DETECTION OF SENTINEL LYMPH NODES IN ORGAN-PRESERVING TREATMENT FOR INVASIVE CERVICAL CANCER
https://doi.org/10.21294/1814-4861-2018-17-1-82-91
Abstract
For early stages of cervical cancer, minimally invasive surgery leads to more beneficial outcomes compared to results of more extensive surgery. In this connection, the studies that focus on the assessment of the efficacy of organ-preserving and functionally-sparing approaches to surgical treatment of cervical cancer are of great significance. Sentinel lymph node (SLN) biopsy is the preferred method for assessing pelvic nodal basin status in patients with early stage cervical cancer. The concept of sentinel lymph nodes is especially relevant in cases where the status of lymph nodes is the most important factor in the expediency of performing organ-preserving or adjuvant treatment. The review highlights the problems of the clinical significance of SLN biopsy in detection of metastases that could not be detected using traditional techniques. The diagnostic effectiveness of various routes of tracer injection for SLN visualization was assessed. The comparative results of the use of radiopharmaceuticals used either alone or in combination with blue dye for identification of SLNs were shown. The innovative technique for SLN detection were presented.
About the Authors
A. L. Chernyshova
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
Russian Federation
Alyena L. Chernyshova - MD, DSc, Leading Researcher, Department of Gynecology with the Group of Cancer Prevention, Author ID Scopus: 55220758100, Reseacher ID: C-8608-2012, SPIN-code: 2522-7513.
5, Kooperativny Str., 634009-TomskL. A. Kolomiets
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences; Siberian State Medical University
Russian Federation
Russian Federation
Larisa A. Kolomiets - MD, DSc, Professor, Head of Department of Gynecology with the Group of Cancer Prevention CRITNRMC RAS; Profossor of Oncology Department SState MU, Author ID: 7004921120, Reseacher ID: C-8573-2012.
5, Kooperativny Str., 634009-Tomsk; 2, Moskovsky Tract, 634050-Tomsk
B. I. Chernov
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
Russian Federation
Vladimir I. Chernov - MD, DSc, Professor, Deputy Director for Science and Innovation, Head of Nuclear Medicine Department, Researcher ID: B-6789-2016, Author ID: 7201429550, SPIN-code: 6301-3612.
5, Kooperativny Str., 634009-Tomsk
I. G. Sinilkin
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
Russian Federation
Russian Federation
Ivan G. Sinilkin - MD, PhD, Senior Researcher, Nuclear Medicine Department, Scopus ID: 6506263379. Researcher ID: C-9282-2012, SPIN-code: 7254-3474.
5, Kooperativny Str., 634009-TomskReferences
1. Afanasyev S.G., Avgustinovich A.V., Chernov V.I., Sinilkin I.G. The possibility of identifying sentinel lymph nodes in patients with gastric cancer. Siberian Journal of Oncology. 2009; 4: 27–31. [in Russian]
2. How J., Gotlieb W.H., Press J.Z., Abitbol J., Pelmus M., Ferenczy A., Probst S., Gotlieb R., Brin S., Lau S. Comparing indocyanine green, technetium, and blue dye for sentinel lymph node mapping in endometrial cancer. Gynecol Oncol. 2015 Jun; 137 (3): 436–42. doi: 10.1016/j.ygyno.2015.04.004.
3. Jewell E.L., Huang J.J., Abu-Rustum N.R., Gardner G.J., Brown C.L., Sonoda Y., Barakat R.R., Levine D.A., Leitao M.M.Jr. Detection of sentinel lymph nodes in minimally invasive surgery using indocyanine green and near-infrared fluorescence imaging for uterine and cervical malignancies. Gynecol Oncol. 2014 May; 133 (2): 274–7. doi: 10.1016/j.ygyno.2014.02.028.
4. Baggish M.S., Karram M.K. Atlas of pelvic anatomy and gynecological surgery. London: Elsevier Ltd., 2009. 1172. [in Russian]
5. Höckel M., Horn L.C., Tetsch E., Einenkel J. Pattern analysis of regional spread and therapeutic lymph node dissection in cervical cancer based on ontogenetic anatomy. Gynecol Oncol. 2012 Apr; 125 (1): 168–74. doi: 10.1016/j.ygyno.2011.12.419.
