Experience of treating late cerebral lungcancer metastasis using photodynamic therapy
Abstract
Treatment outcomes for a patient with solitary brain metastasis after long-term relapse-free follow-up of invasive lung carcinoma were presented. Brain metastasis without other signs of disease progression was diagnosed 10 years after combined modality treatment for stage II lung cancer. Removal of intracerebral metastasis with intraoperative photodynamic therapy was performed. Histology microspecimens of the primary tumor and metastasis were similar. No signs of disease progression in the brain 9 months after surgery were found. This case demonstrates that it is important to increase cancer suspicion for patients with long-term relapse-free follow-up. The use of intraoperative photodynamic therapy with photoditazine as a sensitizer in the treatment of cerebral metastases results in a favorable anti-tumor effect, thus improving life quality of patients
About the Authors
A. I. Ryabova
Cancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk
Russian Federation
Russian Federation
V. A. Novikov
Cancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk
Russian Federation
Russian Federation
A. A. Zavyalov
Cancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk, Siberian State Medical University, Tomsk
Russian Federation
Russian Federation
A. Yu. Dobrodeev
Cancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk
Russian Federation
Russian Federation
S. A. Gluschenko
Cancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk
Russian Federation
Russian Federation
V. M. Perelmuter
Cancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk, Siberian State Medical University, Tomsk
Russian Federation
Russian Federation
I. G. Frolova
Cancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk
Russian Federation
Russian Federation
E. E. Bober
Cancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk
Russian Federation
Russian Federation
P. L. Surkova
Cancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk
Russian Federation
Russian Federation
K. Yu. Menshikov
Cancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk
Russian Federation
Russian Federation
References
1. Алешин В.А., Карахан В.Б., Бекяшев А.Х. и др. Церебральные метастазы рака легкого//Опухоли головы и шеи. 2011. № 4. С. 41-47
2. Белов Д.М. Онкологические принципы хирургии церебральных метастазов рака: выбор тактики в зависимости от макроструктуры: Автореф. дис.... канд. мед. наук. М., 2011. 26 с
3. Давыдов М.И., Аксель Е.М. Заболеваемость злокачественными новообразованиями населения России и стран СНГ в 2009 г.//Вестник РОНЦ им. Н.Н. Блохина РАМН. 2011. T. 22, № 3 (прил. 1). C. 54-123
4. Добродеев А. Ю., Завьялов А. А., Тузиков С. А., Миллер С. В. Рак легкого: 25-летний опыт хирургического и комбинированного лечения//Вопросы онкологии. 2010. Т. 56, № 2. С. 201-205
5. Евзиков Г.Ю., Кобяков Г.Л. Диагностика и тактика комплексного лечения метастатического поражения головного мозга. Ч. I//Нейрохирургия. 2009. № 2. С.64-70
6. Рагулин Ю.А., Медведев В.Н., Каплан М.А. и др. Возможности фотодинамической терапии в лечении рецидивов рака легкого//Сибирский онкологический журнал. 2011. № 1 (43). С. 77-79
7. Рукавичников В.М. Периферический немелкоклеточный рак легкого: современная диагностика и результаты лечения: Автореф. дис.... канд. мед. наук. М., 2009. 24 с
8. Рябуха Д.О., Горбунова Т.А., емшанов А.В., Григоров С.В. Особенности метастазирования рака легкого в головной мозг//Сибирский онкологический журнал. 2009. Прил. № 1. С. 167
9. Чиссов В.И., Филоненко Е.В., Решетов И.В. и др. Интраоперационная флюоресцентная диагностика и фотодинамическая терапия у больных с метастатическим поражением головного мозга//Российский онкологический журнал. 2011. № 2. С. 4-7
10. Celli J.P., Spring B.Q., Rizvi I. et al. Imaging and Photodynamic Therapy: Mechanisms, Monitoring and Optimization//Chem. Rev. 2010. Vol. 110 (5). P. 2795-2838
11. Eichler A.F., Chung E., Kodack D.P. et al. The biology of brain metastases -translation to new therapies//Nat. Rev. Clin. Oncol. 2011. Vol. 8 (6). P. 344-356
12. Heuvers M.E., Hegmans J.P., Stricker B.H., Aerts J.G. Improving lung cancer survival; time to move on//BMC Pulm. Med. 2012. № 12. P. 77
13. Kamp M.A., Dibué M., Santacroce A. et al. The tumour is not enough or is it? Problems and new concepts in the surgery of cerebral metastases//Ecancermedicalscience. 2013. Vol. 7. P. 306
14. Maeda R., Yoshida J., Hishida T. et al. Late Recurrence of Non-Small Cell Lung Cancer More Than 5 Years After Complete Resection: Incidence and Clinical Implications in Patient Follow-up//Chest. 2010. Vol. 138 (1). Р. 145-150
15. Mollberg N., Surati M., Demchuk C. et al. Mind-Mapping for Lung Cancer: Towards a Personalized Therapeutics Approach//Adv. Ther. 2011. Vol. 28 (3). P. 173-194
16. Okada M., Nishio W., Sakamoto T. et al. Long-term survival and prognostic factors of five-year survivors with complete resection of non-small cell lung carcinoma//J. Thor. Cardiovasc. Surg. 2003. Vol. 126 (2). Р. 558-562
17. Pizova K., Tomankova K., Daskova A. et al. Photodynamic therapy for enhancing antitumour immunity//Biomed. Pap. Med. Fac. Univ. Palacky Olomouc. Czech. Repub. 2012. Vol. 156 (2). Р. 93-102
18. Siegel R., Naishadham D., Jemal A. Cancer Statistics, 2012//CA: A Cancer Journal for Clinicians. 2012. Vol. 62 (1). Р.10-29
Review
For citations:
Ryabova A.I., Novikov V.A., Zavyalov A.A., Dobrodeev A.Yu., Gluschenko S.A., Perelmuter V.M., Frolova I.G., Bober E.E., Surkova P.L., Menshikov K.Yu. Experience of treating late cerebral lungcancer metastasis using photodynamic therapy. Siberian journal of oncology. 2013;(5):66-69. (In Russ.)
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