Preview

Siberian journal of oncology

Advanced search

OPTIMIZATION OF THE CHOICE OF ADJUVANT THERAPY IN PATIENTS WITH UTERINE CORPUS CANCER

Abstract

Despite the large number of studies, including randomized, the role of adjuvant radiotherapy for early-stage uterine corpus cancer remains a matter of debate. We present our results and literature review devoted to the analysis of the effectiveness of new prognostic criteria for cancer of the corpus uteri. The introduction of these markers into routine clinical practice will allow a personalized treatment for patients with stage I uterine corpus cancer.

About the Authors

А. L. Chernyshova
Tomsk Cancer Research Institute National Research Tomsk Polytechnic University, Tomsk
Russian Federation
5, Kooperativny Street, 634050-Tomsk


Zh. А. Startseva
Tomsk Cancer Research Institute National Research Tomsk Polytechnic University, Tomsk
Russian Federation
5, Kooperativny Street, 634050-Tomsk


А. А. Zatolokina
Tomsk Cancer Research Institute
Russian Federation


References

1. Bochkareva N.V., Kondakova I.V., Kolomiec L.A., Chernyshova A.L. Insulin-like growth factors and insulin-like growth factor binding proteins in pathogenesis of endometrial cancer // Sibirskij onkologicheskij zhurnal. 2008. № 3. P. 86–93. [in Russian]

2. Zhogina Zh.A., Musabaeva L.I., Slonimskaja E.M. Indications for the choice of adjuvant radiotherapy extent for patients with breast cancer after radical mastectomy // Sibirskij onkologicheskij zhurnal. 2005. № 3. P. 3–10. [in Russian]

3. Krikunova L.I. Radiation therapy for uterine cancer // Prakticheskaja onkologija. 2004. Vol. 5 (1). P. 33–40. [in Russian]

4. Nechushkina V.M., Morhov K.Ju., Kuznecov V.V. Adjuvant therapy for early-stage endometrial cancer // Vestnik RONC im. N.N. Blohina RAMN. 2012. Vol. 23 (4). P. 33–40. [in Russian]

5. Spirina L.V., Bochkareva N.V., Kondakova I.V., Kolomiec L.A., Shashova E.E., Koval’ V.D., Chernyshova A.L., Asadchikova O.N. Regulation of insulin-like growth factors and NF-κ by proteasome system in endometrial cancer // Molekuljarnaja biologija. 2012. Vol. 46 (3). P. 452–460. [in Russian]

6. Spirina L.V., Kondakova I.V., Usynin E.A., Kolomiec L.A., Vintizenko S.I., Bochkareva N.V., Chernyshova A.L. Proteasome activity and growth factor expression in bladder, kidney and endometrial cancers // Rossijskij onkologicheskij zhurnal. 2010. № 1. P. 23–25 [in Russian]

7. Musabaeva L.I., Garbukov E.Ju., Usova A.V., Frolova I.G., Starceva Zh.A., Velikaja V.V., Kucherova T.Ja. Acute Radiation Reaction in Breast Cancer Patients Treated with Organ-Preserving Surgery, Intraoperative Electron Beam Therapy and External Beam Radiation Therapy // Medicinskaja radiologija i radiacionnaja bezopasnost’. 2012. Vol. 57 (2). P. 78–82. [in Russian]

8. Chernyshova A.L., Kolomiec L.A., Bochkareva N.V., Asadchikova O.N. Metabolic syndrome, interraction with endometrial carcinogenesis // Sibirskij onkologicheskij zhurnal. 2008. № 5. P. 68–74. [in Russian]

9. Chernyshova A.L., Kolomiec L.A., Krickaja N.G., Suhodolo I.V. Prognostic criteria of cancer risk in proliferative diseases of the endometrium // Rossijskij onkologicheskij zhurnal. 2005. № 3. P. 22–25. [in Russian]

10. Chojnzonov E.L., Pisareva L.F., Cherdynceva N.V., Bojarkina A.P., Odincova I.N., Martynova N.A. Cancer incidence in Siberia and Russian Far East. Cancer care service and ways of its improvement // Bjulleten’ Sibirskogo otdelenija Rossijskoj akademii medicinskih nauk. 2004. № 2. P. 41–47. [in Russian]

