THE ROLE OF COMPUTED TOMOGRAPHY IN PATIENTS WITH GASTRIC CANCER IN RADIO-ONCOLOGICAL HOSPITAL
Abstract
Background. Patients are referred to a specialized oncologic hospital with diagnosis of gastric cancer, which has been already established. Under this condition it is important to determine the clinical problems in which CT plays a crucial role. The aim of the study is the systematization of the major clinical challenges being addressed by CT in patients with gastric cancer treated at the radio-oncological hospital. Methods. A total 120 patients with gastric cancer at the different phases of combination therapy were included in our study: 91 patients underwent preoperative CT for the tumor staging; 70 patients underwent CT topometry; 40 patients were examined with CT in order to the post-therapy control. Results. The role of computed tomography in the study of gastric carcinoma is mainly represented by the staging of tumor according to the TNM system; CT topometry; assessment of response to neoadjuvant therapy; evaluation of postoperative complications and the post-therapy control. Conclusion. In a specialized hospital, CT plays a key role in the management of gastric cancer. CT has important impacts on clinical decisions and allows solving specific clinical problems.
About the Authors
N. K. Silanteva
Tsyb Medical Radiological Research Centre – branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, Obninsk
Russian Federation
Russian Federation
Silanteva Natalia Konstantinovna, MD, DSc, Head of the Department of Computed Tomography.
Phone: +7 (484) 399-30-67. E-mail: nks07@mail.ru. SPIN-code: 3312-4117
T. A. Agababian
Tsyb Medical Radiological Research Centre – branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, Obninsk
Russian Federation
Russian Federation
Agababian Tatev Artakovna, MD, PhD, Senior Research Associate of the Department of Computed Tomography.
Phone: +7 (484) 399-33-03. E-mail: tatevik.05@mail.ru. SPIN-code: 5752-3393
V. Yu. Skoropad
Tsyb Medical Radiological Research Centre – branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, Obninsk
Russian Federation
Russian Federation
Skoropad Vitaliy Yurievich, MD, DSc, Leading Research Associate of the Department of Abdominal Oncology.
Phone: +7 (484) 399-31-65. E-mail: skoropad@mrrc.obninsk.ru. SPIN-code: 2283-1111
O. G. Grishina
Tsyb Medical Radiological Research Centre – branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, Obninsk
Russian Federation
Russian Federation
Grishina Olga Gennadievna, MD, Research Associate of the Department of Computed Tomography.
Phone: +7 (484) 399-33-03. E-mail: life0813@mail.ru. SPIN-code: 3062-650
References
1. Agababian T.A., Silanteva N.K., Skoropad V.Yu. Evaluation of local spread of gastric cancer with multidetector computed tomography // Meditsinskaya vizualizatsiya. 2011. № 6. P. 21–29. [in Russian]
2. Algorithms for diagnosis and treatment of malignant neoplasms / ed. by V.I. Chissov. М., 2010. 543 p. [in Russian]
3. Arablinskij V.M., Sedyh S.A., Mamontov A.S. Computed tomography in the diagnosis of regional metastases in esophageal and proximal gastric cancer patients // Sovetskaja Medicina. 1991. № 9. P. 26–29. [in Russian]
4. Gorshkov A.N., Meshkov V.M., Gracheva N.I., Zaritskaya V.A. Potentialities of radiation techniques (ultrasonography, computed tomography) in the preoperative evaluation of intramural invasion of gastric carcinoma // Vestnik rentgenologii i radiologii. 2001. № 2. P. 27–34. [in Russian]
5. Malignancies in Russia in 2013 (morbidity and mortality) / Ed. by A.D. Kaprin, V.V. Starinskij, G.V. Petrova. М., 2015. 250 p. [in Russian]
6. Parts S.А., Tuzikov S.А., Leskov S.V., Kuzmina E.S., Afanasyev S.G., Volkov М.Yu. Short-and long-term results of combined modality treatment with the use of preoperative radiation therapy for cardiac gastric cancer // Sibirskij onkologicheskij zhurnal. 2011. № 2. P. 67–71. [in Russian]
7. Ahn H.S., Lee H.J., Yoo M.W., Kim S.G., Im J.P., Kim S.H., Kim W.H., Lee K.U., Yang H.K. Diagnostic accuracy of T and N stages with endoscopy, stomach protocol CT, and endoscopic ultrasonography in early gastric cancer // J. Surg. Oncol. 2009. Vol. 99 (1). P. 20–27. doi: 10.1002/jso.21170.
8. Anzidei M., Napoli A., Zaccagna F., Di Paolo P., Zini C., Cavallo Marincola B., Geiger D., Catalano C., Passariello R. Diagnostic performance of 64-MDCT and 1.5-T MRI with high-resolution sequences in the T staging of gastric cancer: a comparative analysis with histopathology // Radiol. Med. 2009. Vol. 114 (7). P. 1065–1079. doi: 10.1007/s11547-009-0455-x.
9. Chen C.Y., Hsu J.S., Wu D.C., Kang W.Y., Hsieh J.S., Jaw T.S., Wu M.T., Liu G.C. Gastric cancer: preoperative local staging with 3D multi-detector row CT-correlation with surgical and histopathologic results // Radiology. 2007. Vol. 242 (2). P. 472–482.