6. Katki H.A., Kinney W.K., Fetterman B., Lorey T., Poitras N.E., Cheung L., Demuth F., Schiffman M., Wacholder S., Castle P.E. Cervical cancer risk for women undergoing concurrent testing for human papillomavirus and cervical cytology: a population-based study in routine clinical practice. Lancet Oncol. 2011 Jul; 12 (7): 663–72. doi: 10.1016/S1470-2045(11)70145-0.
7. Mersin H., Yildirim E., Bulut H., Berberoğlu U. The prognostic significance of total lymph node number in patients with axillary lymph nodenegative breast cancer. Eur J Surg Oncol. 2003 Mar; 29 (2): 132–8.
8. Vorobyeva L.I. Methods of carrying out lymphoscintigraphy. Saint Petersburg, 2010; 23. [in Russian]
9. Oda Y., Todo Y., Hanley S., Hosaka M., Takeda M., Watari H., Kaneuchi M., Kudo M., Sakuragi N. Risk factors for persistent low Bladder Compliance After Radical Hysterectomy. Int J Gynecol Cancer. 2011 Jan; 21 (1): 167–72. doi: 10.1097/IGC.0b013e318204c3df.
10. Yunusova N.V., Kondakova I.V., Kolomiets L.A., Afanasiev S.G., Chernyshova A.L., Shatokhina O.V., Frolova A.E., Zhou Z., Wang W. Serum adipokines and their receptors in endometrial and colon cancer patients: Relationship with tumor invasion and metastasis. Vopr Onkol. 2015; 61 (4): 619–23.
11. Kadkhodayan S., Hasanzadeh M., Treglia G., Azad A., Yousefi Z., Zarifmahmoudi L., Sadeghi R. Sentinel node biopsy for lymph nodal staging of uterine cervix cancer: A systematic review and meta-analysis of the pertinent literature. Eur J Surg Oncol. 2015 Jan; 41 (1): 1–20. doi: 10.1016/j.ejso.2014.09.010.
12. Niikura H., Okamoto S., Otsuki T., Yoshinaga K., Utsunomiya H., Nagase S., Takano T., Ito K., Watanabe M., Yaegashi N. Prospective Study of Sentinel Lymph Node Biopsy Without Further Pelvic Lymphadenectomy in Patients With Sentinel Lymph Node–Negative Cervical Cancer. Int J Gynecol Cancer. 2012 Sep; 22 (7): 1244–50. doi: 10.1097/IGC.0b013e318263f06a.
13. Yamashita T., Katayama H., Kato Y., Nishiwaki K., Hayashi H., Miyokawa N., Sengoku K. Management of pelvic lymph nodes by sentinel node navigation surgery in the treatment of invasive cervical cancer. Int J Gynecol Cancer. 2009 Aug; 19 (6): 1113–8. doi: 10.1111/IGC.0b013e3181a83d65.
14. Noyes N., Knopman J.M., Long K., Coletta J.M., Abu-Rustum N.R. Fertility considerations in the management of gynecologic malignancies. Gynecol Oncol. 2011 Mar; 120 (3): 326–33. doi: 10.1016/j.ygyno.2010.09.012.
15. Dabbagh Kakhki V.R., Jangjoo A., Tavassoli A., Asadi M., Sadri K., Fatahi Masoom A., Sadeghi R. Sentinel node mapping for early breast cancer patients using 99mTc-phytate: Single center experience on 165 patients. J Nucl Med. 2012; 20 (2): 25–29.
16. Lennox G.K., Covens A. Can sentinel lymph node biopsy replace pelvic lymphadenectomy for early cervical cancer? Gynecol Oncol. 2017 Jan; 144 (1): 16–20. doi: 10.1016/j.ygyno.2016.08.337.
17. Mathevet P., Lecuru F., Magaud L., Bouttitie F. Sentinel lymph node biopsy for early cervical cancer: Results of a randomized prospective, multicenter study (Senticol 2) comparing adding pelvic lymph node dissection vs sentinel node biopsy only. Gynecol Oncol. 2017; 145 (1): 2–3.
18. Nishio H., Fujii T., Sugiyama J., Kuji N., Tanaka M., Hamatani T., Miyakoshi K., Minegishi K., Tsuda H., Iwata T., Tanaka K., Fukuchi T., Takehara Y., Yoshimura Y., Aoki D. Reproductive and obstetric outcomes after radical abdominal trachelectomy for early-stage cervical cancer in a series of 31 pregnancies. Hum Reprod. 2013 Jul; 28 (7): 1793–8. doi: 10.1093/humrep/det118.
