HETEROGENENOUS EXPRESSION OF MARKERS ASSOCIATED WITN INVASIVE BREAST CANCER
https://doi.org/10.21294/1814-4861-2016-15-4-56-61
Abstract
The paper is devoted to the study of the expression of markers associated with invasive breast carcinoma. The study included a surgical material from 107 patients with invasive carcinoma of the non-specific type of breast cancer who had not previously received neoadjuvant therapy. The study revealed a number of markers related to invasive tumor growth, characterized by a pronounced heterogeneous expression pattern in all cases. Study of the expression of markers associated with invasive breast carcinoma showed that not all cells are able to promote invasive growth in different periods of time, but the fact of detecting the positive expression of the markers in tissue tumors indicates a more aggressive cancer phenotype with a high potential for invasion.
About the Authors
N. V. Krakhmal
Siberian State Medical University, Tomsk
Russian Federation
Russian Federation
Krakhmal Nadezhda V., Postgraduate, Pathologic Anatomy Department
SPIN-code: 1543-6546
M. V. Zavyalova
Siberian State Medical University, Tomsk;
Tomsk Cancer Research Institute, Tomsk;
Tomsk State University, Tomsk
Russian Federation
Russian Federation
Zavyalova Marina V., MD, DSc, Professor, Senior Researcher of the Department of Pathological Anatomy and Cytology of Tomsk Cancer Research Institute; Head of Pathological Anatomy Department of Siberian State Medical University
SPIN-code: 1229-0323
V. M. Perelmuter
Siberian State Medical University, Tomsk;
Tomsk Cancer Research Institute, Tomsk
Russian Federation
Russian Federation
Perelmuter Vladimir M., MD, DSc, Professor of Department of Pathological Anatomy of Siberian State Medical University, Head of Department of Pathological Anatomy and Cytology, Tomsk Cancer Research Institute
SPIN-код: 6252-5319
S. V. Vtorushin
Siberian State Medical University, Tomsk;
Tomsk Cancer Research Institute, Tomsk
Russian Federation
Russian Federation
Vtorushin Sergey V., MD, DSc, Professor of Pathological Anatomy Department of Siberian State Medical University; Senior Researcher of the Department of Pathologic Anatomy and Cytology of Tomsk Cancer Research Institute
SPIN-код: 2442-4720
E. M. Slonimskaya
Siberian State Medical University, Tomsk;
Tomsk Cancer Research Institute, Tomsk
Russian Federation
Russian Federation
Slonimskaya Elena M., MD, Professor, of Department of Oncologyi of Siberian State Medical University; Head of General Oncology Department, Tomsk Cancer Research Institute
SPIN-code: 7763-6417
E. V. Denisov
Tomsk Cancer Research Institute, Tomsk;
Tomsk State University, Tomsk
Russian Federation
Russian Federation
Denisov Evgeny V., PhD, Senior Researcher, Laboratory of Molecular Oncology and Immunology, Tomsk Cancer Research Institute
SPIN-code: 9498-5797
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Review
For citations:
Krakhmal N.V., Zavyalova M.V., Perelmuter V.M., Vtorushin S.V., Slonimskaya E.M., Denisov E.V. HETEROGENENOUS EXPRESSION OF MARKERS ASSOCIATED WITN INVASIVE BREAST CANCER. Siberian journal of oncology. 2016;15(4):56-61. (In Russ.) https://doi.org/10.21294/1814-4861-2016-15-4-56-61
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