominal Department, Cancer Research Institute, Tom‑ sk National Research Medical Center of the Russian Academy of Medical Science (Tomsk, Russia)
SPIN-code: 9206-3037
A. Yu. Dobrodeev
Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk
Russian Federation
Russian Federation
MD, DSc, Senior Researcher, Thoracic and Abdominal Department, Tomsk Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Medical Science (Tomsk, Russia)
SPIN-code: 5510-4043
References
1. Ferlay J., Soerjomataram I., Ervik M., Dikshit R., Eser S., Mathers C., Rebelo M., Parkin D.M., Forman D., Bray F. GLOBOCAN 2012 v1.1, Can cer Incidence and Mortality Worldwide: IARC Cancer Base No. 11 [Inter net]. Lyon, France: International Agency for Research on Cancer; 2014.
2. Kaprin A.D., Starinsky V.V., Petrova G.V. Status of oncological care for the population of Russia in 2016. Moscow, 2017. 236. [in Russian]
3. Jemal A., Tiwari R.C., Murray T., Ghafoor A., Samuels A., Ward E., Feuer E.J., Thun M.J.; American Cancer Society. Cancer statistics, 2004. CA Cancer J Clin. 2004 Jan Feb; 54 (1): 8–29.
4. Cheng L., Eng C., Nieman L.Z. Kapadia A.S., Du X.L. Trends in colorectal cancer incidence by anatomic site and disease stage in the United State from 1976 to 2005. Am J Clin Oncol. 2011; 34: 573–580 doi: 10.1097/COC.0b013e3181fe41ed.
5. Chissov V.T., Frank G.A., Sidorov D.V., Maynovskaya O.A., Troitsky A.A., Lozhkin M.V., Grishin N.A., Petrov L.O. Results of surgical and combined treatment of colorectal cancer. Russian Oncological Journal. 2012; 3: 4–7. [in Russian]
6. Gunderson L.L., Sargent D.J., Tepper J.E., Wolmark N., O’Connell M.J., Begovic M., Allmer C., Colangelo L., Smalley S.R., Haller D.G., Martenson J.A., Mayer R.J., Rich T.A., Ajani J.A., MacDonald J.S., Willett C.G., Gold-berg R.M. Impact of T and N stage and treatment on survival and relapse in adjuvant rectal cancer: a pooled analysis // J Clin Oncol. 2004 May 15; 22 (10): 1785–96. doi: 10.1200/JCO.2004.08.173
7. Jalil O., Claydon L., Arulampalam T. Review of Neoadjuvant Chemotherapy Alone in Locally Advanced Rectal Cancer. J Gastrointest Cancer. 2015 Sep; 46 (3): 219–36. doi: 10.1007/s12029 015 9739 7.
8. Perez K., Safran H., Sikov W., Vrees M., Klipfel A., Shah N., Schechter S., Oldenburg N., Pricolo V., Rosati K., Dipetrillo T. Complete Neoadjuvant Treatment for Rectal Cancer: The Brown University Oncol ogy Group CONTRE Study. Am J Clin Oncol. 2017 Jun; 40 (3): 283–287. doi: 10.1097/COC.0000000000000149.
9. Shoji H., Motegi M., Osawa K., Okonogi N., Okazaki A., Andou Y., Asao T., Kuwano H., Takahashi T., Ogoshi K. Radiofrequency thermal treatment with chemoradiotherapy for advanced rectal cancer. Oncol Rep. 2016 May; 35 (5): 2569–2575. doi: 10.3892/or.2016.4659/
10. Huguier M., Houry S., Barrier A. Local recurrence of cancer of rectum. Am J Surgery. 2001; 182 (5): 437–9.
11. Afanasyev S.G., Startseva Zh.А., Tarasova А.S., Usova А.V., Samtsov Е.N. Results of combined modality treatment including preoperative plolonged chemotherary for rectal cancer. Siberian Journal of Oncology. 2012. 6: 5–12. [in Russian]
12. Meyer D.E., Kong G.A., Dewhirst M.W., Zalutsky M.R., Chilkoti A. Targeting a genetically engineered elastin – like polypeptide to solid tumors by local hyperthermia. Cancer Res. 2001; 61: 1548–54.
13. Palazzy M., Dall Oglio S. Is deep hyperthermia added to chemora diotherapy useful in the treatment of locally advanced anal cancer. Verona mono – institutional experience (2000–2006). Tumori. 2008; 7: 151.
14. Gani C., Schroeder C., Heinrich V., Spillner P., Lamprecht U., Berger B., Zips D. Long term local control and survival after preopera tive radiochemotherapy in combination with deep regional hyperthermia in locally advanced rectal cancer. Int J Hyperthermia. 2016. Vol. 32 (2). P. 187–192. doi: 10.3109/02656736.2015.1117661
15. De Haas-Kock D.F., Buijsen J., Pijls-Johannesma M., Lutgens L., Lammering G., van Mastrigt G.A., De Ruysscher D.K., Lambin P., van der Zee J. Concomitant hyperthermia and radiation therapy for treating locally advanced rectal cancer. Cochrane Database Syst Rev. 2009 Jul 8; (3): CD006269. doi: 10.1002/14651858.CD006269.pub2. Review.