19. Rob L., Robova H., Halaska M.J., Hruda M., Skapa P. Current status of sentinel lymph node mapping in the management of cervical cancer. Expert Rev Anticancer Ther. 2013 Jul; 13 (7): 861–70. doi: 10.1586/14737140.2013.811147.
20. Chernyshova A.L., Kolomiets L.A., Sinilkin I.G., Chernov V.I., Lyapunov A.Yu. Optimization of the extent of surgery in organ-preserving treatment for invasive cervical cancer (the role of sentinel lymph nodes study). Problems of Onkology. 2016; 62 (6): 807–811. [in Russian]
21. Ohba Y., Todo Y., Kobayashi N., Kaneuchi M., Watari H., Takeda M., Sudo S., Kudo M., Kato H., Sakuragi N. Risk factors for lower-limb lymphedema after surgery for cervical cancer. Int J Clin Oncol. 2011 Jun; 16 (3): 238–43. doi: 10.1007/s10147-010-0171-5.
22. Ionescu S., Bratucu E., Straja N.D., Simion L., Marincas M., Prunoiu V., Chitoran E., Rotaru V., Alecu M., Lazar A.M. Recurrence rates after radical hysterectomy with pelvic lymphadenectomy. Surgical Oncol. 2016; 42 (9): 158.
23. Lu Q., Zhang Y., Wang S., Guo S., Guo H., Zhang Z., Liu C. Neoadjuvant intra-arterial chemotherapy followed by total laparoscopic radical trachelectomy in stage IB1 cervical cancer. Fertil Steril. 2014 Mar; 101 (3): 812–7. doi: 10.1016/j.fertnstert.2013.12.001.
24. Sun L.T., Ning C.P., Liu Y.J., Wang Z.Z., Wang L.D., Kong X.C., Tian J.W. Is transvaginal elastography useful in pre-operative diagnosis of cervical cancer? Eur J Radiol. 2012 Aug; 81 (8): e888–92. doi: 10.1016/j.ejrad.2012.04.025.
25. Varlamova N.V., Skuridin V.S., Nesterov E.A., Chernov V.I., Titskaya A.A. Studying Acute Toxicity of New Radiopharmaceutical 99mTc-Al2O3 Nanocolloids for Oncological Diagnostics. Experimental and Clinical Pharmacology. 2015; 78 (6): 26–29. [in Russian]
26. Ramirez P.T., Pareja R., Rendón G.J., Millan C., Frumovitz M., Schmeler K.M. Management of low-risk early-stage cervical cancer: Should conization, simple trachelectomy, or simple hysterectomy replace radical surgery as the new standard of care? Gynecol Oncol. 2014 Jan; 132 (1): 254–9. doi: 10.1016/j.ygyno.2013.09.004.
27. Yunusova N.V., Spirina L.V., Kondakova I.V., Kolomiets L.A., Chernyshova A.L., Koval V.D., Nedosekov V.V., Savenkova O.V. Relationship between the expression levels of PAPP-A metalloproteinase and growth and transcriptional factors in endometrial cancer. Izv Akad Nauk Ser Biol. 2013 May-Jun; (3): 284–91.
28. Plante M., Gregoire J., Renaud M.C., Roy M. The vaginal radical trachelectomy: an update of series of 125 cases and 106 pregnancies. Gynecol Oncol. 2011 May 1; 121 (2): 290–7. doi: 10.1016/j.ygyno.2010.12.345.
29. Tax C., Rovers M.M., de Graaf C., Zusterzeel P.L., Bekkers R.L. The sentinel node procedure in early stage cervical cancer, taking the next step; a diagnostic review. Gynecol Oncol. 2015 Dec; 139 (3): 559–67. doi: 10.1016/j.ygyno.2015.09.076.
30. Onal C., Guler O.C., Reyhan M., Yapar A.F. Prognostic value of 18F-fluorodeoxyglucose uptake in pelvic lymph nodes in patients with cervical cancer treated with definitive chemoradiotherapy. Gynecol Oncol. 2015 Apr; 137 (1): 40–6. doi: 10.1016/j.ygyno.2015.01.542.
31. Du X.L., Sheng X.G., Jiang T., Li Q.S., Yu H., Pan C.X., Lu C.H., Wang C., Song Q.Q. Sentinel lymph node biopsy as guidance for radical trachelectomy in young patients with early stage cervical cancer. BMC Cancer. 2011 May 2; 11: 157. doi: 10.1186/1471-2407-11-157.
