OUTBREAK OF HOSPITAL-AQUIRED INFECTION CAUSED BY MULTIDRUG RESISTANT STRAINS OF K. PNEUMONIAE
Abstract
The prevalence of extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae is increasing globally and is a major clinical concern. Carbapenemase-producing strains (K. Pneumoniaе) can develop resistance to nearly all known antibiotics and in 40-50% of cases lead to death of the patient. Epidemiological studies of outbreaks of infections caused by pathogenic microorganisms are carried out in most clinics of the world. Creation of hospital epidemiology program allows the control of hospital’s infection. In September, 2013, the outbreak of infection caused by MDR strains of K. Pneumoniaе was registered at the N.N. Blokhin Russian Cancer Research Center, and the epidemiologic study was conducted.
About the Authors
Z. V. Grigoryevskaya
Лаборатория микробиологической диагностики и лечения инфекций в онкологии ФГБУ «РОНЦ им. Н.Н. Блохина» РАМН
Russian Federation
Russian Federation
I. N. Petukhova
Лаборатория микробиологической диагностики и лечения инфекций в онкологии ФГБУ «РОНЦ им. Н.Н. Блохина» РАМН
Russian Federation
Russian Federation
N. V. Dmitrieva
Лаборатория микробиологической диагностики и лечения инфекций в онкологии ФГБУ «РОНЦ им. Н.Н. Блохина» РАМН
Russian Federation
Russian Federation
References
1. Sidorenko S.V., Tishkov V.I. Molecular basis of radioresistance to antibiotics // Uspehi biologicheskoj himii. 2004. Vol. 44. P. 263–306. [in Russian]
2. Bush K. Carbapenemases: Partners in crime // J. Global Antimicrobial Resist. 2013. Vol. 1. P. 7–16.
3. Center for Disease Control and Prevention, USA. www.cdc.gov
4. Central Intelligence Agency. The global infections diseasese threat and its implications for the United States. 1999. www.odci.gov/cia/publications/nie/report/nie99and17.html
5. Davies T.A., Queenan M., Morrow B.J., Shang W., Amsler K., He W., Lynch A.S., Pillar C., Flamm R.K. Longitudial survey of carbapenem resistant and resistance mechanisms in Enterobacteriacae and non-fermenters from USA in 2007–2009 // J. Antimicrobial Chemother. 2011. Vol. 66. P. 2298–2307. doi: 10.1093/jac/dkr290.
6. Guidance for Control of Carbapenem-Resistant Enterobacteriaceae (CRE), 2012 CDC (www.cdc.gov)
7. Kaase M. Carbapenemases in gram-negative bacteria : Current data and trends of resistance resulting from the work of national reference centres // Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2012. Vol. 55 (11–12). P. 1401–1404. doi: 10.1007/s00103-012-1552-x.
8. Kallen A., Guh A. United states centers for disease control and prevention issue updated guidance for tackling carbapenem-resistant enterobacteriaceae // Eurosurveillance. 2012. Vol. 17. Issue 26. P. 28.
9. Park Y.J., Yu J.K., Park K.J., Park Y.G., Lee S., Kim S.Y., Jeong S.H. Prevalence and contributing factors of nonsusceptibility to imipenem and meropenem in extended-spectrum beta-lactamase- producing Klebsiella pneumoniae and Escherichia coli // Microbiol. Infec. Dis. 2011. Vol. 71. P. 87–89. doi: 10.1016.
10. Poirel L., Potron A., Nordmann P. OXA-48-Like carbapenemases: The phantom menace // J. Antimicrobial Chemother. 2012. Vol. 67. P. 1597–1606. doi: 10.1093/jac/dks121.
11. Poulou A., Voulgary E., Vrioni G., Xidopoulos G., Pliagkos A., Chatzipantazi V., Markou F., Tsakris A. Imported KPC- producing Klebsiella pneumoniea clones in a Greek hospital: impact of infections control measures to restrain their dissemination // J. Clin. Microbiol. 2012. Vol. 50. P. 2618–2623. doi: 10.1128/JCM.00459-12.
12. Snitkin E.S., Zelazny A.M., Thomas P.J., Stock F.; NISC Comparative Sequencing Program Group, Henderson D.K., Palmore T.N., Segre J.A. Tracking a Hospital Outbreak of Carbapenem-Resistant Klebsiella pneumoniae with Whole-Genome Sequencing // Sci. Transl. Med. 2012. Vol. 4 (148). P. 148ra116. doi: 10.1126/scitranslme.
Review
For citations:
Grigoryevskaya Z.V., Petukhova I.N., Dmitrieva N.V. OUTBREAK OF HOSPITAL-AQUIRED INFECTION CAUSED BY MULTIDRUG RESISTANT STRAINS OF K. PNEUMONIAE. Siberian journal of oncology. 2014;(2):5-8. (In Russ.)
Views:
985
Email this article 
