QUALITY OF LIFE IN PATIENTS WITH LARYNGEAL AND LARYNGOPHARYNGEAL CANCER IN SHORT-AND LONG-TERM FOLLOW-UP
Abstract
The study included 96 patients with morphologically verified squamous cell carcinoma of larynx and laryngopharynx T2–4N0–2M0 stage of the tumor process who were administered two courses of neoadjuvant chemotherapy at 3–4 weeks interval by the scheme paclitaxel 175 mg/m2, carboplatin AUC-6 plus radiotherapy in the regimen of multifractionated radiation dose of 1.3 Gy twice a day at 4 hours interval. In case of complete regression of the tumor (n=33) radiotherapy was performed to the accumulated radical dose of 65 isoGy. The next stage in partial regression and stabilization of the process (n=63) was radical surgical intervention. EORTC QLQ-30 and QLQ – H&N35 questionnaires were used to estimate quality of life of the patients. Quality of life as a criterion for the assessment of treatment efficacy was correlated with a significant increase in the 2-year overall and disease-free survival in patients who received chemoradiotherapy compared to those who underwent combined modality treatment including surgery. Changes in the values of EORTC QLQ-30 and QLQ – H & N35 modules clearly indicate the relationship between the quality of life measures and treatment methods.
About the Authors
S. Yu. Chizhevskaya
Tomsk Cancer Research Institute
Russian Federation
Chizhevskaja Svetlana Jurevna - MD, DSc., Senior Researcher, Department head and neck tumors.
Тел.:+7(3822)41-80-62. E-mail: sch@oncology.tomsk.ru
Russian Federation
Chizhevskaja Svetlana Jurevna - MD, DSc., Senior Researcher, Department head and neck tumors.
Тел.:+7(3822)41-80-62. E-mail: sch@oncology.tomsk.ru
Е. L. Choinzonov
Siberian State Medical University, Tomsk
Russian Federation
Russian Federation
Choynzonov Evgeny Lhamatsirenovich - MD, DSc, Academician of RAS, Professor, Director of the Tomsk Cancer Research Institute.
Phone: +7 3822 51-10-39. E-mail: nii@oncology.tomsk.ru
L. N. Balatskaya
Tomsk Cancer Research Institute
Russian Federation
Russian Federation
Balatskaya Lidija Nikolaevna - DSc, Principal Investigator, Department head and neck tumors ,Tomsk Cancer Research Institute. Phone: +7(3822)42-00-53. E-mail: balatskaya@oncology.tomsk.ru
References
1. Balatskaya L.N., Kicmanjuk Z.D., Chizhevskaya S.Y. The current state of rehabilitation of head and neck cancer patients // Sibirskij onko logicheskij zhurnal. 2002. № 1. P. 50–53. [in Russian]
2. Balatskaya L.N., Choinzonov E.L. Quality of life of cancer patients as a criterion of assessment of efficacy of treatment and rehabilitation // Si birskij vestnik psihiatrii i narkologii. 2008. № 3. P. 36–37. [in Russian]
3. Bondarenko V.P., Kvasov A.N., Konev A.A., Meshcheryakov R.V., Choinzonov E.L., Chizhevskaya S.Y. Software for speech signal research in patients with malignant diseases of the throat // Medicinskaja tehnika. 2009. № 4. P. 33–37. [in Russian]
4. Guzev A.N. Structural and dynamic analysis and principles of pathogenetic therapy of borderline neuro-psychiatric disorders in oncology practice: Abstract of DSc thesis. Tomsk, 1990. 25 p. [in Russian]
5. Davydov M.I., Aksel’ E.M. Cancer incidence statistics in Russia and the CIS in 2007. // Vestnik Rossijskogo onkologicheskogo nauchnogo centra im. N.N. Blohina RAMN. Vol. 20 (3). Suppl. 1. 2009. 158 p. [in Russian]
6. Muhamedov M.R., Cheremisina O.V., Choynzonov E.L., Kulbakin D.E., Balatskaya L.N., Vasiliev N.V., Gunther V.E. The modern view on complex approach when diagnosing, treating and aftercaring in larynx cancer patients // Rossijskaja otorinolaringologija. 2012. № 3. P. 78–84. [in Russian]
7. Novik A.A., Ionova T.I. Guidelines for Life Quality in medicine/ Ed. by Ju.L. Shevchenko. M., 2007. 320 p. [in Russian] 8. Reshetov I.V., Chissov V.I., Trofimov E.I. Laryngopharyngeal cancer. M., 2005. 300 p. [in Russian]
8. Taptapova S.L. Restoration of vocal function in patients after resec- tion or removal of the larynx. М., 1985. 92 p. [in Russian]
9. Chissov V.I., Starinskij V.V., Petrova G.V. Cancer incidence in Rus- sia in 2008 (morbidity and mortality). M., 2010. 256 p. [in Russian]
10. Choinzonov E.L., Balatskaya L.N. Life quality of cancer patients // Tomsk: Pechatnaja manufaktura, 2011. 152 p. [in Russian]
11. Boyle P., Levin B. World cancer report 2008. Lyon: International Agency for Research on Cancer. 2008. 511 p.
12. Woodard T.D., Oplatek A., Petruzzelli G.J. Life After Total Laryn- gectomy. A Measure of Long-term Survival, Function, and Quality of Life // Arch Otolaryngol. Head Neck Surg. 2007. Vol. 133 (6). P. 526–532.
Review
For citations:
Chizhevskaya S.Yu., Choinzonov Е.L., Balatskaya L.N. QUALITY OF LIFE IN PATIENTS WITH LARYNGEAL AND LARYNGOPHARYNGEAL CANCER IN SHORT-AND LONG-TERM FOLLOW-UP. Siberian journal of oncology. 2015;1(2):15-22. (In Russ.)
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