32. Ramirez P.T., Jhingran A., Macapinlac H.A., Euscher E.D., Munsell M.F., Coleman R.L., Soliman P.T., Schmeler K.M., Frumovitz M., Ramondetta L.M. Laparoscopic extraperitoneal para-aortic lymphadenectomy in locally advanced cervical cancer. Cancer. 2011 May 1; 117 (9): 1928–34. doi: 10.1002/cncr.25739.
33. Karakatsanis A., Christiansen P.M., Fischer L., Hedin C., Pistioli L., Sund M., Daskalakis K. The Nordic SentiMag trial: a comparison of super paramagnetic iron oxide (SPIO) nanoparticles versus Tc99 and patent blue in the detection of sentinel node (SN) in patients with breast cancer and a meta-analysis of earlier studies. Breast Cancer Res Treat. 2016; 157 (2): 281–94.
34. Spirina L.V., Bochkareva N.V., Kondakova I.V., Kolomiets L.A., Shashova E.E., Koval’ V.D., Chernysheva A.L., Asadchikova O.N. Regulation of insulin-like growth NF-κB proteasome system in endometrial cancer. Mol Biol (Mosk). 2012 May-Jun; 46 (3): 452–60.
35. Okugawa K., Kobayashi H., Sonoda K., Kaneki E., Kawano Y., Hidaka N., Egashira K., Fujita Y., Yahata H., Kato K. Oncologic and obstetric outcomes and complications during pregnancy after fertility-sparing abdominal trachelectomy for cervical cancer: a retrospective review. Int J Clin Oncol. 2017 Apr; 22 (2): 340–346. doi: 10.1007/s10147-016-1059-9.
36. Plante M. Bulky Early-Stage Cervical Cancer (2-4 cm Lesions): Upfront Radical Trachelectomy or Neoadjuvant Chemotherapy Followed by Fertility-Preserving Surgery: Which Is the Best Option? Int J Gynecol Cancer. 2015 May; 25 (4): 722–8. doi: 10.1097/IGC.0000000000000410.
37. Wuntakal R., Papadopoulos A.J., Montalto S.A., Perovic M., Coutts M., Devaja O. Location of Sentinel Lymph Node in Cervical Carcinoma and Factors Associated With Unilateral Detection. Int J Gynecol Cancer. 2015 Nov; 25 (9): 1663–8. doi: 10.1097/IGC.0000000000000539.
38. Robova H., Rob L., Halaska M.J., Pluta M., Skapa P. Review of Neoadjuvant Chemotherapy and Trachelectomy: Which Cervical Cancer Patients Would Be Suitable for Neoadjuvant Chemotherapy Followed by Fertility-Sparing Surgery? Curr Oncol Rep. 2015; 17 (5): 446. doi: 10.1007/s11912-015-0446-0.
39. Rob L., Robova H., Pluta M., Halaska M.J., Hruda M., Skapa P., Charvat M. Oncologic outcome of less radical surgery versus radical hysterectomy C1 in small early stage I cervical cancer. Gynecol Oncol. 2016; 141 (1): 122.
40. Mangler M., Lanowska M., Köhler C., Vercellino F., Schneider A., Speiser D. Pattern of cancer recurrence in 320 patients after radical vaginal trachelectomy. Int J Gynecol Cancer. 2014 Jan; 24 (1): 130–4. doi: 10.1097/IGC.0000000000000012.
41. Maneo A., Sideri M., Scambia G., Boveri S., Dell’anna T., Villa M., Parma G., Fagotti A., Fanfani F., Landoni F. Simple conization and lymphadenectomy for the conservative treatment of stage IB1 cervical cancer. An Italian experience. Gynecol Oncol. 2011 Dec; 123 (3): 557–60. doi: 10.1016/j.ygyno.2011.08.009.
Review
For citations:
Chernyshova A.L., Kolomiets L.A., Chernov B.I., Sinilkin I.G. DETECTION OF SENTINEL LYMPH NODES IN ORGAN-PRESERVING TREATMENT FOR INVASIVE CERVICAL CANCER. Siberian journal of oncology. 2018;17(1):82-91. (In Russ.) https://doi.org/10.21294/1814-4861-2018-17-1-82-91
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