LONG-TERM TREATMENT RESULTS IN PATIENTS WITH LOCALLY ADVANCED COLON CANCER
Abstract
The rate of colon cancer recurrence after primary radical resection is reported to be 20–30%. Treatment approaches for patients with locally recurrent colon cancer are widely discussed in the literature. The retrospective analysis included 265 patients with stage I–III primary colon cancer treated at the Moscow Cancer Center from 2004 to 2008. In patients with locally recurrent colon cancer who underwent radical surgery, the median survival time was 34.3 months. In patients who underwent palliative surgery, the median survival time was 21.8 months and in patients who received chemotherapy, the median survival time was 12.0 months. The overall survival rate in patients with local recurrence of colon cancer was found to be increased after radical surgery with or without chemotherapy.
About the Authors
A. V. Butenko
Moscow P.A. Gertsen Research Institute of Oncology, Moscow
Russian Federation
Russian Federation
A. A. Sokolov
Moscow Municipal Cancer Hospital № 62
Russian Federation
Russian Federation
S. A. Privezentsev
Moscow Municipal Cancer Hospital № 62
Russian Federation
Russian Federation
V. M. Akhmetshina
Moscow Municipal Cancer Hospital № 62
Russian Federation
Russian Federation
References
1. Беляева А.В., Моисеенко А.Б., Гуляев А.В. Современные представления о прогностических факторах колоректального рака // Вопросы онкологии. 2011. Т. 57, № 3. C. 279–285.
2. Дворниченко В.В., Афанасьев С.Г., Шелехов А.В., Москвина Н.А. Лучевая терапия в комбинированном лечении рака прямой кишки (обзор литературы) // Сибирский онкологический журнал. 2009. № 1 (31). С. 72–77.
3. Чиссов В.И., Старинский В.В., Петрова Г.В. Злокачественные новообразования в России в 2010 году (заболеваемость и смертность). M.: МНИОИ им. П.А. Герцена Росмедтехнологий, 2011. 256 с.
4. Abulafi A.M., Williams N.S. Local recurrence of colorectal cancer: the problem, mechanisms, management and adjuvant therapy // Br. J. Surg. 1994. Vol. 81 (1). P. 7–19.
5. Bowne W.B., Lee B., Wong W.D. et al. Operative salvage for locoregional recurrent colon cancer after curative resection: an analysis of 100 cases // Dis. Colon Rectum. 2005. Vol. 48 (5). P. 897–909.
6. Ferlay J., Shin H.R., Bray F. et al. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008 // Int. J. Cancer. 2010. Vol. 127 (12). P. 2893–2917.
7. Hellinger M.D., Santiago C.A. Reoperation for recurrent colorectal cancer // Clin. Colon Rectal Surg. 2006. Vol. 19 (4). P. 228–236.
8. Mirnezami A.H., Sagar P.M., Kavanagh D. et al. Clinical algorithms for the surgical management of locally recurrent rectal cancer // Dis. Colon Rectum. 2010. Vol. 53 (9). P. 1248–1257.
9. O’Connell M.J., Campbell M.E., Goldberg R.M. et al. Survival following recurrence in stage II and III colon cancer: findings from the ACCENT data set // J. Clin. Oncol. 2008. Vol. 26 (14). P. 2336–2341.
10. Prochotsky A., Okolicany R., Sekac J., Skultety J. Diagnosis and management of local and locoregional recurrence of colorectal carcinoma // Bratisl Lek Listy. 2009. Vol. 110 (9). P. 569–573.
11. Sugarbaker P.H. Revised guidelines for second-look surgery in patients with colon and rectal cancer // Clin. Transl. Oncol. 2010. Vol 12 (9). P. 621–628.
12. Taylor W.E., Donohue J.H., Gunderson L.L. et al. The Mayo Clinic experience with multimodality treatment of locally advanced or recurrent colon cancer // Ann. Surg. Oncol. 2002. Vol. 9 (2). P. 177–185.
13. Vermaas M., Ferenschild F.T., Verhoef C. et al. Total pelvic exenteration for primary locally advanced and locally recurrent rectal cancer // Eur. J. Surg. Oncol. 2007. Vol. 33 (4). P. 452–458.
Review
For citations:
Butenko A.V., Sokolov A.A., Privezentsev S.A., Akhmetshina V.M. LONG-TERM TREATMENT RESULTS IN PATIENTS WITH LOCALLY ADVANCED COLON CANCER. Siberian journal of oncology. 2013;(2):25-29. (In Russ.)
Views:
563
Email this article 
