LYMPHOGENIC METASTASIS IN LUMINAL-TYPE A BREASR CANCER
Abstract
The present study has found significant heterogeneity of luminal A breast cancer group, which is manifested by differences in relationship between the frequency of lymphogenic metastasis and morphologic and molecular-biological parameters of the primary tumor. The frequency of regional metastases has appeared to relate to the presence of microalveolar structures in infiltrating component of invasive ductal breast cancer and to its phenotypic variety only in menopausal patients. It can be evidence of differences in tumor pathogenesis in patients with different state of menstrual function even within one molecular-genetic tumor group. It is important to emphasize that the different variants
of clinical behavior of luminal A breast cancer are associated with morphological parameters of the tumor, allowing one to easily obtain the additional information during histological examination of bioptic material for predicting clinical course of luminal-type A breast cancer.
of clinical behavior of luminal A breast cancer are associated with morphological parameters of the tumor, allowing one to easily obtain the additional information during histological examination of bioptic material for predicting clinical course of luminal-type A breast cancer.
About the Authors
M. V. Zavjalova
Cancer Research Institute, SB RAMS, Tomsk, Siberian State Medical University, Tomsk
Russian Federation
Russian Federation
N. S. Telegina
Siberian State Medical University, Tomsk
Russian Federation
Russian Federation
S. V. Vtorushin
Cancer Research Institute, SB RAMS, Tomsk, Siberian State Medical University, Tomsk
Russian Federation
Russian Federation
V. M. Perelmute
Cancer Research Institute, SB RAMS, Tomsk, Siberian State Medical University, Tomsk
Russian Federation
Russian Federation
E. M. Slonimskaya
Cancer Research Institute, SB RAMS, Tomsk, Siberian State Medical University, Tomsk
Russian Federation
Russian Federation
E. V. Denisov
Cancer Research Institute, SB RAMS, Tomsk
Russian Federation
Russian Federation
N. V. Cherdyntseva
Cancer Research Institute, SB RAMS, Tomsk, Siberian State Medical University, Tomsk
Russian Federation
Russian Federation
S. V. Patalyak
Cancer Research Institute, SB RAMS, Tomsk
Russian Federation
Russian Federation
N. A. Skryabin
Research Institute of Medical Genetics, SB RAMS
Russian Federation
Russian Federation
K. Yu. Khristenko
Siberian State Medical University, Tomsk
Russian Federation
Russian Federation
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Review
For citations:
Zavjalova M.V., Telegina N.S., Vtorushin S.V., Perelmute V.M., Slonimskaya E.M., Denisov E.V., Cherdyntseva N.V., Patalyak S.V., Skryabin N.A., Khristenko K.Yu. LYMPHOGENIC METASTASIS IN LUMINAL-TYPE A BREASR CANCER. Siberian journal of oncology. 2013;(2):41-44. (In Russ.)
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