Cryobiopsy in morphological verification of central lung cancer with necrosis
I. S. Mamenko,
I. V. Vasilev,
G. S. Belyaev,
M. M. Mortada,
A. O. Nefedov,
T. A. Novitskaya,
P. K. Yablonskiy https://doi.org/10.21294/1814-4861-2023-22-2-103-111
Abstract
Background. The diagnostic yield of a standard forceps biopsy for central lung cancer is 74 %. However, the diagnostic value is significantly reduced in the presence of necrosis in the tumor. In Russia, cryobiopsy for central lung cancer diagnosis is currently used only in a few clinical centers.
The purpose of this study is to present a series of clinical cases showing the effectiveness of the cryobiopsy method in the morphological verification of central neoplasms with necrosis.
Description of clinical cases. The article presents 3 clinical cases of patients with central lung cancer, in which standard forceps biopsy was ineffective due to the presence of severe necrosis in the tumor. The cryobiopsy performed at the second stage made it possible in all cases to obtain a suffcient amount of morphological material for histological and immunohistochemical studies and to reconalize the lumens of the large bronchi.
Conclusion. Cryobiopsy is an effective and safe method of morphological verification of central lung cancer, which has an advantage over standard forceps biopsy, especially in the presence of a visible necrotic component in the tumor structure.
About the Authors
I. S. Mamenko
Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Health of the Russia
Russian Federation
Russian Federation
Igor S. Mamenko, MD, Endoscopist,
2–4, Ligovsky Ave., 191036, St. Petersburg
I. V. Vasilev
Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Health of the Russia
Russian Federation
Russian Federation
Igor V. Vasiliev, MD, PhD, Leading Researcher, Interventional Pulmonology, Thoracic Surgeon,
2–4, Ligovsky Ave., 191036, St. Petersburg
G. S. Belyaev
Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Health of the Russia
Russian Federation
Russian Federation
Gleb S. Belyaev, MD, Endoscopist,
2–4, Ligovsky Ave., 191036, St. Petersburg
M. M. Mortada
Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Health of the Russia
Russian Federation
Russian Federation
Makhmud M. Mortada, MD, Oncologist, Thoracic Surgeon,
2–4, Ligovsky Ave., 191036, St. Petersburg
A. O. Nefedov
Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Health of the Russia
Russian Federation
Russian Federation
Andrei O. Nefedov, MD, PhD, Senior Researcher, Head of the Department of Thoracic Oncology,
2–4, Ligovsky Ave., 191036, St. Petersburg
T. A. Novitskaya
Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Health of the Russia;
Saint-Petersburg State University
Russian Federation
Russian Federation
Tatyana A. Novitskaya, MD, PhD, Head of the Department of Pathological Anatomy, 2–4, Ligovsky Ave., 191036, St. Petersburg;
Associate Professor, Department of Pathology, 7–9, Universitetskaya Qy., 199034, St. Petersburg
P. K. Yablonskiy
Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Health of the Russia;
Saint-Petersburg State University
Russian Federation
Russian Federation
Petr K. Yablonskiy, MD, Professor, 2–4, Ligovsky Ave., 191036, St. Petersburg;
Vice-Rector, Professor of the Department of Hospital Surgery, Faculty of Medicine, 7–9, Universitetskaya Qy., 199034, St. Petersburg
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Review
For citations:
Mamenko I.S., Vasilev I.V., Belyaev G.S., Mortada M.M., Nefedov A.O., Novitskaya T.A., Yablonskiy P.K. Cryobiopsy in morphological verification of central lung cancer with necrosis. Siberian journal of oncology. 2023;22(2):103-111. (In Russ.) https://doi.org/10.21294/1814-4861-2023-22-2-103-111
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