Sclerosing mucoepidermoid thyroid carcinoma combined with autoimmune thyroiditis
https://doi.org/10.21294/1814-4861-2023-22-4-154-158
Abstract
Background. Sclerosing mucoepidermoid thyroid carcinoma (SMTC) is a recently recognized malignant neoplasm of the thyroid. SMTC was frst reported in 1991. It arises in a background of Hashimoto thyroiditis (HT). There are two variants of mucoepidermoid carcinoma of thyroid gland: the conventional and sclerosing variants. SMTC has recently been recognized as a separate disease entity by World Health Organization (WHO).
Description of the clinical case. We present the case of a 51-year-old woman with a 2-year history of autoimmune thyroiditis with a thyroid nodule. The patient had no symptoms or signs of compression. The level of thyroid–stimulating hormone (TSH) was 15.8 (range 0.4-4.0), antibodies to peroxidase: 150 Iu/ml. Scintigraphy of the thyroid gland revealed a dominant cold nodule (1.5×2 cm) in the right lobe of the gland. The control ultrasound examination showed negative fndings. Fine needle aspiration cytology of the nodule revealed follicular lesion in a background of TH. Extrafascial thyroidectomy was performed. The patient was followed up for 10 months.
About the Author
E. V. Ryabchenko
Center for Endocrine Surgery, Krasnodar Regional Clinical Hospital No. 2
Russian Federation
Russian Federation
Evgeny V. Ryabchenko, MD, PhD, Head of Surgery Department
6/2, Redpartizan St., 350012, Krasnodar
References
1. Rhatigan R.M., Roque J.L., Bucher R.L. Mucoepidermoid carcinoma of the thyroid gland. Cancer. 1977; 39(1): 210–4. doi: 10.1002/1097-0142-(197701)39:1<210::aid-cncr2820390133>3.0.co;2-h.
2. Sim S.J., Ro J.Y., Ordonez N.G., Cleary K.R., Ayala A.G. Sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid: report of two patients, one with distant metastasis, and review of the literature. Hum Pathol. 1997; 28(9): 1091–6. doi: 10.1016/s0046-8177(97)90064-2.
3. Chan J.K., Albores-Saavedra J., Battifora H., Carcangiu M.L., Rosai J. Sclerosing mucoepidermoid thyroid carcinoma with eosinophilia. A distinctive low-grade malignancy arising from the metaplastic follicles of Hashimoto’s thyroiditis. Am J Surg Pathol. 1991; 15(5): 438–48.
4. Hunt J.L., LiVolsi V.A., Barnes E.L. p63 expression in sclerosing mucoepidermoid carcinomas with eosinophilia arising in the thyroid. Mod Pathol 2004; 17: 526–9. doi: 10.1038/modpathol.3800021.
5. Lai C.Y., Chao T.C., Lin J.D., Hsueh C. Sclerosing mucoepidermoid carcinoma with eosinophilia of thyroid gland in a male patient: a case report and literature review. Int J Clin Exp Pathol. 2015; 8(5): 5947–51.
6. Requena M., Percovich J.C., Sambo M.E., Andía V.M. Conservative Management of Sclerosing Mucoepidermoid Carcinoma with Eosinophilia of the Thyroid Gland: 12 Years Follow-Up after an Atypical Initial Therapy. Adv Diabetes Endocrinol 2017; 2(1): 2.
7. Pantola C., Kala S., Athar M., Thakur S. Sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid: A cytological dilemma. J Cytol. 2016; 33(1): 37–9. doi: 10.4103/0970-9371.175511.
8. Ames E., Campbell M.J., Affy A., Krane J.F., Huang E.C. Sclerosing mucoepidermoid carcinoma with eosinophilia: Cytologic characterization of a rare distinct entity in the thyroid. Diagn Cytopathol. 2018; 46(7): 632–5. doi: 10.1002/dc.23914.
9. Shehadeh N.J., Vernick J., Lonardo F., Madan Sh.K., Jacobs J.R., Yoo G.H., Kim H.E., Ensley J.F. Sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid: a case report and review of the literature. Am J Otolaryngol 2004; 25(1): 48–53. doi: 10.1016/S0196-0709-(03)00096-6.
10. Sang-wook Son, Kye-ho Lee, Jai Hyuen Lee, Na-Hye Myong, Dong-soo Yoo. Mucoepidermoid Carcinoma with Distant Metastases to the Kidney, Adrenal Gland, Skull and Gluteus Maximus Muscle: a Case Report. Investig Magn Reson Imaging. 2016; 20(1): 66–70. doi: 10.13104/imri.2016.20.1.66.
11. Toper M.H., Sarioglu S. Molecular Pathology of Salivary Gland Neoplasms: Diagnostic, Prognostic, and Predictive Perspective. Adv Anat Pathol. 2021; 28(2): 81–93. doi: 10.1097/PAP.0000000000000291.
12. Healey W.V., Perzin K.H., Smith L. Mucoepidermoid carcinoma of salivary gland origin. Classifcation, clinical-pathologic correlation, and results of treatment. Cancer. 1970; 26(2): 368–88. doi: 10.1002/1097-0142(197008)26:2<368::aid-cncr2820260219>3.0.co;2-k.
13. Shafque K., Zhang P.J., Montone K.T., Song S., Livolsi V.A., Baloch Z. Pathologic grading of mucoepidermoid carcinomas of the salivary gland and its effect on clinicopathologic follow-up: an institutional experience. Hum Pathol. 2020; 98: 89–97. doi: 10.1016/j.humpath.2020.02.001.
14. Hong D.S., Fakih M.G., Strickler J.H., Desai J., Durm G.A., Shapiro G.I., Falchook G.S., Price T.J., Sacher A., Denlinger C.S., Bang Y.J., Dy G.K., Krauss J.C., Kuboki Y., Kuo J.C., Coveler A.L., Park K., Kim T.W., Barlesi F., Munster P.N., Ramalingam S.S., Burns T.F., Meric-Bernstam F., Henary H., Ngang J., Ngarmchamnanrith G., Kim J., Houk B.E., Canon J., Lipford J.R., Friberg G., Lito P., Govindan R., Li B.T. KRASG12C Inhibition with Sotorasib in Advanced Solid Tumors. N Engl J Med. 2020; 383(13): 1207–17. doi: 10.1056/NEJMoa1917239.
15. Loong H.H., Du N., Cheng C., Lin H., Guo J., Lin G., Li M., Jiang T., Shi Z., Cui Y., Jin X., Yao J., Xing Y., Yao M., Wang K., Mok T.S.K., Liu L. KRAS G12C mutations in Asia: a landscape analysis of 11,951 Chinese tumor samples. Transl Lung Cancer Res. 2020; 9(5): 1759–69. doi: 10.21037/tlcr-20-455.
Review
For citations:
Ryabchenko E.V. Sclerosing mucoepidermoid thyroid carcinoma combined with autoimmune thyroiditis. Siberian journal of oncology. 2023;22(4):154-158. (In Russ.) https://doi.org/10.21294/1814-4861-2023-22-4-154-158
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