THE ROLE OF AUTOPHAGY AND ANGIOGENESIS IN COLORECTAL CANCER
https://doi.org/10.21294/1814-4861-2017-16-6-86-92
Abstract
The purpose of the study was a review of available data on the role of autophagy and angiogenesis in the development, progression and prognosis of colorectal cancer. Material and methods. Databases searched were Medline, Cochrane Library and Elibrary. Of 340 studies, 48 were used to write a systematic review. Results. To date, there is a variety of prognostic markers used in the study of pathogenesis, diagnosis and treatment of colorectal cancer. The review describes the molecular mechanisms of the participation of various proteins of autophagy and angiogenesis in the pathogenesis and progression of colorectal cancer, and the potential importance of their use in clinical practice is presented. Conclusion. Many of the existing markers can be used not only in assessing the prognosis, but also sensitivity to chemotherapy. However, the contradictory results of studies with respect to certain proteins require further study, validation, and subsequent introduction into practice.
About the Authors
K. V. Rachkovsky
Siberian State Medical University, Tomsk
Russian Federation
Russian Federation
Postgraduate, Department of Pathological Anatomy and Cytology
SPIN-code: 6814-7094
S. V. Vtorushin
Siberian State Medical University, Tomsk;
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk
Russian Federation
Russian Federation
MD, DSc, Professor, Pathological Anatomy Department, Siberian State Medical University; Senior Researcher of the Department of Pathological Anatomy and Cytology of Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Medical Sciences
SPIN-code: 2442-4720
I. V. Stepanov
Siberian State Medical University, Tomsk;
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk
Russian Federation
Russian Federation
MD, PhD, Assistent Professor, Pathological Anatomy Department
SPIN-code: 5930-3160.
S. S. Naumov
Siberian State Medical University, Tomsk
Russian Federation
student
Russian Federation
student
M. V. Zavyalova
Siberian State Medical University, Tomsk;
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk
Russian Federation
Russian Federation
MD, DSc, Professor, Head of Pathological Anatomy Department, Siberian State Medical University; Senior Researcher of the Department of Pathological Anatomy and Cytology, Tomsk National Research Medical Center of the Russian Academy of Medical Sciences
SPIN-code: 1229-0323
S. G. Afanasyev
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk
Russian Federation
Russian Federation
MD, DSc, Professor, Leading Researcher, Thoracic and Abdominal Department, Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Medical Science
SPIN-code: 9206-3037
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Review
For citations:
Rachkovsky K.V., Vtorushin S.V., Stepanov I.V., Naumov S.S., Zavyalova M.V., Afanasyev S.G. THE ROLE OF AUTOPHAGY AND ANGIOGENESIS IN COLORECTAL CANCER. Siberian journal of oncology. 2017;16(6):86-92. (In Russ.) https://doi.org/10.21294/1814-4861-2017-16-6-86-92
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