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CYP2D6-ГЕНОТИПИРОВАНИЕ В ОЦЕНКЕ ЭФФЕКТИВНОСТИ ТЕРАПИИ ТАМОКСИФЕНОМ У БОЛЬНЫХ ГОРМОНОПОЗИТИВНЫМ РАКОМ МОЛОЧНОЙ ЖЕЛЕЗЫ

https://doi.org/10.21294/1814-4861-2017-16-6-73-85

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Аннотация

Тамоксифен является препаратом выбора при эндокринотерапии гормоноположительного рака молочной железы у женщин в репродуктивном периоде. Метаболическая активность тамоксифена в организме определяется активностью фермента CYP2D6, кодируемого одноименным геном: под действием фермента тамоксифен переходит в метаболически активную форму – эндоксифен. Фармакогенетическое тестирование гена CYP2D6 у пациентов с гормоноположительным раком молочной железы поможет прогнозировать эффективность терапии и оценить риск развития побочных эффектов в целях улучшения отдаленных результатов лечения.

 

Об авторах

Л. Н. Любченко
ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России, г. Москва
Россия

доктор медицинских наук, заведующая лабораторией клинической онкогенетики

SPIN-код: 9589-9057



М. Г. Филиппова
ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России, г. Москва
Россия

кандидат медицинских наук, старший научный сотрудник лаборатории клинической онкогенетики

SPIN-код: 1927-6110



Н. И. Мехтиева
ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России, г. Москва
Россия
кандидат медицинских наук, отделение сосудистой и реконструктивной хирургии


Т. А. Шендрикова
ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России, г. Москва
Россия
аспирант


А. В. Семьянихина
ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России, г. Москва
Россия

врач-онколог лаборатории клинической онкогенетики

SPIN-код: 1751-7909



А. В. Снеговой
ФГБУ «Национальный медицинский исследовательский центр онкологии им. Н.Н. Блохина» Минздрава России, г. Москва
Россия

доктор медицинских наук, заведующий отделением амбулаторной химиотерапии (дневной стационар)

SPIN-код: 8398-2396



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Для цитирования:


Любченко Л.Н., Филиппова М.Г., Мехтиева Н.И., Шендрикова Т.А., Семьянихина А.В., Снеговой А.В. CYP2D6-ГЕНОТИПИРОВАНИЕ В ОЦЕНКЕ ЭФФЕКТИВНОСТИ ТЕРАПИИ ТАМОКСИФЕНОМ У БОЛЬНЫХ ГОРМОНОПОЗИТИВНЫМ РАКОМ МОЛОЧНОЙ ЖЕЛЕЗЫ. Сибирский онкологический журнал. 2017;16(6):73-85. https://doi.org/10.21294/1814-4861-2017-16-6-73-85

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Lyubchenko L.N., Filippova M.G., Mekhtieva N.I., Shendrikova T.A., Semaynikhina A.V., Snegovoy A.V. CYP2D6-GENOTYPING IN THE ASSESSMENT OF THE EFFECTIVENESS OF THERAPY WITH TAMOXIFEN IN PATIENTS WITH ADVANCED HORMONE RECEPTOR-POSITIVE BREAST CANCER. Siberian journal of oncology. 2017;16(6):73-85. (In Russ.) https://doi.org/10.21294/1814-4861-2017-16-6-73-85

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ISSN 1814-4861 (Print)
ISSN 2312-3168 (Online)