METASTATIC MULTIPLE PRIMARY GASTROINTESTINAL MELANOMA: A CASE REPORT
https://doi.org/10.21294/1814-4861-2020-19-6-155-160
Abstract
Primary gastrointestinal melanoma is a rare tumor with a frequency of 1 new case per 5–7 years. Over the past 100 years, there have been no more than 25 reported cases of primary melanoma of the stomach and colon. The rarity of the disease and nonspecific clinical features pose diagnostic challenges. The tumor is characterized by an aggressive growth and early metastasis. Case description. We present a rare clinical case of primary gastrointestinal melanoma with metastatic involvement of the adrenal glands, liver and retroperitoneal lymph nodes. Conclusion. To date, treatment standards for primary gastrointestinal melanoma have not been developed and are the subject of debate. However, palliative chemotherapy used for the treatment of primary skin melanoma may lead to disease stabilization in patients with gastrointestinal melanoma.
About the Authors
D. N. KostromitskyRussian Federation
MD, PhD, Junior Researcher, Department of Abdominal Oncology; Physician
5, Kooperativny per., 634009, Tomsk, Russia
115, Lenina Prospekt, 634050, Tomsk, Russia
A. Yu. Dobrodeev
Russian Federation
MD, DSc, Leading Researcher, Department of Abdominal Oncology
Researcher ID (WOS): B-5644-2017. Author ID (Scopus): 24832974200
5, Kooperativny per., 634009, Tomsk, Russia
S. G. Afanasyev
Russian Federation
MD, DSc, Professor, Head of the Department of Abdominal Oncology
Researcher ID (WOS): D-2084-2012. Author ID (Scopus): 21333316900
5, Kooperativny per., 634009, Tomsk, Russia
N. A. Li
Russian Federation
MD, Head of Intraluminal Endoscopic Diagnostic Department
115, Lenina Prospekt, 634050, Tomsk, Russia
N. V. Vasilyev
Russian Federation
MD, PhD, Pathologist, Department of General and Molecular Pathology
Researcher ID (WOS): D-1144-2012. Author ID (Scopus): 57192110276
5, Kooperativny per., 634009, Tomsk, Russia
A. S. Podyablonsky
Russian Federation
MD, Roentgenologist, MRI Department
115, Lenina Prospekt, 634050, Tomsk, Russia
References
1. Khaliq A., Siddappa P.K., Thandassery R.B., Kochhar R., Bhattacharya A., Vaiphei K., Singh K. Melanoma of stomach. J Gastrointest Cancer. 2012 Dec; 43(4): 630–3. doi: 10.1007/s12029-011-9342-5.
2. Li H., Fan Q., Wang Z., Xu H., Li X., Zhang W., Zhang Z. Primary malignant melanoma of the duodenum without visible melanin pigment: a mimicker of lymphoma or carcinoma. Diagn Pathol. 2012 Jun 26; 7: 74. doi: 10.1186/1746-1596-7-74.
3. Titov K.S., Dolgopyatov I.A., Askerova Z.M., Atroshсhenko A.O. Gastro-intestinal melanoma (review). Coloproctology. 2017; (2): 94–99. (in Russian).
4. Ahn J.Y., Hwang H.S., Park Y.S., Kim H.R., Jung H.Y., Kim J.H., Lee S.E., Kim M.A. Endoscopic and pathologic findings associated with clinical outcomes of melanoma in the upper gastrointestinal tract. Ann Surg Oncol. 2014; 21(8): 2532–9. doi: 10.1245/s10434-014-3637-2.
5. Blecker D., Abraham S., Furth E.E., Kochman M.L. Melanoma in the gastrointestinal tract. Am J Gastroenterol. 1999 Dec; 94(12): 3427–33. doi: 10.1111/j.1572-0241.1999.01604.x.
6. Kottschade L.A., Grotz T.E., Dronca R.S., Salomao D.R., Pulido J.S., Wasif N., Jakub J.W., Bagaria S.P., Kumar R., Kaur J.S., Morita S.Y., Moran S.L., Nguyen J.T., Nguyen E.C., Hand J.L., Erickson L.A., Brewer J.D., Baum C.L., Miller R.C., Swanson D.L., Lowe V., Markovic S.N. Rare presentations of primary melanoma and special populations: a systematic review. Am J Clin Oncol. 2014 Dec; 37(6): 635–41. doi: 10.1097/COC.0b013e3182868e82.
7. Idir B.A., Riany A., Jahid A., Chad B. Primary melanoma of the small bowel revealed by gastrointestinal bleeding: a case report. J Med Case Rep. 2016 Dec 1; 10(1): 335. doi: 10.1186/s13256-016-1119-9.
8. Deutsch G.B., Flaherty D.C., Kirchoff D.D., Bailey M., Vitug S., Foshag L.J., Faries M.B., Bilchik A.J. Association of Surgical Treatment, systemic therapy, and survival in patients with abdominal visceral melanoma metastases, 1965-2014: relevance of surgical cure in the era of modern systemic therapy. JAMA Surg. 2017 Jul 1; 152(7): 672–678. doi: 10.1001/jamasurg.2017.0459.
9. Sachs D.L., Lowe L., Chang A.E., Carson E., Johnson T.M. Do primary small intestinal melanomas exist Report of a case. J Am Acad Dermatol. 1999; 41: 1042–44. doi: https://doi.org/10.1016/S0190-9622 (99) 70273-2.
10. Giannini I., Cutrignelli D.A., Resta L., Gentile A., Vincenti L. Metastatic melanoma of the gallbladder: report of two cases and a review of the literature. Clin Exp Med. 2016 Aug; 16(3): 295–300. doi: 10.1007/s10238-015-0353-6.
11. Shustef E., Torres-Cabala C.A., Curry J.L., Tetzlaff M.T., Nagarajan P., Ivan D., Prieto V.G., Aung P.P. Intraepithelial melanoma in the stomach after treatment with immune checkpoint blockade therapy. Am J Dermatopathol. 2017 Aug; 39(8): e116e118. doi: 10.1097/DAD.0000000000000859.
12. Baur E.H. Ein Fall von primarem melanom des esophagus. Arb Geb Pathol Anat Inst Tubingen. 1906; 5: 343–354.
13. Tacastacas J.D.,BrayJ., CohenY.K., ArbesmanJ., KimJ., KoonH.B., Honda K., Cooper K.D., Gerstenblith M.R. Update on primary mucosal melanoma. J Am Acad Dermatol. 2014 Aug; 71(2): 366–75. doi: 10.1016/j.jaad.2014.03.031.
14. Wang L., Zong L., Nakazato H., Wang W.-Y., Li C.-F., Shi Y.-F., Zhang G.-C., Tang T. Primary advanced esophago-gastric melanoma: A rare case. World J Gastroenterol. 2016 Mar; 22(11): 3296–301. doi: 10.3748/wjg.v22.i11.3296.
15. Toneev Е.A., Charyshkin A.L., Dengina N.V., Zhinov A.V., Martynov A.A., Gordonov S.V., Lazarevskiy M.M. A c ase of p rimary gastric melanoma. Malignant Tumours. 2020; 10(1): 35–40. (in Russian). doi: 10.18027/2224-5057-2020-10-35-40.
Review
For citations:
Kostromitsky D.N., Dobrodeev A.Yu., Afanasyev S.G., Li N.A., Vasilyev N.V., Podyablonsky A.S. METASTATIC MULTIPLE PRIMARY GASTROINTESTINAL MELANOMA: A CASE REPORT. Siberian journal of oncology. 2020;19(6):155-160. (In Russ.) https://doi.org/10.21294/1814-4861-2020-19-6-155-160