OPTIMIZATION OF THE EXTENT OF SURGERICAL TREATMENT FOR INVASIVE CERVICAL CANCER
Abstract
The study included 26 patients with stage Ia1 – Ib1 cervical cancer who underwent organ-preserving surgery (transabdominal trachelectomy). To visualize sentinel lymph nodes, lymphoscintigraphy with injection of radioactive lymphotropic isotope, 99mTc-labelled nanocolloid, was performed the day before surgery. Intraoperative identification of sentinel lymph nodes using gamma probe was carried out to assess which lymph nodes had taken up the radionuclide. Detection of sentinel lymph nodes in cervical cancer patients can accurately predict the pelvic lymph node status, assess the stage of the disease, individualize the extent of surgery and determine indications for organpreserving surgery.
About the Authors
A. L. Chernyshova
Cancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk
Russian Federation
Russian Federation
L. A. Kolomiets
Cancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk
Siberian State Medical University, Tomsk
Russian Federation
Russian Federation
I. G. Sinilkin
Cancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk
Russian Federation
Russian Federation
V. I. Chernov
Cancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk
Russian Federation
Russian Federation
O. V. Pankova
Cancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk
Russian Federation
Russian Federation
А. Yu. Lyapunov
Siberian State Medical University, Tomsk
Russian Federation
Russian Federation
References
1. Baggish M.S., Karram M.K. Atlas of pelvic anatomy and gynecologic surgery. London: Elsevier Ltd., 2009. 1172 p. [in Russian]
2. Semiglazov V.F. New trends in organ-preserving surgery for malignant neoplasms. SPb., 2009. P. 12–24. [in Russian]
3. Chernov V.I., Afanas’ev S.G., Sinilkin I.G., Tickaja A.A., Avgustinovich A.V. Radionuclide diagnosis for detection of sentinel lymph nodes // Sibirskij onkologicheskij zhurnal. 2008. № 4. P. 5–10. [in Russian]
4. Chernyshova A.L., Ljapunov A.Ju., Kolomiec L.A., Chernov V.I., Sinilkin I.G. Sentinel lymph node detection in surgical treatment of cervical cancer // Sibirskij onkologicheskij zhurnal. 2012. № 3. P. 28–33. [in Russian]
5. Chernyshova A.L., Kolomiec L.A., Krasil'nikov S.Je. Organ-preserving surgery for patients with invasive uterine cervix cancer // Sibirskij onkologicheskij zhurnal. 2011. № 2. P. 72–78. [in Russian]
6. Chojnzonov E.L., Pisareva L.F., Cherdynceva N.V., Bojarkina A.P., Odincova I.N., Martynova N.A. Cancer morbidity in Siberia and Russian Far East. The state of health care service of cancer patients and the ways of its improvement // Bjulleten’ Sibirskogo otdelenija Rossijskoj akademii medicinskih nauk. 2004. № 2. P. 41–47. [in Russian]
7. Chojnzonov E.L., Pisareva L.F., Zhujkova L.D. Quality of cancer diagnosis in Tomsk region during the period 2004-2009 // Sibirskij onkologicheskij zhurnal. 2011. № 3. P. 29–34. [in Russian]
8. Abu-Rustum N.R., Knoury-Collado F., Gemignani M.L. Tehniques of sentinel lymph node identification for early-stage cervical and uterine cancer // Gynecol. Oncol. 2008. Vol. 111 (2 suppl). S. 44–50. doi: 10.1016/j. ygyno.2008.07.027.
9. Abu-Rustum N.R., Neubauer N., Sonoda Y., ParkK.J., Gemignani M., Alektiar K.M., Tew W., Leitao M.M., Chi D.S., Barakat R.R. Surgical and pathologic outcomes of fertility-sparing radical abdominal trachelectomy for FIGO stage IB1 cervical cancer // Gynecol. Oncol. 2008. Vol. 111 (2). P. 261–264. doi: 10.1016/j.ygyno.2008.07.002.
10. Altgassen C., Hertel H., Brandstädt A., Köhler C., Dürst M., Schneider A. Multicenter validacion study of the sentinentel lymph node concept in cervical cancer: AGO Study Group // J. Clin. Oncol. 2008. Vol. 26. P. 2943–2951. doi: 10.1200/JCO.2007.13.8933.
11. Darlin L., Persson J., Bossmar T., Lindahl B., Kannisto P., Måsbäck A., Borgfeldt C. The sentinel node concept in early cervical cancer performs well in tumors smaller than 2 cm // Gynecol. Oncol. 2010. Vol. 117 (2). P. 266–269. doi: 10.1016/j.ygyno.2010.01.035.
