PATHOGENIC AND CORRELATIVE RELATIONSHIP BETWEEN THE LEVEL OF SHORT- CHAIN FATTY ACIDS AND THE INTENSITY OF BIOLOGICAL PROCESS IN CERVICAL CANCER CELLS DURING CANCEROGENESIS
https://doi.org/10.21294/1814-4861-2018-17-1-32-37
Abstract
Background. The change in the spectrum of short-chain fatty acids (SCFA) is known to be one of the links of carcinogenesis.
The aim of study was to assess the correlation between the levels of cell proliferation, apoptosis, cell cycle kinetics and the spectrum of short-chain fatty acids in cervical dysplasia and cancer cells.
Methods. To analyze the association between the variables, the Spearman’s rank correlation was used.
Results. The SCFA is likely to have anti-proliferative, pro-apoptotic, and modulatory effects on the cell cycle phase.
Conclusion. Correlations between the level of SCFA and parameters of apoptosis, necrosis, and cell cycle phases indicates their pathogenetic participation in the cervical carcinogenesis.
Supporting agencies: Russian Federation President Council on Grants for governmental support for young Russian scientists MK-6143.2018.7, agreement No. 14.W01.18.6143-MK of 17.01.18
About the Authors
E. V. Kayukova
Chita State Medical Academy
Russian Federation
Russian Federation
Elena V. Kayukova - MD, PhD, Department of Radiation Diagnostics and Radiation Therapy with a Course of Oncology, AuthorID: 818313.
39A, Gorkogo Str., 672000-Chita
T. E. Belokrinitskaya
Chita State Medical Academy
Russian Federation
Russian Federation
Tatyana E. Belokrinitskaya - MD, Professor, Honored Doctor of the Russian Federation, Head of the Department of Obstetrics and Gynecology, SPIN-code: 7823-5179.
39A, Gorkogo Str., 672000-Chita
T. V. Kayukova
Chita State Medical Academy
Russian Federation
Russian Federation
Tatyana V. Kayukova - MD, PhD, Associate Professor, Department of Radiation Diagnostics and Radiation Therapy with a Course of Oncology, AuthorID: 769200.
39A, Gorkogo Str., 672000-Chita
B. S. Khyshiktuev
Medicom LLC
Russian Federation
Russian Federation
Bair S. Khyshiktuev - MD, DSc, Professor, Deputy General Director for Innovations, SPIN-code: 8572-4313.
150, Mira Prospect, 129366-MoscowReferences
1. Kayukova E.V., Tereshkov P.P. The short chain fatty acid spectrum of cervical dysplasia and cancer cells. Modern Problems of Science and Education. 2015; 2–1. URL: https://www.science-education.ru/ru/article/view?id=18999 (дата обращения: 06.01.2017). [in Russian]
2. Kayukova E.V. Cell proliferation, apoptosis and cell cycle of cervical dysplasia and cancer cell. Physician-Postgraduate. 2015; 2.1 (69): 117–124. [in Russian]
3. Kulicov V.A., Beliaeva L.E. Metabolic reprogramming cancer cells. Newsletter of VGMU. 2013; 12 (2): 6–18. [in Russian]
4. Khyshiktuev B.S., Kayukova E.V., Kayukov V.А., Tereshkov P.P. The spectrum of higher fatty acids tumor tissue of cervical cancer with varying degrees of differentiation. Siberian Journal of Oncology. 2013; 1 (55): 47–51. [in Russian]
5. Alrawi S.J., Schiff M., Carroll R.E., Dayton M., Gibbs J.F., Kulavlat M., Tan D., Berman K., Stoler D.L., Anderson G.R. Aberrant crypt foci. Anticancer Res. 2006; 26: 107–119.
6. Al-Yacoub N., Fecker L.F., Möbs M., Plötz M., Braun F.K., Sterry W., Eberle J. Apoptosis induction by SAHA in cutaneous T-cell lymphoma cells is related to downregulation of c-FLIP and enhanced TRAIL signaling. J Invest Dermatol. 2012 Sep; 132 (9): 2263–74. doi: 10.1038/jid.2012.125.
7. Baumann J., Sevinsky С., Conklin D.S. Lipid biology of breast cancer. Biochim Biophys Acta. 2013 Oct; 1831(10): 1509–17.
8. Canani R.B., Costanzo M.D., Leone L., Pedata M., Meli R., Calignano A. Potential beneficial effects of butyrate in intestinal and extraintestinal diseases. World J Gastroenterol. 2011 Mar 28; 17 (12): 1519–28. doi: 10.3748/wjg.v17.i12.1519.
9. Chen Y.X., Fang J.Y., Lu J., Qiu D.K. Regulation of histone acetylation on the expression of cell cycle-associated genes in human colon cancer cell lines. Zhonghua Yi Xue Za Zhi. 2004 Feb 17; 84 (4): 312–7.
10. Cox M.A., Jackson J., Stanton M., Rojas-Triana A., Bober L., Laverty M., Yang X., Zhu F., Liu J., Wang S., Monsma F., Vassileva G., Maguire M., Gustafson E., Bayne M., Chou C.C., Lundell D., Jenh C.H. Short-chain fatty acids act as antiinflammatory mediators by regulating prostaglandin E(2) and cytokines. World J Gastroenterol. 2009 Nov 28; 15 (44): 5549–57.
11. Das U.N., Мadhavi N. Effect of polyunsaturated fatty acids on drug-sensitive and resistant tumor cells in vitro. Lipids Health Dis. 2011 Sep 14; 10: 159. doi: 10.1186/1476-511X-10-159.
12. Han B.R., You B.R., Park W.H. Valproic acid inhibits the growth of HeLa cervical cancer cells via caspase-dependent apoptosis. Oncol Rep. 2013 Dec; 30(6): 2999–3005. doi: 10.3892/or.2013.2747.
13. Steliou K., Boosalis M.S., Perrine S.P., Sangerman J., Faller D.V. Butyrate histone deacetylase inhibitors. Biores Open Access. 2012 Aug;1 (4): 192–8. doi: 10.1089/biores.2012.0223.
14. Venza I., Visalli M., Oteri R., Teti D., Venza M. Class I-specific histone deacetylase inhibitor MS-275 overrides TRAIL-resistance in melanoma cells by downregulating c-FLIP. Int Immunopharmacol. 2014 Aug; 21 (2): 439–46. doi: 10.1016/j.intimp.2014.05.024.
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For citations:
Kayukova E.V., Belokrinitskaya T.E., Kayukova T.V., Khyshiktuev B.S. PATHOGENIC AND CORRELATIVE RELATIONSHIP BETWEEN THE LEVEL OF SHORT- CHAIN FATTY ACIDS AND THE INTENSITY OF BIOLOGICAL PROCESS IN CERVICAL CANCER CELLS DURING CANCEROGENESIS. Siberian journal of oncology. 2018;17(1):32-37. (In Russ.) https://doi.org/10.21294/1814-4861-2018-17-1-32-37
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