Nosocomial infections caused by bacteria of Enterobacteriacae family in cancer clinic
https://doi.org/10.21294/1814-4861-2019-18-1-36-42
Abstract
The purpose of the study was to analyze the prevalence of multidrug-resistant (MDR) pathogens (Escherichia coli and Klebsiella pneumonia) isolated from cancer patients. material and methods. 862 strains of E. coli and 1 461 strains of K. pneumoniae isolated from wound, blood, urine and other pathological materials from cancer patients treated at N.N. Blokhin National Medical Research Center of Oncology (Moscow) between 2014 and 2016 were analyzed. results. Over the last 3 years, there has been a significant increase in the number of E.coli resistant to piperacillin-tazobactam (from 8.1 to 25 %), ceftriaxone (from 15.7 to 100 %), ertapenem (from 8.1 to 97.7 %), and amikacin (c 4.5 to 14.6 %). The number of E. coli producing carbapenemases has increased from 5.8 to 20.8 % (p≤0.0001). Among K. pneumoniae, a significant increase in the number of strains resistant to piperacillin-tazobactam (from 59.7 to 89.7 %), ceftazidime (from 62.8 to 82.8 %), ceftriaxone (from 62.8 to 100 %), cefepime (from 63.1 to 83.8 %), ertapenem (from 62.1 to 100 % ), imipenem (from 30.0 to 81.0 %), and meropenem (from 53.9 to 86.8% ) is observed. conclusion. Evaluation of the frequency of isolation of MDR microorganisms over time is an essential element of epidemiological surveillance and is necessary for the correct treatment of patients with infectious complications.
About the Authors
N. V. Dmitrieva
N.N. Blokhin National Medical Research Center of Oncology
Russian Federation
Russian Federation
Natalia V. Dmitrieva, MD, DSc, Professor, Head of the Laboratory of Microbiological Diagnostics and Management of Infections in Cancer Patients.
Author ID (Scopus): 56338598600
24, Kashirskoe shosse, 115478-Moscow
V. V. Aginova
N.N. Blokhin National Medical Research Center of Oncology;
Medical college No1
Russian Federation
Russian Federation
Viktoria V. Aginova, lecturer, Medical college No1.
24, Kashirskoe shosse, 115478-Moscow
6, Chuksin tupik, 127206-Moscow
I. N. Petukhova
N.N. Blokhin National Medical Research Center of Oncology
Russian Federation
Russian Federation
Irina N. Petukhova, MD, DSc, Leading Research Scientist, Laboratory of Microbiological Diagnostics and Management of Infections in Cancer Patients.
Author ID (Scopus): 6701329760.
24, Kashirskoe shosse, 115478-Moscow
Z. V. Grigorievskaya
N.N. Blokhin National Medical Research Center of Oncology
Russian Federation
Russian Federation
Zlata V. Grigorievskaya, MD, DSc, Senior Researcher, Laboratory of Microbiological Diagnostics and Management of Infections in Cancer Patients.
Author ID (Scopus): 57200538935.
24, Kashirskoe shosse, 115478-Moscow
А. I. Dmitrieva
N.N. Blokhin National Medical Research Center of Oncology
Russian Federation
Russian Federation
Anna I. Dmitrieva, Laboratory Assistant, Microbiological Diagnostics and Management of Infections in Cancer Patients.
24, Kashirskoe shosse, 115478-Moscow
N. S. Bagirova
N.N. Blokhin National Medical Research Center of Oncology
Russian Federation
Russian Federation
Natalia S. Bagirova, MD, DSc, Leading Research Scientist, Laboratory of Microbiological Diagnostics and Management of Infections in Cancer Patients.
Author ID (Scopus): 6603332319.
24, Kashirskoe shosse, 115478-Moscow
I. V. Tereshchenko
N.N. Blokhin National Medical Research Center of Oncology
Russian Federation
Russian Federation
Inna V. Tereshchenko, Research Fellow, Laboratory of Microbiological Diagnostics and Management of Infections in Cancer Patients.
Author ID (Scopus): 57193277015.
24, Kashirskoe shosse, 115478-Moscow
Е. N. Khmaladze
N.N. Blokhin National Medical Research Center of Oncology
Russian Federation
Russian Federation
Elena N. Khmaladze, Deputy Chief Physician.
24, Kashirskoe shosse, 115478-Moscow
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Review
For citations:
Dmitrieva N.V., Aginova V.V., Petukhova I.N., Grigorievskaya Z.V., Dmitrieva А.I., Bagirova N.S., Tereshchenko I.V., Khmaladze Е.N. Nosocomial infections caused by bacteria of Enterobacteriacae family in cancer clinic. Siberian journal of oncology. 2019;18(1):36-42. (In Russ.) https://doi.org/10.21294/1814-4861-2019-18-1-36-42
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