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Adenomyoepithelioma of the breast: a case report

https://doi.org/10.21294/1814-4861-2025-24-6-173-182

Abstract

Background. Adenomyoepithelioma of the breast is a rare benign tumor characterized by biphasic proliferation of epithelial and myoepithelial cells of the lobular and ductal components of the breast. Although benign, adenomyoepithelioma has a potential for malignant transformation; therefore its early detection is crucial. Currently, there are no established clinical, radiological and morphological criteria for early detection of this type of tumor, which can complicate diagnosis and requires histological examination of the tumor. description of the clinical case. A 39-year-old female patient presented to the Oncology Center No. 1 of the S.S. Yudin Clinical Hospital with the breast neoplasm detected during a routine examination. Ultrasound examination showed fibroadenoma. Histological examination of the trepan biopsy specimen revealed adenomyoepithelioma. The patient underwent a sectoral resection of the right breast. Histology and immunohistochemistry confirmed the diagnosis of adenomyoepithelioma.

Conclusion. Breast adenomyoepithelioma is a rare tumor diagnosed by histology/immunohistochemistry, with surgery as a main treatment. Further research is needed to study the pathogenesis.

About the Authors

T. S. Berestok
S.S. Yudin City Clinical Hospital, Moscow Department of Health
Russian Federation

Tatiana S. Berestok - MD, PhD, Oncologist, Oncology Center No. 1.

18A, Zagorodnoe shosse, Moscow, 117152



M. S. Ermoshchenkova
S.S. Yudin City Clinical Hospital, Moscow Department of Health; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia
Russian Federation

Maria V. Ermoshchenkova - MD, DSc, Head of the First Oncology Surgery Department, Oncology Center No. 1, S. S. Yudin CCH, Moscow Department of Health; Professor, Department of Oncology, Radiotherapy and Reconstructive Surgery, N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow SMU.

18A, Zagorodnoe shosse, Moscow, 117152; 8-2, Trubetskaya St., Moscow, 119992



V. N. Galkin
S.S. Yudin City Clinical Hospital, Moscow Department of Health; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia
Russian Federation

Vsevolod N. Galkin - MD, DSc, Chief Physician, S. S. Yudin CCH, Moscow Department of Health; Professor, Department of Oncology, Radiotherapy and Reconstructive Surgery, N.V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow SMU.

18A, Zagorodnoe shosse, Moscow, 117152; 8-2, Trubetskaya St., Moscow, 119992



A. B. Semenova
S.S. Yudin City Clinical Hospital, Moscow Department of Health
Russian Federation

Anna B. Semenova - MD, DSc, Head of the Center for Pathoanatomic Diagnostics and Molecular Genetics, Oncology Center No. 1.

18A, Zagorodnoe shosse, Moscow, 117152



V. V. Didenko
S.S. Yudin City Clinical Hospital, Moscow Department of Health
Russian Federation

Vera V. Didenko - MD, Head of the Department of Diagnosis and Treatment of Diseases of the Breast and Reproductive System, Oncology Center No. 1.

18A, Zagorodnoe shosse, Moscow, 117152



V. G. Shatalov
S.S. Yudin City Clinical Hospital, Moscow Department of Health
Russian Federation

Vitaly G. Shatalov - MD, Head of the Pathology Department, Oncology Center No. 1.

18A, Zagorodnoe shosse, Moscow, 117152



O. I. Isaeva
S.S. Yudin City Clinical Hospital, Moscow Department of Health
Russian Federation

Oxana I. Isaeva - MD, Pathologist, Oncology Center No. 1.

18A, Zagorodnoe shosse, Moscow, 117152



M. A. Bogatyreva
S.S. Yudin City Clinical Hospital, Moscow Department of Health
Russian Federation

Marina A. Bogatyreva - MD, Pathologist, Oncology Center No. 1.

18A, Zagorodnoe shosse, Moscow, 117152



O. I. Startsevа
S.S. Yudin City Clinical Hospital, Moscow Department of Health; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia
Russian Federation

Olesya I. Startseva - MD, DSc, Professor, Department of Oncology, Radiotherapy and Reconstructive Surgery, I.M. Sechenov First Moscow SMU; Oncologist, Oncology Department No. 1, Oncology Center No. 1, S. S. Yudin CCH, Moscow Department of Health.

18A, Zagorodnoe shosse, Moscow, 117152; 8-2, Trubetskaya St., Moscow, 119992



K. R. Eminova
I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia
Russian Federation

Kamila R. Eminova - 6th year student.

8-2, Trubetskaya St., Moscow, 119992



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For citations:


Berestok T.S., Ermoshchenkova M.S., Galkin V.N., Semenova A.B., Didenko V.V., Shatalov V.G., Isaeva O.I., Bogatyreva M.A., Startsevа O.I., Eminova K.R. Adenomyoepithelioma of the breast: a case report. Siberian journal of oncology. 2025;24(6):173-182. (In Russ.) https://doi.org/10.21294/1814-4861-2025-24-6-173-182

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ISSN 1814-4861 (Print)
ISSN 2312-3168 (Online)