16. Camma С., Giunta M., Fiorica F., Pagliaro L., Craxì A., Cottone M. Preoperative radiotherapy for resectable rectal cancer: a meta analysis. JAMA. 2000. Vol. 284. P. 1008–1015.
17. Song C.W., Park H., Griffin R.J. Improvement of tumor oxygen ation by mild hyperthermia. Radiat Res. 2001; 155: 515–28.
18. Clifford L.K. The Orientation, Application and Efficacy Evaluation of Hyperthermia in Integrative Natural Therapies of Cancer. Oncothermia J. 2014; 10: 15–27.
19. Moluta S., Romano M., Dall’oglio S., Genna M., Oliani C., Pioli F., Gabbani M., Marciai N., Palazzi M. Regional hyperthermia added to inten sified preoperative chemio radiation in locally advanced adenocarcynoma of midlle and lower rectum. In J Hyperthermia 2010; 26 (2): 108–17 doi: 10.3109/02656730903333958.
20. Shoji H., Motegi M., Osawa K., Okonogi N., Okazaki A., Andou Y., Asao T., Kuwano H., Takahashi T., Ogoshi K. A novel strategy of radiof requency hyperthermia (neothermia) in combination with preoperative chemoradiotherapy for the treatment of advanced rectal cancer: a pilot study. Cancer Med. 2015; 4 (6): 834–43. doi: 10.1002/cam4.431.
21. Shoji H., Motegi M., Takakusagi Y., Asao T., Kuwano H., Takahashi T., Ogoshi K. Chemoradiotherapy and concurrent radiofrequency thermal therapy to treat primary rectal cancer and prediction of treat ment responses. Oncol Rep. 2017 Feb; 37 (2): 695–704. doi: 10.3892/ or.2016.5300.
22. Schroeder C., Gani C., Lamprecht U., von Weyhern C.H., Weinmann M., Bamberg M., Berger B. Pathological complete response and sphincter sparing surgery after neoadjuvant radiochemotherapy with regional hyperthermia for locally advanced rectal cancer compared with radiochemotherapy alone. Int J Hyperthermia. 2012; 28 (8): 707–14. doi: 10.3109/02656736.2012.722263.
23. Schulze T., Wust P., Gellermann J., Hildebrandt B., Riess H., Felix R., Rau B. Influence of neoadjuvant radiochemotherapy combined with hyper thermia on the quality of life in rectum cancer patients. Int J Hyperthermia. 2006; 22 (4): 301–318 doi.org/10.1080/02656730600665504/
24. Barsukov Yu.A., Tkachev S.I., Tsaryuk V.F., Gordeev S.S., Perevoshikov A.G., Malikhov A.G., Oltarzhevskaya N.D., Aliev V.A., Kuzmichev D.V., Glebovskaya V.V., Osombaev M.Sh. Efficacy of neoadjuvant chemo radiotherapy of locally advanced rectal cancer in conjunction with local hyperthermia and metronidazole. Problems in Oncology. 2011; 57 (3): 373–377. [in Russian]
25. Tamrazov R.I., Barsukov Yu.A., Tkachev S.I., Nikolaev A.V., Gordeev S.S. Local hyperthermia in rectal cancer treatment: a view on future from the past. Oncological coloproctology. 2011; 3: 12–21 [in Russian].
26. Barsukov Yu.A., Kuzmichev D.V., Tkachev S.I., Aliev V.A., Tamra-zov R.I., Malikhov A.G., Mamedli Z.Z.., Tatatev I.Sh., Vlasov O.A., Gordeev S.S. Combination neoadjuvant thermochemical therapy in patients with rectal cancer. Oncological coloproctology. 2014; (3): 23–28. doi:10.17650/2220 3478 2014 0 3 23 28. [in Russian]
27. Rasulov A.O., Gordeev S.S., Ivanov V.A., Barsukov Yu.A., Ma-likhov A.G., Baichorov A.B., Tkachev S.I., Kozak E.N. Preoperative short course radiotherapy with chemotherapy, local hyperthermia and delayed surgery in treatment rectal cancer: phase II trial. Oncological coloproctology. 2016; 6 (4): 24–30. doi: 10.17650/2220 3478 2016 6 4 24 30. [in Russian]
Review
For citations:
Starodubtseva D.A., Startseva Zh.A., Afanasyev S.G., Dobrodeev A.Yu. THERMORADIOTHERAPY IN COMBINED MODALITY TREATMENT FOR RECTAL CANCER (LITERATURE REVIEW). Siberian journal of oncology. 2018;17(2):89-94. (In Russ.) https://doi.org/10.21294/1814-4861-2018-17-2-89-94
Views:
1030
Email this article 
