Preview

Siberian journal of oncology

Advanced search

MULTICENTRIC EARLY GASTRIC CANCER: CURRENT APPROACHES TO SURGICAL TREATMENT

Abstract

Opinions regarding multicentric tumor growth as prognostic factor in early gastric cancer are contradictory. The question about the rational extent of surgery for multicentric early cancer is also controversial. Some authors recommend performing only gastrectomy, others consider that resection of the stomach is adequate in most cases and the third authors consider it is possible to perform endoscopic mucosectomy in some cases. The present study demonstrates treatment results of 394 patients with early gastric cancer who  underwent surgery from 1990 to 2008. Multicentric tumor growth was diagnosed in 23 of 394 (5.5 %) patients. All patients received surgical treatment. Multicentric early gastric cancer showed no increase in the rate of lymphogenic metastatsis and worsening of surgical treatment results in comparison with monocentric gastric cancer. Similar survival rates irrespective of the number of foci of early gastric carcinoma indicate no prognostic
significance of multicentric growth for early gastric cancer.

About the Authors

M. I. Davydov
N.N. Blokhin Russian Cancer Research Center RAMS, Moscow
Russian Federation


I. N. Turkin
N.N. Blokhin Russian Cancer Research Center RAMS, Moscow
Russian Federation


References

1. Долгов И.Ю. Ранний рак желудка (диагностика, лечение, прогноз): Автореф. дис. … канд. мед. наук. М., 1992. 25 с.

2. Черноусов А.Ф., Поликарпов С.А., Годжелло Э.А. Ранний рак и предопухолевые заболевания желудка. М.: ИздАт, 2002. 253 с.

3. Черноусов А.Ф., Черноусов Ф.А., Селиванова И.М. Радикальное хирургическое лечение раннего рака желудка // Хирургия. Журнал им. Н.И. Пирогова. 2004. № 7. С. 4–8.

4. Чернявский А.А., Шарандов Е.А. Ранний рак (in situ) желудка и его хирургическое лечение // Анналы хирургии. 2001. № 6. С. 59–64.

5. Borie F., Plaisant N., Millat B. et al. M.D. for the French Association for Surgical Research. Apropriate Gastric Resection with Lymph Node Dissection for Early gastric Cancer // Ann. Surg. Oncol. 2004. Vol. 11 (5). P. 512–517.

6. Borie F., Plaisant N., Millat B. et al. Treatment and prognosis of early multiple gastric cancer // Eur. J. Surg. Oncol. 2003. Vol. 29 (6). P. 511–514.

7. Bozzetti F., Marubini E., Bonfanti G. et al. Total Verlus Subtotal Gastrectomy: surgical morbidity and mortality rates in a Multicenter Italian Randomized Trial. The Italian Gastrointestinal Tumor Study Group // Ann. Surg. 1997. Vol. 5. P. 613–620.

8. Endo M., Habu H. Clinical studies of early gastric cancer // Hepatogastroenterology. 1990. Vol. 37. P. 408–410.

9. Isozaki H., Okajima K., Hu X. et al. Multiple early gastric carcinomas. Clinicopathologic feautures and histogenesis // Cancer. 1996. Vol. 78 (10). P. 2078–2086.

10. Kitamura K., Yamaguchi T., Okamoto K et al. Total gastrectomy for early gastric cancer // J. Surg. Oncol. 1995. Vol. 60 (2). P. 83–88.

11. Kosaka T., Miwa K., Yonemura Y. et al. A clinicopathologic study on multiple gastric cancers with special reference to distal gastrectomy // Cancer. 1990. Vol. 65. P. 2602–2605.

12. Lawrence M., Shiu M.H. Early gastric cancer. Twenty-eight year experience // Ann. Surg. 1991. Vol. 213. P. 327–334.

13. Moertel C.G., Bargen J.A., Soule E.H. Multiple gastric cancers: review of the literature and study of 42 cases // Gastroenterology. 1957. Vol. 32. P. 1095.

14. Ohta H., Noguchi Y., Takagi K. et al. Early gastric carcinoma with special reference to Macroscopic classification // Cancer. 1987. Vol. 60. P. 1099–1106.

15. Oliveira F.J., Ferrao H., Furtado E. et al. Early gastric cancer: Report of 58 cases // Gastric Cancer. 1998. Vol. 1. P. 51–56.

16. Piso P., Werner U., Benten D. et al. Early gastric cancer-excellent prognosis after curative resection in 87 patients irrespective of submucosal infiltration, lymph node metastases or tumor size // Langenbeck’s Arch. Surg. 2001. Vol. 386. P. 26–30.

17. Seto Y., Nagawa H., Muto T. Treatment of Multiple Early Gastric Cancer // Jpn. J. Clin. Oncol. 1996. Vol. 26. P. 134–138.

18. Takeshita K., Tani M., Honda T. et al. Treatment of Primary Multiple Early Gastric Cancer: From the Viewpoint of Clinicopathologic Features // World J. Surg. 1997. Vol. 21. P. 832–836.

19. UICC. TNM Classification of malignant tumors / Eds. L.Y. Sobin, Ch. Wittekind. 6th ed. New-York: Wiley-Liss, 2002.


Review

For citations:


Davydov M.I., Turkin I.N. MULTICENTRIC EARLY GASTRIC CANCER: CURRENT APPROACHES TO SURGICAL TREATMENT. Siberian journal of oncology. 2013;(2):5-11. (In Russ.)

Views: 803


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1814-4861 (Print)
ISSN 2312-3168 (Online)