MRI IN THE ASSESSMENT OF TUMOR RESPONSE TO CHEMORADIOTHERAPY IN PATIENTS WITH LOCALLY ADVANCED CERVICAL CANCER
Abstract
Objective: to evaluate the ability of high-field MRI to assess tumor response to chemoradiotherapy in patients with locally advanced cervical cancer. Material and methods. The study involved 43 patients. MRI was performed using a 1.5 Tesla MAGNETOM ESSENZA scanner (SIEMENS, Germany) with a magnetic field strength of 1.5 T. Intravenous bolus injection of paramagnetic contrast agent was used to assess the tumor spread and determine the tumor boundaries and its structure. Dynamic series of sections and delayed scans in standard T1-weighted sequence were obtained. Results. Dynamic contrast-enhanced MRI was shown to be a highly informative method that can be used to monitor the process of combined chemotherapy and radiation therapy in the treatment of patients with cervical cancer. It permits the objective assessment of the dynamics of tumor regression, changes in tumor vascularity and regional lymph node status.
About the Authors
N. G. Trukhacheva
Tomsk Cancer Research Institute
Russian Federation
Russian Federation
Trukhacheva Natalia Gennadievna, MD, PhD, Senior Researcher, Diagnostic Imaging Department.
E-mail: nataly-tru@yandex.ru. SPIN-code:6707-6093I. G. Frolova
Tomsk Cancer Research Institute
Russian Federation
Russian Federation
Frolova Irina Georgievna, MD, Professor, Head of the Diagnostic Imaging Department.
Phone: +7 (3822) 42-00-57. E-mail: FrolovaIG@oncology.tomsk.ru. SPIN-code: 9800-9777
L. A. Kolomiets
Tomsk Cancer Research Institute;
Siberian State Medical University, Tomsk
Russian Federation
Russian Federation
Kolomiets Larisa Alexandrovna, MD, Professor, Honored Science Worker ofRussian Federation, Head of Gynecology Department.
E-mail: kolomietsla@oncology.tomsk.ru. SPIN-code: 6316-1146
A. V. Usova
Tomsk Cancer Research Institute
Russian Federation
Russian Federation
Usova Anna Vladimirovna, MD, PhD, Senior Researcher, Diagnostic Imaging Department.
E-mail: afina.tsk.gmail.com. SPIN-code: 3000-6564
E. G. Grigorjev
Tomsk Cancer Research Institute
Russian Federation
Russian Federation
Grigorjev Evgeny Gennadievich, MD, PhD, Senior Researcher, Diagnostic Imaging Department.
E-mail: adresprostoy@gmail.com. SPIN-code: 2079-2370
S. A. Velichko
Tomsk Cancer Research Institute
Russian Federation
Russian Federation
Velichko Svetlana Andreevna, MD, Professor, Principal Researcher, DiagnosticImaging Department.
SPIN-code: 3424-1996
O. N. Churuksaeva
Tomsk Cancer Research Institute
Russian Federation
Russian Federation
Churuksaeva Olga Nikolaevna, MD, DSc, Senior Researcher, Department of Gynecology with the Group of Cancer Prevention.
SPIN-code: 4769-0636
O. V. Shpileva
Tomsk Cancer Research Institute
Russian Federation
Russian Federation
Shpileva Olga Vladimirovna, Researcher, Department of Gynecology with the Group of Cancer Prevention.
SPIN-code: 1441-0681
References
1. Ashrafyan L.А., Antonova I.B., Basova О.I., Ivashina S.V., Lustik A.B., Antoshechkina M.A. Ways of the primary medical care reorganization in gynecology in the aspect of early detection of reproductive system cancer // Female reproductive system tumors. 2008. № 4. P. 57–63. [in Russian]
2. Berezovskaya T.P. Magnetic resonance imaging in the staging of cervical cancer // Problems of Oncology. 2003. Vol. 49 (2). P. 227–231. [in Russian]
3. Kanaev S.V. The principles of justification of chemoradiation therapy of malignant tumors // Practical Oncology. 2008. Vol. 9 (1). P. 1–8. [in Russian]
4. Kozachenko V.P. Current cervical cancer prevention strategies // Female reproductive system tumors. 2007. № 3. P. 47–48. [in Russian]
5. Kolomiets L.А., Churuksaeva О.N., Shpilyeva О.V., Urazova L. N., Rodicheva N. W. Distribution characteristics of different types of human papillomavirus in patients with cervical dysplasia and cervical cancer in Tomsk city // Siberian Journal of Oncology. 2012. № 3. P. 41–45. [in Russian]
6. Practical gynecological oncology: selected lectures / Eds. A.F. Urmancheeva, S.А. Tyulyandin, V.М. Moiseenko. SPb., 2008. P. 168–180. [in Russian]
7. Rubtsova N.А., Novikova Е.G., Sinitsyn V.Е. MRI in preoperative assessment of locally advanced cervical cancer // Obstetrics, gynecology, reproduction. 2012. Vol. 6 (3). P. 6–13. [in Russian]
8. Cancer statistics in Russia and CIS countries in 2012 / Eds. М.I. Davydov, Е.М. Aksel. M., 2014. [in Russian]
