DYNAMICS OF OBSERVED AND RELATIVE SURVIVAL OF PATIENTS WITH PRIMARY LIVER CANCER ON THE POPULATION LEVEL ACCORDING TO DISEASE STAGE AND HISTOLOGICAL STRUCTURE

Introduction. Liver cancer relates to serious cancer pathology. The study of risk factors for liver cancer is the subject of many publications including experimental research. Of 16 countries, which presented data on estimation of relative oneand five-year survival of patients with liver cancer (both sexes) in the European countries (the program Eurocare-4), only in five countries a 5-year relative survival exceeded 10 %. The European average rate of a 5-year relative survival (for both sexes) was 8.7 %. For men it was equal to 8.9 % and for women 8.4 %. Purpose. To provide for the first time in Russia on the population level an analysis of dynamics of survival of liver cancer patients in accordance with database of the Population-Based Cancer Registry of St. Petersburg, the first in Russia working on international standards, in comparison with the programs Eurocare-3 and 4. Also it was necessary to estimate a number of analytical indicators, which reflect the state of problem. Material and methods. To solve this purpose there were studied the state of problem in European registries, data on state reporting of Russia and primary materials of the Population-Based Cancer Registry of St. Petersburg. The total number of observations according to the Population-Based Cancer Registry of St. Petersburg was 4003 cases of primary liver cancer including 2218 cases among men and 1785 among women. For the estimation of observed and relative survival rates there were used estimations of rates, modified by us, of the programs Eurocar-3 and 4. Results. There has been established the level, close to the European average, of observed and relative 5-year survival of liver cancer patients, both men and women of St. Petersburg. Throughout the whole period of observation it was revealed an extremely low level in median survival. Coding of histological forms of malignant tumors of the liver was significantly improved. The proportion of ICD codes 8000/3 and 8010/3 decreased among men from 71.6 % to 8.2 %, among women with 48.48 % to 6.38 %. Conclusion. Malignant tumors of the liver are severe pathology in oncology. It is required not only an improvement of the primary estimation but also more accurate coding and providing timely medical care to patients.

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