POLYSACCHARIDES TUSSILAGOFARFARA L. REDUCE MYELOSUPPRESSION INDUCED BY CISPLATIN AND ETOPOSIDE
https://doi.org/10.21294/1814-4861-2017-16-4-42-48
Abstract
The purpose of the study was to investigate the influence of polysaccharides Tussilagofarfara L. on erythroid sprout hematopoiesis, tumor growth and metastasis in mice with Lung cancer-67 during therapy with cisplatin and etoposide. It was found that the use of polysaccharides reduces myelosuppression induced by cytostatics of erythroidal sprout hematopoiesis and leads to increase anti-tumor and anti-metastatic effect of chemotherapy.
About the Authors
E. A. Safonova
Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences.
Russian Federation
Russian Federation
Safonova Elena A., PhD, Research Scientist, Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences.
3, Lenina avenue, 634028-Tomsk, Russia.
K. A. Lopatina
Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences; National Research Tomsk State University.
Russian Federation
Russian Federation
Lopatina Ksenija A., PhD, Research Scientist, Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences.
3, Lenina avenue, 634028-Tomsk, Russia.
T. G. Razina
Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences.
Russian Federation
Russian Federation
Razina Tatjana G., DSc, Senior Researcher, Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences.
3, Lenina avenue, 634028-Tomsk, Russia.
E. P. Fedorova
Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences.
Russian Federation
Russian Federation
Fedorova Elena P., PhD, Research Scientist, Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences.
3, Lenina avenue, 634028-Tomsk, Russia.
E. P. Zueva
Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences.
Russian Federation
Russian Federation
Zueva Elena P., DSc, Professor, Head of the laboratory oncopharmacology, Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences.
3, Lenina avenue, 634028-Tomsk, Russia.
A. M. Gurev
Siberian State Medical University.
Russian Federation
Russian Federation
Gurev Artem M., DSc, Siberian State Medical University.
2, Moskovskiy Tract, 634050-Tomsk, Russia.
M. V. Belousov
Siberian State Medical University.
Russian Federation
Russian Federation
Belousov Mihail V.,DSc, Professor, Siberian State Medical University.
2, Moskovskiy Tract, 634050-Tomsk, Russia.
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Review
For citations:
Safonova E.A., Lopatina K.A., Razina T.G., Fedorova E.P., Zueva E.P., Gurev A.M., Belousov M.V. POLYSACCHARIDES TUSSILAGOFARFARA L. REDUCE MYELOSUPPRESSION INDUCED BY CISPLATIN AND ETOPOSIDE. Siberian journal of oncology. 2017;16(4):42-48. (In Russ.) https://doi.org/10.21294/1814-4861-2017-16-4-42-48
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