10. Choi H. Response evaluation of gastrointestinal stromal tumors // Oncologist. 2008. Vol. 13. Suppl. 2. P. 4–7. doi: 10.1634/theoncologist.13S2-4.
11. Cidón E.U., Cuenca I.J. Gastric adenocarcinoma: is computed tomography useful in preoperative staging? // Clinical Medicine: Oncology. 2009. Vol. 3. P. 91–97.
12. De Angelis R., Sant M., Coleman M.P., Francisci S., Baili P., Pierannunzio D., Trama A., Visser O., Brenner H., Ardanaz E., Bielska-Lasota M., Engholm G., Nennecke A., Siesling S., Berrino F., Capocaccia R; EUROCARE-5 Working Group. Cancer survival in Europe 1999–2007 by country and age: results of EUROCARE--5-a population-based study // Lancet Oncol. 2014. Vol. 15 (1). P. 23–34. doi: 10.1016/S1470-2045(13)70546-1.
13. Eisenhauer E.A., Therasse P., Bogaerts J., Schwartz L.H., Sargent D., Ford R., Dancey J., Arbuck S., Gwyther S., Mooney M., Rubinstein L., Shankar L., Dodd L., Kaplan R., Lacombe D., Verweij J. New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1) // Eur. J. Cancer. 2009. Vol. 45 (2). P. 228–247. doi: 10.1016/j.ejca.2008.10.026.
14. Horton K.M., Fishman E.K. Current role of CT in imaging of the stomach // Radiographics. 2003. Vol. 23 (1). P. 75–87.
15. Japan esophageal society. Japanese classification of esophageal cancer, tenth edition: parts II and III // Esophagus. 2009. Vol. 6. P. 71–94.
16. Japanese gastric cancer association. Japanese classification of gastric carcinoma: 3rd English edition // Gastric Cancer. 2011. Vol. 14. P. 101–112. doi: 10.1007/s10120-011-0041-5.
17. Kim H.J., Kim A.Y., Oh S.T., Kim J.S., Kim K.W., Kim P.N., Lee M.G., Ha H.K. Gastric cancer staging at multi-detector row CT gastrography: comparison of transverse and volumetric CT scanning // Radiology. 2005. Vol. 236 (3). P. 879–885.
18. Kim H.S., Han H.Y., Choi J.A., Park C.M., Cha I.H., Chung K.B., Mok Y.J. Preoperative evaluation of gastric cancer: value of spiral CT during gastric arteriography (CTGA) // Abdom. Imaging. 2001. Vol. 26 (2). P. 123–130.
19. Kim K.W., Choi B.I., Han J.K., Kim T.K., Kim A.Y., Lee H.J, Kim Y.H., Choi J.I., Do K.H., Kim H.C., Lee M.W. Postoperative anatomic and pathologic findings at CT following gastrectomy // Radiographics. 2002. Vol. 22 (2). P. 323–336.
20. Kunz P.L., Gubens M., Fisher G.A., Ford J.M., Lichtensztajn D.Y., Clarke C.A. Long-term survivors of gastric cancer: a California populationbased study // J. Clin. Oncol. 2012. Vol. 30 (28). P. 3507–3515.
21. Lee J.H., Jeong Y.K., Kim D.H., Go B.K., Woo Y.J., Ham S.Y., Yang S.O. Two-phase helical CT for detection of early gastric carcinoma: importance of the mucosal phase for analysis of the abnormal mucosal layer // J. Comput. Assist. Tomogr. 2000. Vol. 24 (5). P. 777–782.
22. Makino T., Fujiwara Y., Takiguchi S., Tsuboyama T., Kim T., Nushijima Y., Yamasaki M., Miyata H., Nakajima K., Mori M., Doki Y. Preoperative T staging of gastric cancer by multi-detector row computed tomography // Surgery. 2011. Vol. 149 (5). P. 672–679. doi: 10.1016/j.surg.2010.12.003.
23. Ogata I., Komohara Y., Yamashita Y., Mitsuzaki K., Takahashi M., Ogawa M. CT evaluation of gastric lesions with three-dimensional display and interactive virtual endoscopy: comparison with conventional barium study and endoscopy // AJR. 1999. Vol. 172 (5). P. 1263–1270.
24. Polkowski M., Palucki J., Wronska E., Szawlowski A., NasierowskaGuttmejer A., Butruk E. Endosonography versus helical computed tomography for locoregional staging of gastric cancer // Endoscopy. 2004. Vol. 36 (7). P. 617–623.
25. Vallböhmer D., Hölscher A.H., Schneider P.M., Schmidt M., Dietlein M., Bollschweiler E., Baldus S., Alakus H., Brabender J., Metzger R., Mönig S.P. [18F]-fluorodeoxyglucose-positron emission tomography for the assessment of histopathologic response and prognosis after completion of neoadjuvant chemotherapy in gastric cancer // J. Surg. Oncol. 2010. Vol. 102 (2). P. 135–140. doi: 10.1002/jso.21592.
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For citations:
Silanteva N.K., Agababian T.A., Skoropad V.Yu., Grishina O.G. THE ROLE OF COMPUTED TOMOGRAPHY IN PATIENTS WITH GASTRIC CANCER IN RADIO-ONCOLOGICAL HOSPITAL. Siberian journal of oncology. 2015;1(5):5-13. (In Russ.)
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