BRCA1GENE EXPRESSION IN ENDOCRINE TUMORS OF THE GASTROINTESTINAL TRACT
Abstract
Results of molecular genetic study of BRCA1gene expression in patients with endocrine tumors of the gastrointestinal tract were presented. Based on the analysis of survival rates in patients with endocrine tumors of the gastrointestinal tract, the BRCA1expression level was suggested can be used as a prognostic criterion and as a factor determining the advisability of administration of platinum-based drugs. It was found that the more aggressive neuroendocrine tumors had the lower BRCA1expression. Therefore, administration of platinumcontaining chemotherapy is unlikely to offer any benefit for these patients.
About the Authors
I. G. Gafton
N.N. Petrov Research Institute of Oncology, St.-Petersburg
I.P. Pavlov State Medical University, St.-Petersburg
Russian Federation
68, Leningradskaya Street 19775-St.-Petersburg
Russian Federation
68, Leningradskaya Street 19775-St.-Petersburg
Е. N. Imyanitov
I.I. Mechnikov State Medical University, St.-Petersburg
Russian Federation
Russian Federation
V. V. Semiglasov
N.N. Petrov Research Institute of Oncology, St.-Petersburg
I.P. Pavlov State Medical University, St.-Petersburg
Russian Federation
68, Leningradskaya Street 19775-St.-Petersburg
Russian Federation
68, Leningradskaya Street 19775-St.-Petersburg
D. Е. Matsko
N.N. Petrov Research Institute of Oncology, St.-Petersburg
Russian Federation
Russian Federation
G. I. Gafton
N.N. Petrov Research Institute of Oncology, St.-Petersburg
Russian Federation
Russian Federation
Yu. V. Semiletova
N.N. Petrov Research Institute of Oncology, St.-Petersburg
I.I. Mechnikov State Medical University, St.-Petersburg
Russian Federation
Russian Federation
А. G. Ievleva
N.N. Petrov Research Institute of Oncology, St.-Petersburg
Russian Federation
Russian Federation
А. Е. Mikhnin
N.N. Petrov Research Institute of Oncology, St.-Petersburg
I.I. Mechnikov State Medical University, St.-Petersburg
Russian Federation
Russian Federation
V. G. Lemekhov
N.N. Petrov Research Institute of Oncology, St.-Petersburg
I.I. Mechnikov State Medical University, St.-Petersburg
Russian Federation
Russian Federation
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Review
For citations:
Gafton I.G., Imyanitov Е.N., Semiglasov V.V., Matsko D.Е., Gafton G.I., Semiletova Yu.V., Ievleva А.G., Mikhnin А.Е., Lemekhov V.G. BRCA1GENE EXPRESSION IN ENDOCRINE TUMORS OF THE GASTROINTESTINAL TRACT. Siberian journal of oncology. 2014;(4):11-15. (In Russ.)
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