COMBINED MODALITY TREATMENT FOR PATIENTS WITH INOPERABLE COLORECRAL LIVER METASTASES
https://doi.org/10.21294/1814-4861-2018-17-3-34-40
Abstract
The purpose of the study was to improve treatment outcomes for patients with inoperable colorectal liver metastases using the combination of chemoembilization of the hepatic artery and radiofrequency ablation.
Material and methods. Treatment outcomes of 60 patients with methachronic unresectable liver metastases from colorectal cancer were analyzed. Eligibility criteria were as follows: absence of extrahepatic metastases, size of metastases from 3 to 5 cm, and inability to perform resection. All patients were divided into two groups. Group I included 30 patients who received combination of regional chemotherapy and radiofrequency ablation. Group II (the control group) consisted of 30 patients who received radiofrequency ablation only.
Results. Post-embolization and post-ablation syndromes were observed in both groups of patients. Rightsided hydrothorax (Clavien-Dindo grade II) was found in 4 out of 60 patients (2 patients in Group I and 2 patients in Group II). One-, two- and three-year disease-free survival rates in Group I patients were 96.6 %, 76.6 % and 53.3 %, respectively. The corresponding rates in the control group patients were 90.0 %, 53.6 % and 30.0 %, respectively (p=0.049). The overall one-, two-and three-year survival rates in Group I patients were 100 %, 90 % and 63.3 %, respectively. The corresponding rates in the control group patients were 100 %, 70 % and 50.0 %, respectively (p=0.202).
Conclusion. The combination of regional chemotherapy and radiofrequency ablation led to the improvement in overall and disease-free survival rates.
About the Authors
A. V. Shabunin
Russian Medical Academy of Postgraduate Education
S.P. Botkin City Clinical Hospital
Russian Federation
Russian Federation
2/1, Barrikadnaya Street, 125993-Moscow, Russia
5, 2-nd Botkinsky proezd, 125284-Moscow, Russia
MD, Professor, Corresponding Member of the Russian Academy of Sciences, Head of Surgery Department, Russian Medical Academy of Postgraduate Education; Chief Physician of S.P. Botkin City Clinical Hospital (Moscow, Russia). ResearcherID: W-1068-2017
M. M. Tavobilov
Russian Medical Academy of Postgraduate Education
S.P. Botkin City Clinical Hospital
Russian Federation
Russian Federation
2/1, Barrikadnaya Street, 125993-Moscow, Russia
5, 2-nd Botkinsky proezd, 125284-Moscow, Russia
MD, PhD, Surgery Department, Russian Medical Academy of Postgraduate Education; Head of the Department of Liver and Pancreas Surgery, S.P. Botkin City Clinical Hospital (Moscow, Russia)
D. N. Grekov
Russian Medical Academy of Postgraduate Education
S.P. Botkin City Clinical Hospital
Russian Federation
Russian Federation
2/1, Barrikadnaya Street, 125993-Moscow, Russia
5, 2-nd Botkinsky proezd, 125284-Moscow, Russia
MD, PhD, Surgery Department, Russian Medical Academy of Postgraduate Education, Head of the Abdominal Surgery Department, S.P. Botkin City Clinical Hospital (Moscow, Russia)
P. A. Drozdov
S.P. Botkin City Clinical Hospital
Russian Federation
Russian Federation
5, 2-nd Botkinsky proezd, 125284-Moscow, Russia
MD, Physician, Department of Liver and Pancreas Surgery, S.P. Botkin City Clinical Hospital (Moscow, Russia)
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For citations:
Shabunin A.V., Tavobilov M.M., Grekov D.N., Drozdov P.A. COMBINED MODALITY TREATMENT FOR PATIENTS WITH INOPERABLE COLORECRAL LIVER METASTASES. Siberian journal of oncology. 2018;17(3):34-40. (In Russ.) https://doi.org/10.21294/1814-4861-2018-17-3-34-40
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