11. Chojnzonov E.L., Pisareva L.F., Zhujkova L.D. Cancer incidence in the Tomsk region during the period 2004–2009. Assessment of diagnostic quality // Sibirskij onkologicheskij zhurnal. 2011. № 3. P. 29–34. [in Russian]

12. ASTEC/EN.5 Study Group, Blake P., Swart A.M., Orton J., Kitchener H., Whelan T., Lukka H., Eisenhauer E., Bacon M., Tu D., Parmar M.K., Amos C., Murray C., Qian W. Adjuvant external beam radiotherapy in the treatment of endometrial cancer (MRCASTEC and NCIC CTG EN.5 randomised trials): pooled trial results, systematic review, and meta-analysis // Lancet. 2009. Vol. 373 (9658). P. 137–146. doi: 10.1016/ S0140-6736(08)61767-5.

13. Creasman W.T., Odicino F., Maisonneuve P., Quinn M.A., Beller U., Benedet J.L., Heintz A.P., Ngan H.Y., Pecorelli S. Carcinoma of the Corpus Uteri FIGO 26th Annual Report on the Results of Treatment in Gynecological Cancer // Int. J. Gynaecol. Obstet. 2006. Vol. 95. Suppl. 1. S. 105–144.

14. Johnson N., Cornes P. Survival and recurrent disease after postoperative radiotherapy for early endometrial cancer: systematic review and meta-analysis // BJOG. 2007. Vol. 114 (11). P. 1313–1320.

15. Keys H.M., Roberts J.A., Brunetto V.L., Zaino R.J., Spirtos N.M., Bloss J.D., Pearlman A., Maiman M.A., Bell J.G. A phase III trial of surgery with or without adjunctive external pelvic radiation therapy in intermediate risk endometrial adenocarcinoma: a Gynecologic Oncology Group study // Gynecol. Oncol. 2004. Vol. 92 (3). P. 744–751.

16. Lindemann K., Onsrud M., Tropé C.G., Kristensen G.B. Long-term survival after radiation therapy for early stage endometrial carcinoma: the Oslo study revisited // Int. J. Gynecol. Cancer. 2012. Vol. 22 (8). Suppl. 3. E. 111.

17. NCCN Clinical Practice Guidelines In Oncology Uterine Neoplasms. Version 3.2012 [Электронный ресурс] URL: http://www.nccn.org/ professionals/physician_gls/pdf/uterine.pdf (дата обращения: 01.10.12).

18. Nout R.A., Smit V., Putter H., Jürgenliemk-Schulz I.M., Jobsen J.J., Lutgens L.C., van der Steen-Banasik E.M., Mens J.W., Slot A., Kroese M.C., van Bunningen B.N., Ansink A.C., van Putten W.L., Creutzberg C.L. Vaginal brachytherapy versus pelvic external beam radiotherapy for patients with endometrial cancer of high-intermediate risk (PORTEC-2): an open-label, non-inferiority, randomised trial // Lancet. 2010. Vol. 375 (9717). P. 816–823. doi: 10.1016/S0140-6736(09)62163-2.

19. Spirina L.V., Yunusova N.V., Kondakova I.V., Koval V.D., Chernyshova A.L., Scpileva O.V. Assotiation of growth factors, HIF-1 and NF-kB expression with proteasomes in endometrial cancer // Mol. Biol. Rep. 2012. C. 8655-8662. doi: 10.1007/s11033-012-1720-y.

20. Straughn J.M., Huh W.K., Orr J.W. Jr., Kelly F.J., Roland P.Y., Gold M.A., Powell M., Mutch D.G., Partridge E.E., Kilgore L.C., Barnes M.N., Austin J.M. Jr., Alvarez R.D. Stage IC adenocarcinoma of the endometrium: survival comparisons of surgically staged patients with and without adjuvant radiation therapy // Gynecol. Oncol. 2003. Vol. 89 (2). P. 295–300.


Review

For citations:


Chernyshova А.L., Startseva Zh.А., Zatolokina А.А. OPTIMIZATION OF THE CHOICE OF ADJUVANT THERAPY IN PATIENTS WITH UTERINE CORPUS CANCER. Siberian journal of oncology. 2014;(6):54-59. (In Russ.)

Views: 575


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1814-4861 (Print)
ISSN 2312-3168 (Online)