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EPIDEMIOLOGY AND CLINICO-DEMOGRAPHIC CHARACTERISTICS OF DIFFUSE LARGE B-CELL LYMPHOMA IN THE NOVOSIBIRSK CITY

https://doi.org/10.21294/1814-4861-2021-20-1-5-15

Abstract

Background. The annual reporting forms for malignant neoplasms do not provide for the division of lymphomas into variants. In international publications and statistical reference books of the Russian Federation, variants of non-Hodgkin’s lymphomas (NHL) are also not separated. For these reasons, a detailed assessment of the epidemiology of NHL in Russia is difficult, and data for individual variants of the disease are not provided.

Purpose: to present the clinical and epidemiological characteristics of Diffuse Large B-cell Lymphoma (DL BCL ) in Novosibirsk according to the data of the City Hematology Center (CHC).

Material and Methods. A retrospective analysis of primary medical documentation (case histories,  outpatient charts, and immunohistochemical study reports) of 271 patients with DL BCL was performed in the period from January 1, 2013 to December 31, 2018.

Results. The calculated registered primary morbidity and mortality from DL BCL in Novosibirsk for the analyzed years fluctuated slightly. The average incidence and mortality rates were 2.85 and 1.98 per 100,000 population, respectively. When analyzing the dynamics of the prevalence of DL BCL in Novosibirsk, a positive trend of annual increase in the indicator was revealed: 1.87 times over the past 6 years. In men, the tumor developed 2.6 years earlier than in women. In General, the risk of getting DL BCL after 50 years was 3 times higher than at the age of 30 years. Among patients diagnosed with primary lymphoma who underwent treatment at the Hematology department of CHC, half of the patients had DL BCL .Evaluation of the clinical characteristics showed a pronounced severity of the analyzed cohort.

Conclusion. The updated quantitative and qualitative indicators of clinical and epidemiological characteristics of DL BCL in Novosibirsk for 2013–18 were obtained. These indicators can be used for further monitoring, development and implementation of measures for the prevention, diagnosis and treatment of this form of hemoblastosis. 

About the Authors

E. N. Voropaeva
Research institute of internal and preventive medicine – Branch of Federal Research center institute of cytology and genetics of siberian Branch of the Russian academy of sciences
Russian Federation

MD, DSc, Senior Researcher, Laboratory of Molecular Genetic Studies of Therapeutic Diseases

Researcher ID (WOS): A-5360-2014. Author ID (Scopus): 36020818100

175/1, Boris Bogatkov street, 630089, Novosibirsk, Russia



A. A. Gurageva
Research institute of internal and preventive medicine – Branch of Federal Research center institute of cytology and genetics of siberian Branch of the Russian academy of sciences
Russian Federation

Junior Researcher, Laboratory of Molecular Genetic Studies of Therapeutic Diseases

175/1, Boris Bogatkov street, 630089, Novosibirsk, Russia




T. I. Pospelova
Novosibirsk State Medical University of the Russian Ministry of Health
Russian Federation

MD, DSc, Professor, Head of the Department of Therapy, Hematology and Transfusiology,  (Novosibirsk, Russia).

Author ID (Scopus): 7005792562

52, Red prospect, 630091, Novosibirsk, Russia



M. A. Kolesnikova
Novosibirsk Region city clinical Hospital No. 2
Russian Federation

MD, Head of the Clinical and Diagnostic Department of Hematology

21, polzunova street, 630051, Novosibirsk, Russia




M. I. Voevoda
Research institute of internal and preventive medicine – Branch of Federal Research center institute of cytology and genetics of siberian Branch of the Russian academy of sciences; Novosibirsk State Medical University of the Russian Ministry of Health
Russian Federation

MD, Professor, Member of the Russian Academy of Sciences, Director

Researcher ID (WOS): N-6713-2015. Author ID (Scopus): 7004003785

175/1, Boris Bogatkov street, 630089, Novosibirsk, Russia

52, Red prospect, 630091, Novosibirsk, Russia



V. N. Maksimov
Research institute of internal and preventive medicine – Branch of Federal Research center institute of cytology and genetics of siberian Branch of the Russian academy of sciences; Novosibirsk State Medical University of the Russian Ministry of Health
Russian Federation

MD, DSC, Professor, Head of the Laboratory of Molecular-genetic Methods for the Study of Therapeutic Diseases

Researcher ID (WOS): H-7676-2012. Author ID (Scopus): 7202540327

175/1, Boris Bogatkov street, 630089, Novosibirsk, Russia

52, Red prospect, 630091, Novosibirsk, Russia



O. V. Berezina
Novosibirsk State Medical University of the Russian Ministry of Health
Russian Federation

MD, PhD, Department of Therapy, Hematology and Transfusiology

Author ID (Scopus): 36605828400

52, Red prospect, 630091, Novosibirsk, Russia





K. V. Khalzov
Novosibirsk State Medical University of the Russian Ministry of Health; ministry of Health of Novosibirsk region
Russian Federation

MD, PhD, Minister of Health of Novosibirsk region

52, Red prospect, 630091, Novosibirsk, Russia

18, street Red avenue, 630007, Novosibirsk, Russia



M. I. Churkina
Novosibirsk State Medical University of the Russian Ministry of Health
Russian Federation

student

52, Red prospect, 630091, Novosibirsk, Russia





I. N. Nechunaeva
Novosibirsk Region city clinical Hospital No. 2
Russian Federation

MD, PhD

21, polzunova street, 630051, Novosibirsk, Russia




E. V. Melnichenko
Novosibirsk Region city clinical Hospital No. 2
Russian Federation

MD, Clinical and Diagnostic Department of Hematology

21, polzunova street, 630051, Novosibirsk, Russia




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Review

For citations:


Voropaeva E.N., Gurageva A.A., Pospelova T.I., Kolesnikova M.A., Voevoda M.I., Maksimov V.N., Berezina O.V., Khalzov K.V., Churkina M.I., Nechunaeva I.N., Melnichenko E.V. EPIDEMIOLOGY AND CLINICO-DEMOGRAPHIC CHARACTERISTICS OF DIFFUSE LARGE B-CELL LYMPHOMA IN THE NOVOSIBIRSK CITY. Siberian journal of oncology. 2021;20(1):5-15. (In Russ.) https://doi.org/10.21294/1814-4861-2021-20-1-5-15

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ISSN 1814-4861 (Print)
ISSN 2312-3168 (Online)