9. Tanriverdieva E.К., Zakharova Т.I., Barinov V.V., Zhordania К.I., Prikhodko Е.V., Mamedova Л.Т. Comparative analysis of clinical-prognostic factors of stage 1В и IIA glandular squamous cell cervical carcinoma after surgical and combined modality treatment // Palliative medicine and rehabilitation. 2012. № 4. P.18–22. [in Russian]
10. Titova V.А., Kharchenko N.V., Dobrovolskaya N.Yu., Kreinina Yu.М. Strategy and tactics of the modern radiation therapy for cancer of the uterine cervix and corpus // Problems of Oncology. 2009. № 4. P. 471–473. [in Russian]
11. Trukhacheva N.G., Frolova I.G., Kolomiets L.A. Usova A.V., Grigoryev E.G., Velichko S.A., Chernyshova A.L., Churuksaeva O.N. Assessment of cervical cancer spread using MRI // Siberian Journal of Oncology. 2015. № 2. P. 64–69. [in Russian]
12. Choinzonov Е.L., Pisareva L.F., Boyarkina А.P., Odintsova I.N., Takhauov R.М. Cancer incidence in Tomsk in 2004. Tomsk, 2004. 253 p. [in Russian]
13. Choinzonov Е.L., Pisareva L.F., Zhuikova L.D. Cancer incidence in Tomsk during 2004 to 2009. Assessment of diagnostic accuracy // Siberian Journal of Oncology. 2011. № 3. P. 29–34. [in Russian]
14. Churuksaeva О.N., Kolomiets L.А. Neoadjuvant chemotherapy for locally advanced cervical cancer // Siberian Journal of Oncology. 2013. № 2. P. 18–24. [in Russian]
15. Shavladze Z.N., Berezovskaya T.P., Proshin А.А. Clinical and diagnostic aspects of magnetic resonance imaging in staging of cervical cancer // Medical visualization. 2009. № 5 P. 80–90. [in Russian]
16. Allen D., Narayan K. Managing advanced stage cervical cancer // Best Pract. Res. Clin. Obstet. Gynaecol. 2005. Vol. 19 (4). P. 591–609.
17. Chiang S.H., Quek S.T. Carcinoma of the cervix: role of MR imaging // Ann. Acad. Med. Singapore. 2003. Vol. 32 (4). P. 550–556.
18. Choi H.J., Roh J.W., Seo S.S., Lee S., Kim J.Y., Kim S.K., Kang K.W., Lee J.S., Jeong J.Y., Park S.Y. Comparison of theaccuracy of magnetic resonance imaging and positronemission tomography/computed tomography in the presurgical detection of lymph node metastases inpatients with uterine cervical carcinoma // Cancer. 2006. Vol. 106 (4). P. 914–922. doi:10.1002/cncr.21641.
19. Hong K.S., Ju W., Choi H.J., Kim J.K., Kim M.H., Cho K.S. Differential Diagnostic Performance of Magnetic Resonance Imaging in the Detection of Lymph Node Metastases According to the Tumor Size in Early Stage Cervical Cancer Patients // Int. J. Gynecol. Cancer. 2010. Vol. 20 (5). P. 841–846. doi: 10.1111/IGC.0b013e3181db5140.
20. Hricak H., Brenner D.J., Adelstein S.J., Frush D.P., Hall E.J., Howell R.W., McCollough C.H., Mettler F.A., Pearce M.S., Suleiman O.H., Thrall J.H., Wagner L.K. Managing radiation use in medical imaging: al multifaceted challenge // Radiology. 2011. Vol. 258 (3). P. 889–905. doi:10.1148/radiol.10101157.
21. Mitchell D.G., Snyder B., Coakley F., Reinhold C., Thomas G., Amendola M.A., Schwartz L.H., Woodward P., Pannu H., Atri M., Hricak H. Early invasive cervical cancer: MRI and CT preditors of lymphatic metastases in the ACRIN 6651 / GOG 183 intergroup study // Gynecol. Oncol. 2009. Vol. 112 (1). P. 95–103. doi: 10.1016/j.ygyno.2008.10.005.
22. Naroyan K., Fisher R.J., Bernshaw D. Patterns of failureand prognostic factor analyses in locally advanced cervical cancer patients staged by magnetic resonance imaging and treated with curative intent // Int. J. Gynecol. Cancer. 2008. Vol. 18 (3). P. 525–533. doi: 10.1111/j.15251438.2007.01050.x.
23. Parker K., Gallop-Evans E., Hanna L., Adams M. Five-year experience treating locally advanced cervical cancer with concurrent chemoradiotherapy and high-dose-rate brachytherapy: results from a single institution // Int. J. Radiat. Oncol. Biol Phys. 2009. Vol. 74 (1). P. 140–146. doi: 10.1016/j.ijrobp.2008.06.1920.
24. Zand K.R., Reinhold C., Abe H., Maheshwari S., Mohamed A., Upegui D. Magnetic resonance imaging of the cervix // Cancer Imag. 2007. Vol. 28 (7). P. 69–76. doi:10.1102/1470-7330.2007.0011.
Review
For citations:
Trukhacheva N.G., Frolova I.G., Kolomiets L.A., Usova A.V., Grigorjev E.G., Velichko S.A., Churuksaeva O.N., Shpileva O.V. MRI IN THE ASSESSMENT OF TUMOR RESPONSE TO CHEMORADIOTHERAPY IN PATIENTS WITH LOCALLY ADVANCED CERVICAL CANCER. Siberian journal of oncology. 2015;1(5):84-91. (In Russ.)
Views:
792
Email this article 
