Preview

Siberian journal of oncology

Advanced search

WHAT DEFINES THE EXTENT OF LYMPHODISSECTION FOR EARLY GASTRIC CANCER?

Abstract

Surgery strategy for patients with early gastric cancer remains disputable. The main reason of controversy is the extent of surgical intervention, namely, whether D2 dissection  improves treatment outcomes of early gastric cancer? The present study demonstrates treatment outcomes of 394 patients who underwent surgery for early gastric cancer between 1990–2008. The major risk factors for lymphogenic metastasis (lymphatic invasion, cancer invasion into submucous layer, tumor size > 4.0 cm venous invasion, tumor spread to the esophagus, macroscopic types 0I and 0III and poorly-differentiated tumor) have been found to be an absolute indication for D2 lymphodissection. The restriction of surgery extent to D1-lymphodissection is possible only in patients with negligibly low risk of metastasis regardless of the type of early cancer.

About the Authors

I. N. Turkin
N.N. Blokhin Russian Cancer Research Center RAMS, Moscow
Russian Federation


M. I. Davydov
N.N. Blokhin Russian Cancer Research Center RAMS, Moscow
Russian Federation


References

1. Карачун А.М., Беляев А.М., Синенченко Г.И., Пелипась Ю.В. Объем лимфодиссекции при раке желудка: общепринятый стандарт или предмет для дискуссий (обзор литературы) // Сибирский онколонгический журнал. 2011. № 5 (47). С. 70–78.

2. Черноусов Ф.А., Селиванова И.М., Фишкова З.П. Радикальное хирургическое лечение раннего рака желудка // Хирургия. Журнал им. Н.И. Пирогова. 2007. № 7. С. 61–69.

3. Abe N., Watanabe T., Suzuki K. et al. Risc factors predictive of lymph node metastasis in depressed early gastric cancer // Am. J. Surg. 2002. Vol. 183. P. 168–172.

4. Degiuli M., Calvo F. Survival of early gastric cancer in a specialized European Center. Which Lymphadenectomy is necessary? // World J. Surg. 2006. Vol. 30. P. 2193–2203.

5. Gotoda T. Endoscopic resection of early gastric cancer: rewiew article // Gastric Cancer. 2007. Vol. 10. P. 1–11.

6. Hu X., Cao L., Tian D.Y. et al. Clinical study of lymph node dissection for early gastric cancer // Zhonghua Wai Ke Za Zhi. 2009. Vol. 47 (17). P. 1302–1304.

7. Kunisaki C., Shimada H., Nomura M. et al. Appropriate lymph node dissection for early gastric cancer based on lymph node metastases // Surgery. 2000. Vol. 129. P. 153–157.

8. Li H., Lu P., Lu Y. et al. Predictive factor of lymph node metastasis in undifferentiated early gastric cancers and application of endoscopic mucosal resection // Surg. Oncol. 2010. Vol. 19 (4). P. 221–226.

9. Ludwig K., Klautke G., Bernnard J., Weiner R. Minimally invasive and local treatment for mucosal early gastric cancer // Surg. Endosc. 2005. Vol. 19. P. 1362–1366.

10. Miwa K. Optimal nodal dissection for early gastric cancer // Nippon. Geka. Gakkai Zasshi. 2001. Vol. 102 (6). P. 484–489.

11. Morgagni P., Garcea D., Marreli D. et al. Does resection line involvement affect prognosis in early gastric cancer patients? An Italian Multicentric Study // World J. Surg. 2006. Vol. 30. P. 585–589.

12. Nitti D., Marchet A., Mammano E. et al. Extended lymphadenectomy (D2) in patients with early gastric cancer // EJSO. 2005. Vol. 31. P. 875–881.

13. Oda I., Saito D., Tada M. et al. A multicenter retrospective study of endoscopic resection for early gastric cancer // Gastric Cancer. 2006. Vol. 9. P. 262–270.

14. Onodera H., Tokunaga A., Yoshiyki T. et al. Surgical outcome of 483 patients with early gastric cancer: prognosis, postoperative morbidity and mortality and gastric remnant cancer // Hepatogastroenterology. 2004. Vol. 51 (55). P. 82–85.

15. Park J.C., Lee S.K., Seo J.H. et al. Predictive factors for local recurrence after endoscopic resection for early gastric cancer: long-term clinical outcome in a single-center experience// Surg. Endosc. 2010. Vol. 24 (11). P. 2842–2849.

16. Rebai W., Fterich F., Makni A. et al. Early gastric adenocarcinoma // Tunis Med. 2010. Vol. 88 (1). P. 1–4.

17. Sano T., Mudan S. No advantage of reoperation for positive resection margin in node positive gastric cancer patients // Jpn. J. Clin. Oncol. 1999. Vol. 29. P. 283–284.

18. Shimoyama S., Seto Y., Yasuda H. Concepts, rationale and current outcomes of less invasive surgical strategies for early gastric cancer: data from a quarter-centure of experience in a single institution // World. J. Surg. 2005. Vol. 29. P. 58–65.

19. Tsukuma H., Mishima T., Oshima A. Prospective study of “early” gastric cancer // Int. J. Cancer. 1983. Vol. 31. P. 421–426.

20. Tsukuma H., Oshima A., Narahara H. et al. Natural history of early gastric cancer: a non-current, long-term, follow-up // Gut. 2000. Vol. 47. P. 618–621.

21. Wu B., Wu D., Wang M., Wang G. Recurrence in patients following curative resection of early gastric carcinoma // J. Surg. Oncol. 2008. Vol. 98. P. 411– 414.

22. Yamamoto M., Yamanaka T., Baba H. et al. The postoperative recurrence and the occurrence of second primary carcinomas in patients with early gastric carcinoma // J. Surg. Oncol. 2008. Vol. 97. P. 231–235.

23. Yanai H., Noguchi T., Mizumachi S. et al. A blind comparison of the effectiveness of endoscopic ultrasonography and endoscopy in staging early gastric cancer // Gut. 1999. Vol. 44. P. 361–365


Review

For citations:


Turkin I.N., Davydov M.I. WHAT DEFINES THE EXTENT OF LYMPHODISSECTION FOR EARLY GASTRIC CANCER? Siberian journal of oncology. 2013;(2):12-17. (In Russ.)

Views: 545


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1814-4861 (Print)
ISSN 2312-3168 (Online)