CURRENT APPROACHES TO CONSERVATIVE AND COMBINED TREATMENT FOR LOCALLY ADVANCED LARYNGEAL CANCER
Abstract
The comparative analysis of results of conservative and combined treatment was carried out. The study group consisted of 400 patients with stage T3–4N0–3M0 laryngeal cancer who received concurrent chemotherapy and radiation therapy in combination with various physical radiomodifyers. The control group comprised 920 patients treated with the same technique but without systemic polychemotherapy. The 5-year relapse-free and overall survival rates were significantly higher in the study group than in the control group (concervative treatment: 71 % and 86 % versus 37 % and 64.8 %, respectively, р<0,001 and combined treatment: 80 % and 83 % versus 47.4 % and 52 %, respectively
(р<0,001). The functional organ was preserved in 71.2 % of locally advanced laryngeal cancer patients treated conservatively compared to 37.0 % of the control group patients. Oprgan-preserving surgeries were performed in 30.5% and 23%, respectively. The total number of patients with the larynx preservation was 50 % of the stydy group and 31.6 % of the control group.
(р<0,001). The functional organ was preserved in 71.2 % of locally advanced laryngeal cancer patients treated conservatively compared to 37.0 % of the control group patients. Oprgan-preserving surgeries were performed in 30.5% and 23%, respectively. The total number of patients with the larynx preservation was 50 % of the stydy group and 31.6 % of the control group.
About the Authors
V. A. Pankratov
Medical Radiological Research Center, Obninsk
Russian Federation
Russian Federation
V. G. Andreev
Medical Radiological Research Center, Obninsk
Russian Federation
Russian Federation
Yu. S. Mardyntsky
Medical Radiological Research Center, Obninsk
Russian Federation
Russian Federation
V. A. Rozhnov
Medical Radiological Research Center, Obninsk
Russian Federation
Russian Federation
O. K. Kurpeshev
Medical Radiological Research Center, Obninsk
Russian Federation
Russian Federation
E. D. Akki
Medical Radiological Research Center, Obninsk
Russian Federation
Russian Federation
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Review
For citations:
Pankratov V.A., Andreev V.G., Mardyntsky Yu.S., Rozhnov V.A., Kurpeshev O.K., Akki E.D. CURRENT APPROACHES TO CONSERVATIVE AND COMBINED TREATMENT FOR LOCALLY ADVANCED LARYNGEAL CANCER. Siberian journal of oncology. 2013;(2):36-40. (In Russ.)
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