A CASE REPORT OF DIFFICULT DIAGNOSIS IN THE PATIENT WITH LARYNGEAL CANCER
https://doi.org/10.21294/1814-4861-2016-15-5-15-22
Abstract
We present a case of the difficult morphological verification and ambiguous interpretation of immunohistochemical examination of cervical lymph nodes metastases from unknown primary tumor with late clinical diagnosis of laryngeal cancer. The detailed morphological features of metastases in cervical lymph nodes from unknown primary tumor were described. External beam radiotherapy to regional cervical lymph nodes in patients with unknown primary tumor can result in reduction and even regression of the primary tumor, thus making the detection of the primary tumor difficult. The time of diagnosis of the primary laryngeal tumor was 2 year and 4 months.
About the Authors
D. V. GavrilyukRussian Federation
MD, PhD, Associate Professor, Department of Oncology and Radiation Therapy with Course of Postgraduate Education, Krasnoyarsk State Medical University named after Professor V.F. Voyno-Yasenetsky (Krasnoyarsk, Russian Federation)
M. V. Avdeenko
Russian Federation
MD, PhD, Head of Surgical Head and Neck Oncology Department, Krasnoyarsk Regoinal Clinical Oncology Dispensary named after A.I. Kryzhanovsky (Krasnoyarsk, Russian Federation)
R. A. Zukov
Russian Federation
MD, DSc, Associate Professor, Head of Department of Oncology and Radiation Therapy with Course of Postgraduate Education, Krasnoyarsk State Medical University named after Professor V.F. Voyno-Yasenetsky (Krasnoyarsk, Russian Federation)
S. Yu. Chizhevskaya
Russian Federation
MD, DSc, Leading researcher, Department head and neck tumors, Cancer Research Institute, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences (Tomsk, Russian Federation)
References
1. Komarov I.G., Komov D.V. Metastases from unknown primary tumors. М.: Triada -Х, 2002; 2002, 136 p. [in Russian]
2. Rudyk А.N. Zinchenko S.V., Khasanov R.Sh., Khamidullin R.G., Chernyshev V.A. Diagnosis and treatment outcomes in patients with squamous cell cancer metastases in lymph nodes of the neck with no detectable primary tumors. Siberian Journal of Oncology. 2010; 1: 64–67. [in Russian]
3. Briasoulis E., Pavlidis N., Felip E; ESMO Guidelines Working Group. Cancers of unknown primary site: ESMO Clinical Recommendation for diagnosis, treatment and follow-up. Ann Oncol. 2008 May; 19 Suppl 2: ii106-7. doi: 10.1093/annonc/mdn104.
4. Kali V.V., Birina L.M., Volkova V.L. Cervical lymph node metastases from unknown primary tumor. Palliative medicine and rehabilitation. 2010; 1: 68–70. [in Russian]
5. Bugat R., Bataillard A., Lesimple T., Voigt J.J., Culine S., Lortholary A., Merrouche Y., Ganem G., Kaminsky M.C., Negrier S., Perol M., Laforêt C., Bedossa P., Bertrand G., Coindre J.M., Fizazi K.; FNCLCC. Summary of the Standarts, Ootions and Recommendation for the management of patients with carcinoma of unknown primary site. Br J Cancer. 2003 Aug; 89 Suppl 1: S59–66.
6. Novik А.V., Zhabina А.S. Biomarkers for diagnosis and choice of the treatment tactics for patients with carcinomas of unknown primary origin. Practical Oncology. 2011; V. 12, № 4: 178–184. [in Russian]
7. Chizhevskaya S.Yu., Kitsmanyuk Z.D., Musabaeva L.I. The use of 6 MeV fast neutrons in the treatment of head and neck tumors/ Fast neutrons in the treatment of cancer patients/edited by Prof. Musabaeva. Tomsk, 2000: 29–82. [in Russian]
8. Muhamedov M.R., Cheremisina O.V., Chojnzonov E.L., Kul’bakin D.E., Balackaja L.N., Vasil’ev N.V., Gjunter V.Je. A modern look at an integrated approach to the diagnosis, treatment and rehabilitation of patients with laryngeal cancer. Russian otorhinolaryngology. 2012; 3: 78–84. [in Russian]
9. Histological classification of laryngeal carcinoma (WHO, 2005) [Internet]. Available from: http://omr.by/sites/default/files/struktura/6_Laryngeal_Cancer.pdf. [in Russian]
10. Endolaryngeal and epilaryngeal laryngeal carcinoma [Internet]. Available from: http://meduniver.com/Medical/gistologia/508.html. [in Russian]
11. Paltsev М.А., Anichkov N.N. Digestive system diseases. Pathologic Anatomy. Vol. 2, part. 1. М., 2005: 512 p. [in Russian
Review
For citations:
Gavrilyuk D.V., Avdeenko M.V., Zukov R.A., Chizhevskaya S.Yu. A CASE REPORT OF DIFFICULT DIAGNOSIS IN THE PATIENT WITH LARYNGEAL CANCER. Siberian journal of oncology. 2016;15(5):99-103. (In Russ.) https://doi.org/10.21294/1814-4861-2016-15-5-15-22