Cu/Fe MAGNETIC NANOPARTICLES WITH ANTITUMOR ACTIVITY
https://doi.org/10.21294/1814-4861-2018-17-1-19-25
Abstract
The use of bimetallic nanoparticles of biocompatible metals with magnetic properties is a new approach to combating cancer cells. Nanoparticles of immiscible Fe/Cu metals, with separated phases at the level of one particle, were synthesized by electric explosion of iron and copper wires in an argon atmosphere. To characterize Cu/Fe nanoparticles, X-ray phase analysis, transmission electron microscopy, thermal desorption of nitrogen, and energy-dispersive analysis were used. Our research has shown that synthesized nanoparticles have antitumor activity against Neuro 2A and J 774 cell lines. Such particles may be promising for the development of drugs for magnetic target delivery.
Keywords
magnetic nanoparticles,
electric explosion of metal conductors,
core-shell structure,
segregated structure,
MTT test,
tumor cells
Supporting agencies: Russian Science Foundation, Grant No. 17-19-01319; Russian Academy of Sciences, Fundamental scientific research for 2016-2020
About the Authors
O. V. Bakina
Institute of Strength Physics and Materials Science, Siberian Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
Olga V. Bakina - PhD, Researcher, SPIN-code: 9002-1344.
2/4, pr. Akademichesky, 634021-Tomsk
E. A. Glazkova
Institute of Strength Physics and Materials Science, Siberian Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
Elena А. Glazkova - PhD, Senior Researcher, SPIN-code: 9642-1860.
2/4, pr. Akademichesky, 634021-Tomsk
N. V. Svarovskaya
Institute of Strength Physics and Materials Science, Siberian Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
Natalia V. Svarovskaya - PhD, Senior Researcher, SPIN-code: 3019-7455.
2/4, pr. Akademichesky, 634021-Tomsk
M. S. Korovin
Institute of Strength Physics and Materials Science, Siberian Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
Matvey S. Korovin - MD, PhD, Researcher.
2/4, pr. Akademichesky, 634021-Tomsk; 2, Moskovsky trakt, 634050-Tomsk
A. N. Fomenko
Institute of Strength Physics and Materials Science, Siberian Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
Alla N. Fomenko - Engineer, SPIN-code: 4435-8053.
2/4, pr. Akademichesky, 634021-Tomsk; 2, Moskovsky trakt, 634050-Tomsk
M. I. Lerner
Institute of Strength Physics and Materials Science, Siberian Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
Marat I. Lerner - DSc, Head of Laboratory, SPIN-code: 3247-9864.
2/4, pr. Akademichesky, 634021-Tomsk
А. V. Avgustinovich
Clinical Diagnostic Medical Centre
Russian Federation
Russian Federation
Alexandra V. Avgustinovich - MD, PhD, Head of Department, SPIN-code: 2952-6119.
3, Morskoy Prospekt, 197110-Saint-Petersburg
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Review
For citations:
Bakina O.V., Glazkova E.A., Svarovskaya N.V., Korovin M.S., Fomenko A.N., Lerner M.I., Avgustinovich А.V. Cu/Fe MAGNETIC NANOPARTICLES WITH ANTITUMOR ACTIVITY. Siberian journal of oncology. 2018;17(1):19-25. (In Russ.) https://doi.org/10.21294/1814-4861-2018-17-1-19-25
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