SIGNIFICANCE OF PROGNOSTIC FACTORS IN THE MULTIMODALITY TREATMENT OF SUPRATENTORIAL INFILTRATIVE LOW-GRADE GLIOMAS
https://doi.org/10.21294/1814-4861-2016-15-3-56-61
Abstract
Background. Objectives: analysis of the most important prognostic factors for progression-free survival (PFS) in patients with low-grade cerebral gliomas (LGG). material and methods. 107 patients with morphologically proven low-grade cerebral gliomas were included into the study. There were 57 (53.3 %) patients with diffuse astrocytoma, 14 (13.1 %) with oligoastrocytoma and 36 (33.6 %) patients with oligodendroglioma. Results. Risk factors included age ≥40 years, diffuse astrocytoma, tumor size of more than 6 cm, displacement of the midbrain structures and severe or moderate neurological deficit. Acute cerebral circulatory disorder and the extent of surgical excision of the tumor did not effect on the outcome of LGG treatment. The highest rates of PFS were observed in patients with stage T3 disease and the lowest PFS rates in patients with stage III disease. Conclusion. Significant risk factors should be considered in planning multi-modality treatment for low grade cerebral gliomas.
About the Authors
V. A. Solodkiy
Russian Scientific Center of Roentgenoradiology of Russia, Moscow
Russian Federation
MD, DSc, Corresponding Member
Russian Federation
MD, DSc, Corresponding Member
S. M. Milyukov
Peoples’ Friendship University of Russia, Moscow
Russian Federation
Postgraduate student, Department of oncology and roentgenoradiology
Russian Federation
Postgraduate student, Department of oncology and roentgenoradiology
N. V. Kharchenko
Peoples’ Friendship University of Russia, Moscow
Russian Federation
MD, DSc, Professor, Head of the Department of oncology and roentgenoradiology
Russian Federation
MD, DSc, Professor, Head of the Department of oncology and roentgenoradiology
T. R. Izmailov
Russian Scientific Center of Roentgenoradiology of Russia, Moscow
Russian Federation
MD, PhD, Radiation oncologist
Russian Federation
MD, PhD, Radiation oncologist
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Review
For citations:
Solodkiy V.A., Milyukov S.M., Kharchenko N.V., Izmailov T.R. SIGNIFICANCE OF PROGNOSTIC FACTORS IN THE MULTIMODALITY TREATMENT OF SUPRATENTORIAL INFILTRATIVE LOW-GRADE GLIOMAS. Siberian journal of oncology. 2016;15(3):56-61. (In Russ.) https://doi.org/10.21294/1814-4861-2016-15-3-56-61
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