COMPARISON OF CONVENTIONAL RADIATIOTHERAPY AND ACCELERATED HYPERFRACTIONATED RADIATIOTHERAPY IN CHEMORADIATION TREATMENT FOR SMALL CELL LUNG CANCER
Abstract
The 5-year treatment outcomes of 69 patients with stage IIA–IIIA locally advanced small cell lung cancer have been presented. Accelerated hyperfractionated radiotherapy was administered in the uneven daily dose fractionation (single dose of 1 + 1,5 Gy with a 5–6
hour interval to a total dose of 60–70 Gy) depending on the health status and lung function. The complete response was achieved in 13 (42 %) patients, the median survival was 28 months and the 5-year survival rate was 26,2 %. Grade III lung and pericardium toxicities (according to RTOG toxicity scale) were observed in 3,2 % and 6,5 % of patients, respectively. No grade III–IV radiation-induced blood and esophageal damages were found.
hour interval to a total dose of 60–70 Gy) depending on the health status and lung function. The complete response was achieved in 13 (42 %) patients, the median survival was 28 months and the 5-year survival rate was 26,2 %. Grade III lung and pericardium toxicities (according to RTOG toxicity scale) were observed in 3,2 % and 6,5 % of patients, respectively. No grade III–IV radiation-induced blood and esophageal damages were found.
About the Authors
I. A. Gulidov
Medical Radiological Research Center RAMS
Russian Federation
Russian Federation
A. G. Zolotkov
Medical Radiological Research Center RAMS
Russian Federation
Russian Federation
Yu. S. Mardynsky
Medical Radiological Research Center RAMS
Russian Federation
Russian Federation
I. N. Ivanova
Medical Radiological Research Center RAMS
Russian Federation
Russian Federation
L. V. Kursova
Medical Radiological Research Center RAMS
Russian Federation
Russian Federation
D. V. Gogolin
Medical Radiological Research Center RAMS
Russian Federation
Russian Federation
Yu. A. Ragulin
Medical Radiological Research Center RAMS
Russian Federation
Russian Federation
References
1. Бычков М. Б. Мелкоклеточный рак лёгкого. Руководство по химиотерапии опухолевых заболеваний / Под ред. Н.И. Переводчиковой. М., 2006. С. 203–208.
2. Золотков А.Г., Мардынский Ю. С., Гулидов И.А. Терапевтическая радиология. Руководство для врачей «Лучевая терапия опухолей лёгких» / Под ред. А.Ф. Цыба, Ю.С. Мардынского. М., 2010. С. 170–173.
3. Золотков А.Г., Мардынский Ю.С., Гулидов И.А. и др. Повышение эффективности лучевой терапии рака легкого: клинические и экономические проблемы // Клиническая радиология. 2008. № 3. С. 16–20.
4. Курсова Л.В., Рагулин Ю.А., Пасов В.Н., Иванова И.Н. Лечение больных лучевым экссудативным перикардитом // Российский онкологический журнал. 2010. № 1. С. 37–41.
5. Лучевая терапия в лечении рака: Практическое руководство / Под ред. рабочей группы ВОЗ. М., 2000. С. 101–114.
6. Скрипчак Ю.В., Кононова Г.В., Асахин С.М. и др. Лучевая терапия при мелкоклеточном раке легкого: эволюция, современное состояние, перспективы // Сибирский онкологический журнал. 2011. № 6 (48). С. 74–82.
7. Turrisi A.T., Kim K., Blum R. et al. Twice-daily compared with once-daily thoracic radiotherapy in limited small-cell lung cancer treated concurrently with cisplatin and etoposide // N. Engl. J. Med. 2011. Vol. 340 (4). P. 265–271.
8. Gaspar L.E. Limited small cell lung cancer (stage 1-3): observation from the NCL // ASCO. 2004. Abs. 7042.
9. Komaki R., Paulus R., Ettinger D.S. et al. Phase II Study of Accelerated High-Dose Radiotherapy With Concurrent Chemotherapy for Patients With Limited Small-Cell Lung Cancer: Radiation Therapy Oncology Group Protocol 0239 // Int. J. Radiat. Oncol. Biol. Phys. 2012. Vol. 83 (4). P. 531–536.
10. Thatcher N. Some treatment concepts in SCLC // VII Eur. Conf. Perspectives in lung cancer. Athens, 2006. P. 67–73.
11. Quioix E. Is there are improvement of survival in SCLC patients? // II Intern. Conf. New perspectives in the treatment of SCLC. Lausanne, 2002. P. 129–130.
12.
Review
For citations:
Gulidov I.A., Zolotkov A.G., Mardynsky Yu.S., Ivanova I.N., Kursova L.V., Gogolin D.V., Ragulin Yu.A. COMPARISON OF CONVENTIONAL RADIATIOTHERAPY AND ACCELERATED HYPERFRACTIONATED RADIATIOTHERAPY IN CHEMORADIATION TREATMENT FOR SMALL CELL LUNG CANCER. Siberian journal of oncology. 2013;(1):12-15. (In Russ.)
Views:
624
Email this article 
