NEOADJUVANT CHEMOTHERAPY WITH RADICAL CYSTECTOMY IN THE TREATMENT OF MUSCLE-INVASIVE BLADDER CANCER
https://doi.org/10.21294/1814-4861-2016-15-4-45-49
Abstract
The results of the combined treatment of 36 patients with muscle-invasive bladder cancer treated with neoadjuvant combination chemotherapy with Gemzar + Cisplatin. The control group included 167 patients who underwent surgical treatment. In multivariate statistical analysis found that the use neoadjuvant combination chemotherapy significantly improves long-term results of treatment at a moderate degree of tumor differentiation (G2), bladder cancer II stage, in the absence of lymph node involvement (N0) and in patients younger than 65 years.
About the Authors
N. S. NurgalievKazakhstan
Nurglaliev Nurzhan S., MD, PhD, Head of Oncourological Center
. SPIN-code: 6171-7346
Zh. A. Arzykulov
Kazakhstan
Arzykulov Zh. A., MD, DSc, Chief of National Surgery Science Center named after A.N. Syzganov
E. I. shkinin
Kazakhstan
Ishkinin E.I., Radiologist, Oncourological Center
References
1. Ferlay J., Soerjomataram I., Ervik M., Dikshit R., Eser S., Mathers C., Rebelo M., Parkin D.M., Forman D., Bray F. GLOBOCAN 2012 v1.1, Cancer Incidence and Mortality Worldwide: IARC Cancer Base No. 11 [Internet]. Lyon, France: International Agency for Research on Cancer; 2014. Available from: http://globocan.iarc.fr, accessed on 08/09/2015.
2. Apolo A.B., Kim J.W., Bochner B.H., Steinberg S.M., Bajorin D.F., Kelly W.K., Agarwal P.K., Koppie T.M., Kaag M.G., Quinn D.I., Vogelzang N.J., Sridhar S.S. Examining the management of muscle-invasive bladder cancer by medical oncologists in the United States. Urol Oncol. 2014 Jul; 32 (5): 637–44. doi: 10.1016/j.urolonc.2013.12.012.
3. Cowan N.G., Chen Y., Downs T.M., Bochner B.H., Apolo A.B., Porter M.P., La Rochelle J.C., Amling C.L., Koppie T.M. Neoadjuvant chemotherapy use in bladder cancer: a survey of current practice and opinions. Adv Urol. 2014; 2014: 746298. doi: 10.1155/2014/746298.
4. El-Gehani F., North S., Ghosh S., Venner P. Improving the outcome of patients with muscle invasive urothelial carcinoma of the bladder with neoadjuvant gemcitabine/cisplatin chemotherapy: A single institution experience. Can Urol Assoc J. 2014 Mar; 8 (3–4): e287–93. doi: 10.5489/cuaj.1643.
5. Khaled H.M., Shafik H.E., Zabhloul M.S., Ghoneim M., Saber R.A., Manie M., Enein H.A., Megeed H.A., Mansur O., Sherbini M.E., Mahran T.Z., Kalawee M.E., Badran A., Ramadan S.M. Gemcitabine and Cisplatin as Neoadjuvant Chemotherapy for Invasive Transitional and Squamous Cell Carcinoma of the Bladder: Effect on Survival and Bladder Preservation. Clin Genitourin Cancer. 2014 Oct; 12 (5): e233–40. doi: 10.1016/j.clgc.2014.04.002.
6. von der Maase H., Hansen S., Roberts J.T., Dogliotti L., Oliver T., Moore M.J., Bodrogi I., Albers P., Knuth A., Lippert C.M., Kerbrat P., Sanchez Rovira P., Wersall P., Cleall S.P., Roychowdhury D.F., Tomlin I., Visseren-Grul C.M., Conte P.F. Gemcitabine and cisplatin versus methotrexate, vinblastine, doxorubicin, and cisplatin in advanced or metastatic bladder cancer: results of a large, randomized, multinational, multicenter, phase III study. J Clin Oncol. 2000 Sep; 18 (17): 3068–77.
7. Sakatani T., Shimizu Y., Sugino Y., Yamasaki T, Imamura M., Matsui Y., Inoue T., Okubo K., Kamba T., Yoshimura K., Ogawa O. Small cell carcinoma of the bladder. Hinyokika Kiyo. 2014 May; 60 (5): 221–5.
8. Grossman H.B., Natale R.B., Tangen C.M., Speights V.O., Vogelzang N.J., Trump D.L., deVere White R.W., Sarosdy M.F., Wood D.P. Jr., Raghavan D., Crawford E.D. Neoadjuvant chemotherapy plus cystectomy compared with cystectomy alone for locally advanced bladder cancer. N Engl J Med. 2003 Aug 28; 349 (9): 859–66.
9. Shelley M., Cleves A., Wilt T.J., Mason M. Gemcitabine for unresectable, locally advanced or metastatic bladder cancer. Cochrane Database Syst Rev. 2011 Apr 13; (4): CD008976. doi: 10.1002/14651858. CD008976.pub2.
Review
For citations:
Nurgaliev N.S., Arzykulov Zh.A., shkinin E.I. NEOADJUVANT CHEMOTHERAPY WITH RADICAL CYSTECTOMY IN THE TREATMENT OF MUSCLE-INVASIVE BLADDER CANCER. Siberian journal of oncology. 2016;15(4):45-49. (In Russ.) https://doi.org/10.21294/1814-4861-2016-15-4-45-49