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ВОЗМОЖНОСТИ ПРИМЕНЕНИЯ ХОЛОДНОЙ АТМОСФЕРНОЙ ПЛАЗМЫ В ОНКОЛОГИИ (ОБЗОР ЛИТЕРАТУРЫ)

https://doi.org/10.21294/1814-4861-2018-17-1-72-81

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Аннотация

Лучевая и фотодинамическая терапия, используемые при противоопухолевом лечении, генерируют только активные формы кислорода. Вместе с тем было показано, что высокие концентрации NO индуцируют апоптоз опухолевых клеток, предполагая, что азотзависимый стресс может быть одним из решающих факторов в противоопухолевой терапии. Холодная атмосферная плазма (CAP) представляет собой высокореактивное ионизированное физическое состояние, которое вызывает различные биологические эффекты. Процессы ионизации, диссоциации, возбуждения и рекомбинации атомов и молекул в низкотемпературной плазме (НТП) приводят к образованию большого количества активных форм кислорода и азота. В обзоре представлены результаты исследований, раскрывающих механизм противоопухолевого действия НТП, ее воздействие на различные клеточные линии опухолей, описаны результаты лечения опухолей на моделях животных. Высказываются предложения по применению НТП в терапии злокачественных новообразований.

Об авторе

В. Н. Короткий
ФГБУ ВПО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России
Россия

Короткий Владимир Николаевич - кандидат медицинских наук, доцент кафедры дерматовенерологии.

117997, Москва, ул. Островитянова, 1



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Для цитирования:


Короткий В.Н. ВОЗМОЖНОСТИ ПРИМЕНЕНИЯ ХОЛОДНОЙ АТМОСФЕРНОЙ ПЛАЗМЫ В ОНКОЛОГИИ (ОБЗОР ЛИТЕРАТУРЫ). Сибирский онкологический журнал. 2018;17(1):72-81. https://doi.org/10.21294/1814-4861-2018-17-1-72-81

For citation:


Korotky V.N. FEASIBILITY OF USING COLD ATMOSPHERIC PLASMA IN THE TREATMENT OF CANCER PATIENTS (LITERATURE REVIEW). Siberian journal of oncology. 2018;17(1):72-81. (In Russ.) https://doi.org/10.21294/1814-4861-2018-17-1-72-81

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