SOLID PSEUDOPAPILLARY TUMOR OF THE PANCREAS IN A MAN: A CASE REPORT
https://doi.org/10.21294/1814-4861-2019-18-5-113-117
Abstract
Background. Solid pseudopapillary tumor of the pancreas is a rare neoplasm, accounting for only 1–2 % of all pancreatic neoplasms and having a tendency to affect mainly young women.
Material and methods. We report a case of a solid pseudopapillary tumor of the pancreas in a 28-year-old man treated with laparoscopic distal pancreatectomy in Moscow Botkin Hospital.
Results. The tumor was discovered incidentally by routine survey ultrasound or computed tomography of the abdomen. The patient underwent distal pancreatectomy with splenectomy. The immunohistochemical study showed a pronounced positive nuclear staining for β-catenin and progesterone and a negative staining for chromogranin A and synaptophysin, thus confirming the presence of solid pseudopapillary tumor of the pancreas.
Conclusion. In case of pancreatic tumor, even in male patients, a solid pseudopapillary tumor must be considered in the differential diagnosis. Surgical strategies should be based on the location, size of the tumor and the involvement of adjacent organs, because R0-resection with a solid pseudopapillary tumor leads to a good 5-year survival.
About the Authors
A. V. Shabunin
S.P. Botkin Municipal Clinical Hospital;
Russian Medical Academy of Postgraduate Education
Russian Federation
Russian Federation
Alexey V. Shabunin, MD, Professor, Corresponding Member of Russian Academy of Sciences, Head of Surgery Department, Russian Medical Academy of Continues Professional Education; Head Physician of S.P. Botkin Municipal Clinical Hospital
5, 2-nd Botkinsky proezd, Moscow-125284,
2/1 Barrikadnaya Street, Moscow-125993
Researcher ID (WOS): W-1068-2017
M. M. Tavobilov
S.P. Botkin Municipal Clinical Hospital;
Russian Medical Academy of Postgraduate Education
Russian Federation
Russian Federation
Mikhail M. Tavobilov, MD, DSc, Surgery Department, Russian Medical Academy of Continues Professional Education; Head of the Department of Hepatobiliary and Pancreatic Surgery, S.P. Botkin Municipal Clinical Hospital
5, 2-nd Botkinsky proezd, Moscow-125284,
2/1 Barrikadnaya Street, Moscow-125993
O. V. Paklina
S.P. Botkin Municipal Clinical Hospital
Russian Federation
Russian Federation
Oksana V. Paklina, MD, Professor, Head of Anatomic Pathology Department
5, 2-nd Botkinsky proezd, Moscow-125284
G. R. Setdikova
S.P. Botkin Municipal Clinical Hospital
Russian Federation
Russian Federation
Galia R. Setdikova, MD, PhD, Pathologist, Anatomic Pathology Department
5, 2-nd Botkinsky proezd, Moscow-125284
A. A. Karpov
S.P. Botkin Municipal Clinical Hospital
Russian Federation
Russian Federation
Alexey A. Karpov, MD, PhD, Surgeon, Department of Hepatobiliary and Pancreatic Surgery
5, 2-nd Botkinsky proezd, Moscow-125284
D. S. Ozerova
Russian Medical Academy of Postgraduate Education
Russian Federation
Russian Federation
Daria S. Ozerova, MD, Resident, Surgery Department
2/1 Barrikadnaya Street, Moscow-125993
References
1. Papavramidis T., Papavramidis S. Solid pseudopapillary tumors of the pancreas: review of 718 patients reported in English literature. J Am Coll Surg. 2005; 200(6): 965–972. doi: 10.1016/j.jamcollsurg.2005.02.011.
2. Guo N., Zhou Q.B., Chen R.F., Zou S.Q., Li Z.H., Lin Q., Wang J., Chen J.S. Diagnosis and surgical treatment of solid pseudopapillary neoplasm of the pancreas: analysis of 24 cases. Can J Surg. 2011 Dec; 54(6): 368–74. doi: 10.1503/cjs.011810.
