HEAD AND NECK SQUAMOUS CELL CARCINOMA DEPENDING ON THE MORPHOLOGICAL CHARACTERISTICS OF THE PRIMARY TUMOR
https://doi.org/10.21294/1814-4861-2017-16-2-20-26
Abstract
Objective: to analyze the association of 5 types of cellular structures of squamous cell carcinoma with major clinical and morphological tumor characteristics.
Material And Methods. The main clinical and morphological characteristics of the primary tumor were assessed in 74 patients.
Results. Single tumor cells and structures formed by polymorphic cells were observed in primary tumor more often in the patients with metastatic lymph nodes than in patients with intact lymph nodes. Furthermore, inflammatory reaction in the patients with metastatic lymph nodes was significantly lower than in the patients with intact lymph nodes.
Conclusion. Morphological heterogeneity of the tumor allows us to suggest the clinical course of the head and neck squamous cell carcinoma.
About the Authors
V. A. Bychkov
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
Russian Federation
Bychkov Vyacheslav A. - MD, PhD, Senior Researcher, Laboratory of Viral Oncology.
634009, Tomsk, Kooperativny Street, 5. E-mail: va.bych@gmail.com. SPIN-code: 6174-4896
L. N. Bondar
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
Russian Federation
Bondar Lyudmila N. - MD, physician-pathologist, Department of Pathological Anatomy.
634009, Tomsk, Kooperativny Street, 5. E-mail: bondaroncology@mail.ru. SPIN-code: 2620-1353
E. L. Choynzonov
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences; Siberian State Medical University
Russian Federation
Russian Federation
Choynzonov Evgeny L. - MD, Professor, Academician of RAS, Director of TNRMC RAS, Head of Oncology Department of SSMU.
634009, Tomsk, Kooperativny Street, 5; 634055, Tomsk, Moskovsky trakt, 22. E-mail: center@tnimc.ru, nii@oncology.tomsk.ru. SPIN-code: 2240-8730
V. M. Perelmuter
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
Russian Federation
Perelmuter Vladimir M. - MD, Professor, Head of Department of Pathological Anatomy and Cytology, Cancer Research Institute, TNRMC RAS, Professor of Department of Pathological Anatomy of SSMU.
634009, Tomsk, Kooperativny Street, 5. SPIN-code: 6252-5319
References
1. Stewart B.W., Wild C.P. World Cancer Report 2014. International Agency for Research on Cancer. 2014; 953.
2. Siegel R.L., Miller K.D., Jemal A. Cancer statistics 2015. CA Cancer J Clin. 2015 Jan-Feb; 65 (1): 5–29. doi: 10.3322/caac.21254.
3. Pisareva L.F., Choinzonov E.L., Turina I.N., Odintsova I.N., Shoikhet Ya.N., Lazarev A.F., Yudin S.V., Kosykh N.E. Epidemiological research of cancer in the region of Siberia and Far East. Dal’nevostochnyi meditsinskii zhurnal. 2005; 1: 51–55 [in Russian].
4. Takhauov R.M., Choinzonov E.L., Pisareva L.F., Karpov A.B., Odintsova I.N. The incidence of malignant tumors of the population of Tomsk region. Zdravookhranenie Rossiiskoi Federatsii. 2003; 2: 30–32 [in Russian].
5. Grandis J.R., Pietenpol J.A., Greenberger J.S., Pelroy R.A., Mohla S. Head and neck cancer: meeting summary and research opportunities. Cancer Res. 2004 Nov 1; 64 (21): 8126–9.
6. Sjögren E.V., Wiggenraad R.G., Le Cessie S., Snijder S., Pomp J., Baatenburg de Jong R.J. Outcome of radiotherapy in T1 glottic carcinoma: a population-based study. Eur Arch Otorhinolaryngol. 2009 May; 266 (5): 735–44. doi: 10.1007/s00405-008-0803-9.
7. Takes R.P., Rinaldo A., Silver C.E., Haigentz M.Jr., Woolgar J.A., Triantafyllou A., Mondin V., Paccagnella D., de Bree R., Shaha A.R., Hartl D.M., Ferlito A. Distant metastases from head and neck squamous cell carcinoma. Part I. Basic aspects. Oral Oncol. 2012 Sep; 48 (9): 775–9. doi: 10.1016/j.oraloncology.2012.03.013.
8. Prince M.E., Ailles L.E. Cancer stem cells in head and neck squamous cell cancer. Clin Oncol. 2008 Jun 10; 26 (17): 2871–5. doi: 10.1200/JCO.2007.15.1613.
9. Goldson T.M., Han Y., Knight K.B., Weiss H.L., Resto V.A. Clinicopathological predictors of lymphatic metastasis in HNSCC: implications for molecular mechanisms of metastatic disease. J Exp Ther Oncol. 2010; 8 (3): 211–21.
