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MOLECULAR-GENETIC MARKERS OF RESPONSE TO NEOADJUVANT CHEMOTHERAPY WITH ANTHRACYCLINES IN BREAST CANCER PATIENTS

https://doi.org/10.21294/1814-4861-2016-15-2-29-35

Abstract

The purpose of the study: to evaluate the response to neoadjuvant anthracycline-based chemotherapy depending on the presence of deletions and amplifications of different chromosomal loci and the expression level of topoisomerase 2а in tumor tissue of breast cancer patients. Materials and methods. The study included 46 patients with stage T2–4N0–3M0 breast cancer, who received 2–6 cycles of neoadjuvant chemotherapy with FAC and CAX regimens. Results. The relationship between the expression level of Тор2а>5, deletions of ABCB1, ABCB3, 18р11.21, 11q22.1 loci and amplification of 1q24.1-43 and the response to preoperative treatment was found. Of the 34 patients having at least one of these markers in the tumor tissue, 85.3 % of them demonstrated partial response to neoadjuvant chemotherapy (> 50 % reduction of tumor) and 14.7 % had stable disease and disease progression. No above markers were found in the tumor tissue of 12 patients, who did not respond to preoperative treatment. Conclusion. High levels of Тор2а>5 expression, deletions of ABCB1; ABCB3; 18р11.21; 11q22.1 loci and 1q24.1-43 amplification were shown to be predictive markers of response to neoadjuvant anthracycline-based chemotherapy. The presence of at least one of these markers allowed us to predict response to preoperative treatment in 85 % of cases.

About the Authors

P. V. Kazantseva
Tomsk Cancer Research Institute, 5, Kooperativny per., 634009-Tomsk;
Russian Federation

Postgraduate student, Department of General Oncology. Tomsk Cancer Research Institute (Tomsk, Russian Federation). SPIN-code: 7881-6259.



М. М. Tsyganov
Tomsk Cancer Research Institute, 5, Kooperativny per., 634009-Tomsk; National Research Tomsk State University, Tomsk
Russian Federation

Junior Research, Laboratory of Viral Oncology, Tomsk Cancer Research Institute (Tomsk, Russian Federation). SPIN-code: 1253-0240.



Е. М. Slonimskaya
Siberian State Medical University, Tomsk
Russian Federation

MD, DSc Professor, Head of General Oncology Department, Tomsk Cancer Research Institute (Tomsk, Russian Federation). SPIN-code: 7763-6417.



N. V. Litvyakov
Tomsk Cancer Research Institute, 5, Kooperativny per., 634009-Tomsk; National Research Tomsk State University, Tomsk
Russian Federation

DSc, Head of Laboratory of Viral Oncology, Tomsk Cancer Research Institute (Tomsk, Russian Federation). SPIN-code: 2546-0181.



Н. В. Cherdyntseva
Tomsk Cancer Research Institute, 5, Kooperativny per., 634009-Tomsk;
Russian Federation

DSc Professor, Deputy Director for Basic Science, Head of Laboratory of Molecular Oncology and Immunology, Tomsk Cancer Research Institute (Tomsk, Russian Federation). SPIN-code: 5344-0990.



М. K. Ibragimova
Tomsk Cancer Research Institute, 5, Kooperativny per., 634009-Tomsk; National Research Tomsk State University, Tomsk
Russian Federation

Junior Research, Laboratory of Viral Oncology, Tomsk Cancer Research Institute (Tomsk, Russian Federation). SPIN-code: 2340-1628.



А. V. Doroshenko
Tomsk Cancer Research Institute, 5, Kooperativny per., 634009-Tomsk;
Russian Federation

MD, PhD Researcher, Department of General Oncology Tomsk Cancer Research Institute (Tomsk, Russian Federation). SPIN-code: 7874-7606.



N. А. Tarabanovskaya
Tomsk Cancer Research Institute, 5, Kooperativny per., 634009-Tomsk;
Russian Federation

MD, PhD Junior Research, Department of General Oncology, Tomsk Cancer Research Institute (Tomsk,Russian Federation). SPINcode: 7481-2159.



S. V. Patalyak
Tomsk Cancer Research Institute, 5, Kooperativny per., 634009-Tomsk;
Russian Federation

MD, PhD Junior Research, Department of General Oncology, Tomsk Cancer Research Institute (Tomsk, Russian Federation). SPIN-code: 8497-1750.



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For citations:


Kazantseva P.V., Tsyganov М.М., Slonimskaya Е.М., Litvyakov N.V., Cherdyntseva Н.В., Ibragimova М.K., Doroshenko А.V., Tarabanovskaya N.А., Patalyak S.V. MOLECULAR-GENETIC MARKERS OF RESPONSE TO NEOADJUVANT CHEMOTHERAPY WITH ANTHRACYCLINES IN BREAST CANCER PATIENTS. Siberian journal of oncology. 2016;15(2):29-35. (In Russ.) https://doi.org/10.21294/1814-4861-2016-15-2-29-35

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ISSN 1814-4861 (Print)
ISSN 2312-3168 (Online)