Thyroid metastasis from nasopharyngeal cancer: a case report
D. M. Fatkullin,
A. O. Guz,
A. V. Garev,
A. S. Zakharov,
M. I. Sokolova,
I. G. Shesler,
K. S. Aristarkhova https://doi.org/10.21294/1814-4861-2023-22-4-149-153
Abstract
Background. Nasopharyngeal cancer is a rare head and neck cancer with a relatively high risk of locoregional recurrence and distant metastases. The most common sites of metastases are bones (70–80 %) followed by liver (30 %), lung (18 %), and lymph node (axillary, mediastinal, pelvic, and inguinal). Thyroid gland is an uncommon site of metastasis with an incidence ranging from 0.5% to 24 %. Thyroid metastasis from nasopharyngeal cancer has been reported in only 9 cases in the world literature and no one in Russia.
Case report. We report a case of thyroid metastasis from nasopharyngeal cancer found incidentally in a 53-year-old female patient.
Conclusion. Metastases to the thyroid gland are rare, and patients with metastatic thyroid disease rarely present with organ-specifc symptoms, thus raising diagnostic diffculties for both clinicians and the pathologists. This clinical report demonstrates the diffculties of differential diagnosis,as well as the importance of a thorough collection of complaints, anamnesis, and clinical examination.
About the Authors
D. M. Fatkullin
Chelyabinsk Regional Clinical Center of Oncology and Nuclear Medicine
Russian Federation
Russian Federation
Dmitry M. Fatkullin, MD, Oncologist, Head and Neck Tumor Department
42, Bluchera St., 454087, Chelyabinsk
A. O. Guz
Chelyabinsk Regional Clinical Center of Oncology and Nuclear Medicine
Russian Federation
Russian Federation
Alexander O. Guz, MD, Oncologist, Head of Head and Neck Tumor Department
42, Bluchera St., 454087, Chelyabinsk
A. V. Garev
Chelyabinsk Regional Clinical Center of Oncology and Nuclear Medicine
Russian Federation
Russian Federation
Artem V. Garev, MD, Oncologist, Head and Neck Tumor Department
42, Bluchera St., 454087, Chelyabinsk
A. S. Zakharov
Chelyabinsk Regional Clinical Center of Oncology and Nuclear Medicine
Russian Federation
Russian Federation
Alexander S. Zakharov, MD, Oncologist, head and neck tumor department, Head of the emergency room
42, Bluchera St., 454087, Chelyabinsk
M. I. Sokolova
Chelyabinsk Regional Clinical Center of Oncology and Nuclear Medicine
Russian Federation
Russian Federation
Maria I. Sokolova, MD, Head and Neck Oncologist
42, Bluchera St., 454087, Chelyabinsk
I. G. Shesler
Chelyabinsk Regional Clinical Center of Oncology and Nuclear Medicine
Russian Federation
Russian Federation
Irina G. Shesler, MD, Pathologist
42, Bluchera St., 454087, Chelyabinsk
K. S. Aristarkhova
Chelyabinsk Regional Clinical Center of Oncology and Nuclear Medicine
Russian Federation
Russian Federation
Ksenia S. Aristarhova, MD, PhD, Pathologist, Head of Diagnostics Laboratory
42, Bluchera St., 454087, Chelyabinsk
References
1. Global Cancer Obserbvatory. Cancer Today. [cited 2023 Jun 1]. URL: http://gco.iarc.fr.
2. Petrova G.V., Starinskiy V.V., Gretzova O.P. Head and neck malignancies in Russia (Statistical review). Head and Neck. 2015; (4): 41–44. (in Russian).
3. Al-Sarraf M., LeBlanc M., Giri P.G., Fu K.K., Cooper J., Vuong T., Forastiere A.A., Adams G., Sakr W.A., Schuller D.E., Ensley J.F. Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: phase III randomized Intergroup study 0099. J Clin Oncol. 1998; 16(4): 1310–7. doi: 10.1200/JCO.1998.16.4.1310.
4. Lee A.W., Poon Y.F., Foo W., Law S.C., Cheung F.K., Chan D.K., Tung S.Y., Thaw M., Ho J.H. Retrospective analysis of 5037 patients with nasopharyngeal carcinoma treated during 1976–1985: overall survival and patterns of failure. Int J Radiat Oncol Biol Phys. 1992; 23(2): 261–70. doi: 10.1016/0360-3016(92)90740-9.
5. Ng W.T., Lee M.C., Hung W.M., Choi C.W., Lee K.C., Chan O.S., Lee A.W. Clinical outcomes and patterns of failure after intensity-modulated radiotherapy for nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys. 2011; 79(2): 420–8. doi: 10.1016/j.ijrobp.2009.11.024.
6. Lam K.Y., Lo C.Y. Metastatic tumors of the thyroid gland: a study of 79 cases in Chinese patients. Arch Pathol Lab Med. 1998; 122(1): 37–41.
7. Takashima S., Saeki H., Moriwaki S., Yamamoto Y. [An autopsy case of metastatic thyroid tumor]. Gan No Rinsho. 1984; 30(8): 880–4. Japanese.
Review
For citations:
Fatkullin D.M., Guz A.O., Garev A.V., Zakharov A.S., Sokolova M.I., Shesler I.G., Aristarkhova K.S. Thyroid metastasis from nasopharyngeal cancer: a case report. Siberian journal of oncology. 2023;22(4):149-153. (In Russ.) https://doi.org/10.21294/1814-4861-2023-22-4-149-153
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