Synchronous multiple primary colorectal cancer in patients with extraintestinal malignancies
https://doi.org/10.21294/1814-4861-2025-24-2-101-107
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Abstract
Introduction. The incidence of colorectal cancer (CRC) is steadily increasing in Russia. Patients with cancers of extra-intestinal malignancies are at increased risk of developing CRC. However, currently, there is no a science-based screening system for synchronous primary-multiple CRC among this group of patients. The aim of the study was to analyze features of synchronous CRC among patients with extra-intestinal malignancies. Material and Methods. The medical records of 53 cancer patients registered at the Kursk Oncology Research and Clinical Center named after G.E. Ostroverkhov were analyzed. The inclusion criteria were: the presence of histologically verified newly diagnosed cancer of extra-intestinal location, detection and histological verification of CRC between 2018 and 2022, and the interval between the detection of malignancies of more than 6 months. The decision to conduct an additional examination was made on the basis of complaints of the patients, medical history, physical examination and diagnostic imaging findings. The decision of complex examination was based on complaints, anamnesis and physical data. Results. Among patients with synchronous multiple primary CRC, there were more men (60.4 %) than women. The median age of the patients was 67 years. The risk group for synchronous multiple primary CRC included patients with urological, gynecological, skin, gastric, breast and lung cancers. Examination of the colon in patients with urological, gynecological, skin, gastric and lung cancers (p <0.05) resulted in the detection of synchronous stage I CRC in the distal colon within a month after histologically verified extra-intestinal malignancies in 50.9 % of cases (p<0.05). Conclusion. We recommend the following examination protocol: all primary patients with urological, gynecological, skin, gastric and lung cancers should undergo animmunochemical quantitative fecal occult blood tests no later than 7 days after verification of an extra-intestinal cancer. Such strategy will allow timely detection of multiple primary synchronous CRC.
About the Authors
V. V. PodolskiyRussian Federation
Vladimir V. Podolskiy, MD, Endoscopist
1, Eliseeva St., Kislino village, Kursk region, 305524
E. A. Podolskaya
Russian Federation
Elena A. Podolskaya, MD, DSc, Assistant, Department of Radiation Diagnostics and Therapy
3, K. Marx St., Kursk, 305041
References
1. Fukatsu H., Kato J., Nasu J.I., Kawamoto H., Okada H., Yamamoto H., Sakaguchi K., Shiratori Y. Clinical characteristics of synchronous colorectal cancer are different according to tumour location. Dig Liver Dis. 2007; 39(1): 40-46. https://doi.org/10.1016/j.dld.2006.07.015.
2. Mulder S.A., Kranse R., Damhuis R.A., de Wilt J.H., Ouwendijk R.J., Kuipers E.J., van Leerdam M.E. Prevalence and prognosis of synchronous colorectal cancer: a Dutch population-based study. Cancer Epidemiol. 2011; 35(5): 442-47. https://doi.org/10.1016/j.canep.2010.12.007.
3. Ławniczak M., Gawin A., Jaroszewicz-Heigelmann H., RogozaMateja W., Raszeja-Wyszomirska J., Białek A., Karpińska-Kaczmarczyk K., Starzyńska T. Synchronous and metachronous neoplasms in gastric cancer patients: a 23-year study. World J Gastroenterol. 2014; 20(23): 7480-87. https://doi.org/10.3748/wjg.v20.i23.7480.
4. Vogt A., Schmid S., Heinimann K., Frick H., Herrmann C., Cerny T., Omlin A. Multiple primary tumours: challenges and approaches, a review. ESMO Open. 2017; 2(2). https://doi.org/10.1136/esmoopen-2017-000172.
5. Cancer care for the population of Russia in 2022. Ed. by A.D. Kaprin, V.V. Starinsky, A.O. Shakhzadova. Moscow, 2023. 251 p. (in Russian). ISBN: 978-5-85502-283-4.
6. Colon cancer: slinical recommendations of the Ministry of Health of the Russian Federation. 2022. (in Russian). [Internet]. [cited 11.04.2025]. URL: https://cr.minzdrav.gov.ru/preview-cr/396_3.
7. Rectal cancer: Clinical recommendations of the Ministry of Health of the Russian Federation. 2022. (in Russian). [Internet]. [cited 11.04.2025]. URL: https://cr.minzdrav.gov.ru/preview-cr/554_3.
8. Soldatkina N.V., Kit O.I., Gevorkyan Yu.A., Milakin A.G. Multiple primary colorectal cancer: clinical aspects. Therapeutic Archive. 2016; 88(8): 53-58. (in Russian). https://doi.org/10.17116/terarkh201688853-58. EDN: WKGCEF.
9. Krylov N. Primary multiple synchronous colon cancer (trends in diagnosis and treatment). Doctor. 2015; 5: 6-9. (in Russian). EDN: TWMVHX.
10. Popova T.N. About primary multiple synchronous malignant neoplasms. East European Scientific Journal. 2018; 4(32): 18-24. (in Russian).
11. On approval of the Procedure for the provision of medical care to the adult population for cancer (as amended and supplemented): Order of the Ministry of Health of the Russian Federation of February 19, 2021. No. 116n. (in Russian). [Internet]. [cited 11.04.2025]. URL: https://normativ.kontur.ru/document?moduleId=1&documentId=419184.
12. On the organization of medical care in the oncology profile in the Kursk region: Order of the Health Committee of the Kursk Region dated 12.05.2022. No. 320 (in Russian). [Internet]. [cited 11.04.2025]. URL: https://onco46.ru/upload/sprint.editor/901/8jtjjd2m5nk1r6zteblbuqcx2k7emelq.pdf.
13. Nasledov A.D. IBM SPSS Statistics 20 and AMOS, Professional Statistical Data Analysis. M., 2013. (in Russian).
14. Semionkin E.I., Lukanin R.V., Bragina I.Yu., Snegur S.V., Yudina E.A., Krotkov A.R. Primary multiple bowel cancer. Bulletin of the National Medical and Surgical Center named after N.I. Pirogov. 2023; 18(2): 139-42. (in Russian). https://doi.org/10.25881/20728255_2023_18_2_139. EDN: DKDCZY.
15. On approval of the procedure for conducting preventive medical examination and clinical examination of certain groups of the adult population. (As amended on July 19, 2024). Order of the Ministry of Health of the Russian Federation of April 27, 2021 No. 404n. (in Russian). [Internet]. [cited 11.04.2025]. URL: https://docs.cntd.ru/document/607124051.
16. Bakulin I.G., Zharkov A.V., Zhuravleva M.S., Serkova M.Yu. Colorectal cancer screening: current status and future prospects. Preventive Medicine. 2023; 26(12): 12-18. (in Russian). https://doi.org/10.17116/profmed20232612112. EDN: CKWLNQ.
Review
For citations:
Podolskiy V.V., Podolskaya E.A. Synchronous multiple primary colorectal cancer in patients with extraintestinal malignancies. Siberian journal of oncology. 2025;24(2):101-107. (In Russ.) https://doi.org/10.21294/1814-4861-2025-24-2-101-107
ISSN 2312-3168 (Online)