3. Frantz V.K. Tumors of the pancreas. Atlas of Tumor Pathology, VII. Fascicles 27 and 28. Armed Forced Institute of Pathology, Washington, DC, 1959. 32–33.
4. Nishihara K., Nagoshi M., Tsuneyoshi M., Yamaguchi K., Hayashi I. Papillary cystic tumors of the pancreas: assessment of their malignant potential. Cancer. 1993; 71(1): 82–92.
5. Zinner M.J., Shurbaji M.S., Cameron J.L. Solid and papillary epithelial neoplasms of the pancreas. Surgery. 1990 Sep; 108(3): 475–80.
6. Klöppel G., Luttges J., Klimstra D.S., Hamilton S.R. Pathology and genetics of tumours of the digestive system. Lyon: IARC press, 2000. 48.
7. Sperti C., Berselli M., Pasquali C., Pastorelli D., Pedrazzoli S. Aggressive behaviour of solid-pseudopapillary tumor of the pancreas in adults: a case report and review of the literature. World J Gastroenterol. 2008 Feb 14; 14(6): 960–5. doi: 10.3748/wjg.14.960.
8. Machado M.C., Machado M.A., Bacchella T., Jukemura J., Almeida J.L., Cunha J.E. Solid pseudopapillary neoplasm of the pancreas: distinct patterns of onset, diagnosis, and prognosis for male versus female patients. Surgery. 2008 Jan; 143(1): 29–34. doi: 10.1016/j.surg.2007.07.030.
9. Matos J.M., Grützmann R., Agaram N.P., Saeger H.D., Kumar H.R., Lillemoe K.D., Schmidt C.M. Solid pseudopapillary neoplasms of the pancreas: a multi-institutional study of 21 patients. J Surg Res. 2009 Nov; 157(1): e137–42. doi: 10.1016/j.jss.2009.03.091.
10. Baek J.H., Lee J.M., Kim S.H., Kim S.J., Kim S.H., Lee J.Y., Han J.K., Choi B.I. Small (≤3 cm) solid pseudopapillary tumors of the pancreas at multiphasic multidetector CT. Radiology. 2010 Oct; 257(1): 97–106. doi: 10.1148/radiol.10092089.
11. Ansari N.A., Ramalho M., Semelka R.C., Buonocore V., Gigli S., Maccioni F. Role of magnetic resonance imaging in the detection and characterization of solid pancreatic nodules: An update. World J Radiol. 2015 Nov 28; 7(11): 361–74. doi: 10.4329/wjr.v7.i11.361.
12. Kim M.J., Jang S.J., Yu E. Loss of E-cadherin and cytoplasmicnuclear expression of β-catenin are the most useful immunoprofiles in the diagnosis of solid-pseudopapillary neoplasm of the pancreas. Hum Pathol. 2008 Feb; 39(2): 251–8. doi: 10.1016/j.humpath.2007.06.014.
13. Huang H.L., Shih S.C., Chang W.H., Wang T.E., Chen M.J., Chan Y.J. Solid-pseudopapillary tumor of the pancreas: clinical experience and literature review. World J Gastroenterol. 2005 Mar 7; 11(9): 1403–9. doi: 10.3748/wjg.v11.i9.1403.
14. Kim M.J., Choi D.W., Choi S.H., Heo J.S., Sung J.Y. Surgical treatment of solid pseudopapillary neoplasms of the pancreas and risk factors for malignancy. Br J Surg. 2014 Sep; 101(10): 1266–71. doi: 10.1002/bjs.9577.
Review
For citations:
Shabunin A.V., Tavobilov M.M., Paklina O.V., Setdikova G.R., Karpov A.A., Ozerova D.S. SOLID PSEUDOPAPILLARY TUMOR OF THE PANCREAS IN A MAN: A CASE REPORT. Siberian journal of oncology. 2019;18(5):113-117. (In Russ.) https://doi.org/10.21294/1814-4861-2019-18-5-113-117
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