TREATMENT OUTCOMES IN PATIENTS WITH PELVIC CHONDROSARCOMA
https://doi.org/10.21294/1814-4861-2016-15-2-21-28
Abstract
The purpose of the study: to evaluate the efficacy of surgical and combined modality treatment in patients with pelvic chondrosarcoma. Materials and methods. The study included 52 patients with pelvic chondrosarcoma. Forty-two (81 %) patients had well-differentiated and 10 (19 %) patients had poorly differentiated chondrosarcoma. Sixteen (30 %) patients underwent interiliac-abdominal resection of the pelvis and 36 (70 %) patients were treated with organ-preserving surgery. Of the patients treated with organpreserving surgery, 22 (61 %) patients underwent reconstructive surgery. The follow-up period was 45 months (range, 8 –18 months). Results. Positive resection margins were found in 8 (15 %) patients. Postoperative complications were observed in 13 (25 %) patients. The median MSTS score was 92 % (range, 62–100%) for 14 (27 %) patients, who underwent surgery without reconstruction and 67 % (range, 40–95 %) for 22 (61 %) patients, who underwent reconstructive surgery. For 16 (30 %) patients, who underwent interiliacabdominal resection of the pelvis, the median MSTS score was 45 % (range, 25–68 %). Disease progression was observed in 16 (31 %) patients. The overall 5-year survival rate was 75 % and the 5-yaer disease-free survival rate was 60 %. Conclusion. The oncology and functional outcomes are consistent with other recent studies, which indicate that organ-preserving surgery may be an appropriate approach in the treatment of patients with pelvic chondrosarcoma.
About the Authors
V. А. Derzhavin
P.A. Hertsen Moscow Research Institute of Oncology, 3, 2-nd Botkinsky proezd, 125284, Moscow
Russian Federation
Russian Federation
MD, PhD, Scientific Associate, Department of Surgical Treatment for Tumors of the Central Nervous and Musculoskeletal System, P.A. Gertsen Moscow Research Institute of Oncology (Moscow). Russia. SPIN-code: 1811-2737.
А. V. Bukharov
P.A. Hertsen Moscow Research Institute of Oncology, 3, 2-nd Botkinsky proezd, 125284, Moscow
Russian Federation
Russian Federation
MD, PhD, Senior Researcher, of the Group of Bone and Soft Tissue Tumors, Department of Surgical Treatment for Tumors of the Central Nervous and Musculoskeletal System, P.A. Gertsen Moscow Research Institute of Oncology (Moscow). Russia. SPIN-code: 8349-0930.
V. Yu. Karpenko
P.A. Hertsen Moscow Research Institute of Oncology, 3, 2-nd Botkinsky proezd, 125284, Moscow
Russian Federation
Russian Federation
MD, PhD, Head of the Group of Bone and Soft Tissue Tumors, Department of Surgical Treatment for Tumors of the Central Nervous and Musculoskeletal System, P.A. Gertsen Moscow Research Institute of Oncology (Moscow). Russia. SPIN-code: 1360-8298
А. V. Yadrina
I.M. Sechenov Moscow State Medical University, Moscow
Russian Federation
Russian Federation
Intern, Department of Oncology, P.A. Gertsen Moscow Research Institute of Oncology (Moscow). Russia.
М. S. Andreev
I.M. Sechenov Moscow State Medical University, Moscow
Russian Federation
Russian Federation
Postgraduate student, Department of Oncology and Radiotherapy, N.M. Sechenov «First Moscow State Medical University» (Moscow). Russia.
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Review
For citations:
Derzhavin V.А., Bukharov А.V., Karpenko V.Yu., Yadrina А.V., Andreev М.S. TREATMENT OUTCOMES IN PATIENTS WITH PELVIC CHONDROSARCOMA. Siberian journal of oncology. 2016;15(2):21-28. (In Russ.) https://doi.org/10.21294/1814-4861-2016-15-2-21-28
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