CHITINASE-LIKE PROTEINS AS PROMISING MARKERS IN CANCER PATIENTS
https://doi.org/10.21294/1814-4861-2018-17-4-99-105
Abstract
In the present review we collected the main studies regarding the role of chitinase-like proteins (CLPs), belonging to the family of Glyco_18 domain-containing proteins, in different cancers. In humans, 3 chitinaselike proteins have been identified: YKL-40 (CHI3L1), YKL-39 (CHI3L2) and stabilin-1-interacting chitinase-like protein (SI-CLP). CLPs are produced by several types of cells and combine the properties of cytokines and growth factors. The high levels of CLPs were identified in the circulation of the patients with inflammatory diseases and various types of tumors. We highlighted the main known functions of CLPs in normal and pathological conditions, their contribution to metastasis development, angiogenesis, invasion and other processes in cancer, the correlation of the levels of CLPs with tumour progression. Our data also contribute to the understanding of question how CLP could be useful for cancer patient benefit.
About the Authors
I. V. Larionova
Tomsk State University
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
Russian Federation
36, Lenina av., 634050-Tomsk, Russia
5, Kooperativny Street, Tomsk, Russia, 634050
Junior Researcher of Laboratory of Translational Cellular and Molecular Biomedicine, Tomsk State University; Postgraduate, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
Researcher ID (WOS): R-2391-2017. Author ID (Scopus): 57201182530
T. N. Sevastyanova
Tomsk State University
Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, University of Heidelberg
Russian Federation
Russian Federation
36, Lenina av., 634050-Tomsk, Russia
1-3, Theodor-Kutzer-Ufer, 68167-Mannheim, Germany
Junior Researcher of Laboratory of Translational Cellular and Molecular Biomedicine, Tomsk State University; Postgraduate, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
Researcher ID (WOS): R-2391-2017. Author ID (Scopus): 57201182530
A. A. Rakina
National Research Tomsk Polytechnic University
Russian Federation
Russian Federation
30, Lenina av., Tomsk, Russia, 634050
Engineer, National Research Tomsk Polytechnic University
Researcher ID (WOS): O-6297-2018.
N. V. Cherdyntseva
Tomsk State University
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
Russian Federation
36, Lenina av., 634050-Tomsk, Russia
5, Kooperativny Street, Tomsk, Russia, 634050
DSс, Professor, Corresponding member of Russian Academy of Sciences, the Head of the Laboratory of Molecular oncology and immunology, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences; senior researcher of Laboratory of translational cellular and molecular biomedicine, Tomsk State University
Researcher ID (WOS): С-7943-2012. Author ID (Scopus): 6603911744
Ju. G. Kzhyshkowska
Tomsk State University
Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, University of Heidelberg
German Red Cross Blood Service Baden-Württemberg-Hessen
Russian Federation
Russian Federation
36, Lenina av., 634050-Tomsk, Russia
1-3, Theodor-Kutzer-Ufer, 68167-Mannheim, Germany
107, Friedrich-Ebert Str., 68167-Mannheim, Germany
DSс, Professor, the Head of the Laboratory of translational cellular and molecular biomedicine, Tomsk State University; Head of Department of Innate Immunity and Tolerance, Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, University of Heidelberg
Researcher ID (WOS): J-5835-2016. Author ID (Scopus): 6603091281
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For citations:
Larionova I.V., Sevastyanova T.N., Rakina A.A., Cherdyntseva N.V., Kzhyshkowska J.G. CHITINASE-LIKE PROTEINS AS PROMISING MARKERS IN CANCER PATIENTS. Siberian journal of oncology. 2018;17(4):99-105. https://doi.org/10.21294/1814-4861-2018-17-4-99-105
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