10. Klisho E.V., Kondakova I.V., Choinzonov E.L., Cheremisina O.Y., Chizhevskaya S.Yu., Shishkin D.А. Прогностическая значимость определения металлопротеиназ и их тканевых ингибиторов в сыворотке крови больных плоскоклеточными карциномами головы и шеи. Oncosurgery. 2011; 3 (1): 20–25. [in Russian]
11. Savenkova O.V., Zav’yalova M.V., Bychkov V.A., Choinzonov E.L., Perel’muter V.M. Association of the expression of matrix metalloproteinases with the morphological heterogeneity, differentiation and lymph node metastasis in laryngeal squamous cell carcinoma. Siberian Journal of Oncology. 2015; 1: 51–58 [in Russian]
12. Salgado R., Denkert C., Demaria S., Sirtaine N., Klauschen F., Pruneri G., Wienert S., Van den Eynden G., Baehner F.L., Penault-Llorca F., Perez E.A., Thompson E.A., Symmans W.F., Richardson A.L., Brock J., Criscitiello C., Bailey H., Ignatiadis M., Floris G., Sparano J., Kos Z., Nielsen T., Rimm D.L., Allison K.H., Reis-Filho J.S., Loibl S., Sotiriou C., Viale G., Badve S., Adams S., Willard-Gallo K., Loi S. The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: recommendations by an International TILs Working Group 2014. Ann Oncol. 2015 Feb; 26 (2): 259–71. doi: 10.1093/annonc/mdu450.
13. Szentkúti G., Dános K., Brauswetter D., Kiszner G., Krenács T., Csákó L., Répássy G., Tamás L. Correlations between prognosis and regional biomarker profiles in head and neck squamous cell carcinomas. Pathol Oncol Res. 2015 Jul; 21 (3): 643–50. doi: 10.1007/s12253-014-9869-4.
14. Satpute P.S., Hazarey V., Ahmed R., Yadav L. Cancer stem cells in head and neck squamous cell carcinoma: a review. Asian Pac J Cancer Prev. 2013; 14 (10): 5579–87.
15. Scanlon C.S., Van Tubergen E.A., Inglehart R.C., D’Silva N.J. Biomarkers of epithelial-mesenchymal transition in squamous cell carcinoma. J Dent Res. 2013 Feb; 92 (2): 114–21. doi: 10.1177/0022034512467352.
16. Smith A., Teknos T.N., Pan Q. Epithelial to mesenchymal transition in head and neck squamous cell carcinoma. Oral Oncol. 2013 Apr; 49 (4): 287–92. doi: 10.1016/j.oraloncology. 2012.10.009.
17. Aceto N., Bardia A., Miyamoto D.T., Donaldson M.C., Wittner B.S., Spencer J.A., Yu M., Pely A., Engstrom A., Zhu H., Brannigan B.W., Kapur R., Stott S.L., Shioda T., Ramaswamy S., Ting D.T., Lin C.P., Toner M., Haber D.A., Maheswaran S. Circulating tumor cell clusters are oligoclonal precursors of breast cancer metastasis. Cell. 2014 Aug 28; 158 (5): 1110–22. doi: 10.1016/j.cell.2014.07.013.
18. Paget S. The distribution of secondary growths in cancer of the breast. 1889. Cancer Metastasis Rev. 1989 Aug; 8 (2): 98–101.
19. Duray A., Demoulin S., Hubert P., Delvenne P., Saussez S. Immune suppression in head and neck cancers: a review. Clin Dev Immunol. 2010; 701657. doi: 10.1155/2010/701657.
20. Czystowska M., Gooding W., Szczepanski M.J., Lopez-Abaitero A., Ferris R.L., Johnson J.T., Whiteside T.L. The immune signature of CD8(+) CCR7(+) T cells in the peripheral circulation associates with disease recurrence in patients with HNSCC. Clin Cancer Res. 2013 Feb 15; 19 (4): 889–99. doi: 10.1158/1078-0432.CCR-12-2191.
21. Murphy K.M., Reiner S.L. The lineage decisions of helper T cells. Nature Reviews Immunology. 2002; 2: 933–944.
22. Sparano A., Lathers D.M., Achille N., Petruzzelli G.J., Young M.R. Modulation of Th1 and Th2 cytokine profiles and their association with advanced head and neck squamous cell carcinoma. Otolaryngol Head Neck Surg. 2004 Nov; 131 (5): 573–6.
23. Fridman W.H., Pagès F., Sautès-Fridman C., Galon J. The immune contexture in human tumours: impact on clinical outcome. Nat Rev Cancer. 2012 Mar 15; 12 (4): 298–306. doi: 10.1038/nrc3245.
24. Wieder T., Braumüller H., Kneilling M., Pichler B., Röcken M. T cell-mediated help against tumors. Cell Cycle. 2008 Oct; 7 (19): 2974–7.
Review
For citations:
Bychkov V.A., Bondar L.N., Choynzonov E.L., Perelmuter V.M. HEAD AND NECK SQUAMOUS CELL CARCINOMA DEPENDING ON THE MORPHOLOGICAL CHARACTERISTICS OF THE PRIMARY TUMOR. Siberian journal of oncology. 2017;16(2):20-26. (In Russ.) https://doi.org/10.21294/1814-4861-2017-16-2-20-26
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