12. Diaz J.P., Sonoda Y., Leitao M.M., Zivanovic O., Brown C.L., Chi D.S., Barakat R.R., Abu-Rustum N.R. Oncologic outcome of fertilitysparing radical trachelectomy versus radical hysterectomy for stage IB1 cervical carcinoma // Gynecol. Oncol. 2008. Vol. 111 (2). P. 255–260. doi: 10.1016/j.ygyno.2008.07.014.
13. Du X.L., Sheng X.G., Jiang T., Li Q.S., Yu H., Pan C.X., Lu C.H., Wang C., Song Q.Q. Sentinel lymph node biopsy as guidance for radical trachelectomy in young patients with early stage cervical cancer // BMC Cancer. 2011. Vol. 11. P. 157. doi: 10.1186/1471-2407-11-157.
14. Eiriksson L.R., Covens A. Sentinel lymph node mapping in cervical cancer: the future? // BJOG. 2012. Vol. 119 (2). P. 129–133. doi: 10.1111/j.1471-0528.2011.03134.x
15. Fader A.N., Edwards R.P., Cost M., Kanbour-Shakir A., Kelley J.L., Schwartz B., Sukumvanich P., Comerci J., Sumkin J., Elishaev E., Rohan L.C. Sentinel lymph node biopsy in early-stage cervical cancer: utility of intraoperative versus postoperative assessment // Gynecol. Oncol. 2008. Vol. 111 (1). P. 13–17. doi: 10.1016/j.ygyno.2008.06.009.
16. Hertel H., Köhler C., Grund D., Hillemanns P., Possover M., Michels W., Schneider A. Association of Gynecologic Oncologists (AGO): Radical vaginal trachelectomy (RVT) combined with laparoscopic pelvic lymphadenectomy: prospective multicenter study of 100 patients with early cervical cancer // Gynecol. Oncol. 2006. Vol. 103 (2). P. 506–511.
17. Kara P.P., Ayhan A., Caner B., Gültekin M., Ugur O., Bozkurt M.F., Usubutun A. Sentinel lymph node detection in early stage cervical cancer: a prospective study comparing preoperative lymphoscintigraphy, intraoperative gamma probe, and blue dye // Ann. Nucl. Med. 2008. Vol. 22 (6). P. 487–494. doi: 10.1007/s12149-008-0144-1.
18. Levenback C. Update on sentinel lymph node biopsy in gynecologic cancers // Gynecol. Oncol. 2008. Vol. 111(2 Suppl). S. 42–43. doi: 10.1016/j.ygyno.2008.07.029.
19. Niikura H., Okamura C., Akahira J., Takano T., Ito K., Okamura K., Yaegashi N. Sentinel lymph node detection in early cervical cancer with combination 99mTc phytate and patent blue // Gynecol. Oncol. 2004. Vol. 94. P. 528–532.
20. Ogawa S., Kobayashi H., Amada S., Yahata H., Sonoda K., Abe K., Baba S., Sasaki M., Kaku T., Wake N. Sentinel node detection with 99mTc phytate alone is satisfactory for cervical cancer patients undergoing radical hysterectomy and pelvic lymphadenectomy // Int. J. Clin. Oncol. 2010. Vol. 15 (1). P. 52–58. doi: 10.1007/s10147-009-0010-8.
21. Seong S.J., Park H., Yang K.M., Kim T.J., Lim K.T., Shim J.U., Park C.T., Lee K.H. Detection of sentinel lymph nodes in patients with early stage cervical cancer // J. Korean Med. Sci. 2007. Vol. 22 (1). P. 105–109.
22. Yamashita T., Katayama H., Kato Y., Nishiwaki K., Hayashi H., Miyokawa N., Sengoku K. Management of pelvic lymph nodes by sentinel node navigation surgery in the treatment of invasive cervical cancer // Int. J. Gynecol. Cancer. 2009. Vol. 19 (6). P. 1113–1118. doi: 10.1111/ IGC.0b013e3181a83d65.
Review
For citations:
Chernyshova A.L., Kolomiets L.A., Sinilkin I.G., Chernov V.I., Pankova O.V., Lyapunov А.Yu. OPTIMIZATION OF THE EXTENT OF SURGERICAL TREATMENT FOR INVASIVE CERVICAL CANCER. Siberian journal of oncology. 2014;(4):25-30. (In Russ.)
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