Concurrent incidence of esophageal squamous cell carcinoma and gastric adenocarcinoma: a report of three cases

E. A. Toneev; N. V. Dengina; D. V. Glumnushina; R. R. Valeeva; M. S. Rudenko; A. A. Martynov; E. P. Anokhina; A. M. Ponomarenko

doi:10.21294/1814-4861-2025-24-5-180-189

Concurrent incidence of esophageal squamous cell carcinoma and gastric adenocarcinoma: a report of three cases

E. A. Toneev, N. V. Dengina, D. V. Glumnushina, R. R. Valeeva, M. S. Rudenko, A. A. Martynov, E. P. Anokhina, A. M. Ponomarenko

https://doi.org/10.21294/1814-4861-2025-24-5-180-189

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Abstract

The purpose of the study was to investigate rare cases of concurrent incidence of esophageal squamous cell carcinoma and gastric adenocarcinoma to develop an effective treatment strategy.

Material and Methods. Herein, we present a report of three cases of simultaneous occurrence of esophageal squamous cell carcinoma and gastric adenocarcinoma treated at the Regional Clinical Oncology Center in Ulyanovsk and Sverdlovsk Regional Oncology Center in Yekaterinburg. The patients underwent surgery, chemotherapy and radiation therapy.

Results. Synchronous esophageal squamous cell carcinoma and gastric adenocarcinoma pose significant treatment challenges, necessitating a multidisciplinary team of specialists. Chemoradiotherapy with the FOLFOX regimen demonstrated favorable tolerability and satisfactory clinical response.

Conclusion. A multimodal approach, involving surgery and chemoradiotherapy with the FOLFOX scheme, may be a valuable option for the treatment of patients with synchronous esophageal squamous cell carcinoma and gastric adenocarcinoma.

Keywords

squamous cell carcinoma of the esophagus, gastric adenocarcinoma, treatment of esophageal and gastric cancers, chemoradiotherapy of esophageal cancer, FOlFOX

About the Authors

E. A. Toneev

Regional Clinical Oncology Center; Ulyanovsk State University
Russian Federation

Evgeny A. Toneev - MD, PhD, Thoracic Surgeon, Surgical Department of Thoracic Oncology, Regional Clinical Oncology Center; Associate Professor, Department of Faculty Surgery, T.Z. Biktimirov Medical Faculty, Institute of Medicine, Ecology and Physical Culture, USU.

90, 12 September St., Ulyanovsk, 432017; 42, Lva Tolstogo St., Ulyanovsk, 432017

N. V. Dengina

Regional Clinical Oncology Center
Russian Federation

Natalia V. Dengina - MD, PhD, Head of the Radiological Department.

90, 12 September St., Ulyanovsk, 432017

D. V. Glumnushina

Ulyanovsk State University
Russian Federation

Darya V. Glumnushina - student, T.Z. Biktimirov Faculty of Medicine, Institute of Medicine, Ecology and Physical Culture.

42, Lva Tolstogo St., Ulyanovsk, 432017

R. R. Valeeva

Ulyanovsk State University
Russian Federation

Rania R. Valeeva - student, T.Z. Biktimirov Faculty of Medicine, Institute of Medicine, Ecology and Physical Culture.

42, Lva Tolstogo St., Ulyanovsk, 432017

M. S. Rudenko

Sverdlovsk Regional Oncology Center
Russian Federation

Maxim S. Rudenko - MD, Head of the Thoracic Oncology Department, Sverdlovsk Regional Oncology Center; Assistant, Department of Oncology and Diagnostic Imaging of Higher Education.

29, Soboleva St., Ekaterinburg, 620036

A. A. Martynov

Regional Clinical Oncology Center
Russian Federation

Alexander A. Martynov - MD, Head of the Surgical Thoracic Department.

90, 12 September St., Ulyanovsk, 432017

E. P. Anokhina

Regional Clinical Oncology Center
Russian Federation

Ekaterina P. Anokhina - MD, Oncologist, Department of Chemotherapy No. 1.

90, 12 September St., Ulyanovsk, 432017

A. M. Ponomarenko

Regional Clinical Oncology Center
Russian Federation

Anna M. Ponomarenko - MD, Radiologist, X-ray Department.

90, 12 September St., Ulyanovsk, 432017

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Supplementary files

	1. Fig. 1. Chest CT scans performed before treatment (sagittal plane, soft tissue window, slice thickness of 1.0 mm) with contrast enhancement demonstrate uneven thickening of the walls of the middle third of the esophagus (48 mm long), narrowing of the esophageal lumen, and enlargement of paraesophageal lymph nodes to 13x15 mm. Note: created by the authors
	Subject
	Type	Исследовательские инструменты
	View (378KB)	Indexing metadata ▾

	2. Fig. 2. Abdominal CT scans (axial plane, soft tissue window, 1.2 mm slice thickness) in the portal phase reveal an uneven semicircular thickening of the walls of the lower third of the body and the antrum of the stomach in an area extending up to 63 mm with signs of pathological accumulation of contrast agent. Note: created by the authors
	Subject
	Type	Исследовательские инструменты
	View (397KB)	Indexing metadata ▾

	3. Fig. 3. Abdominal CT scans before treatment (axial plane, soft tissue window, 1.2 mm slice thickness), in the portal phase, show that in the area of the previously described tumor, the walls are not thickened, no additional lesions are detected. Note: created by the authors
	Subject
	Type	Исследовательские инструменты
	View (440KB)	Indexing metadata ▾

	4. Fig. 4. Contrast-enhanced chest CT scans (sagittal plane, soft tissue window, 1.2mm slice thickness) after chemoradiation therapy show that the wall thickness and potential narrowing are no longer present. Note: created by the authors
	Subject
	Type	Исследовательские инструменты
	View (527KB)	Indexing metadata ▾

	5. Fig. 5. Chest CT scans before treatment (sagittal plane, soft tissue window, 2.6 mm slice thickness) in the portal phase reveal an uneven thickening of the wall of the middle third of the esophagus with signs of pathological accumulation of contrast agent, pathologically altered lymph nodes in the adjacent tissue. Note: created by the authors
	Subject
	Type	Исследовательские инструменты
	View (298KB)	Indexing metadata ▾

	6. Fig. 6. Abdominal CT scans before treatment (axial plane, soft tissue window, 2.5 mm slice thickness), in the portal phase show that in the structure of the stomach wall along the lesser curvature, there is an area of wall thickening due to a lesion extending beyond the serous membrane into the adjacent tissue, accumulation of the contrast agent. Note: created by the authors
	Subject
	Type	Исследовательские инструменты
	View (233KB)	Indexing metadata ▾

	7. Fig. 7. Chest CT scans (sagittal plane, soft tissue window, 1.2 mm slice thickness) in the portal phase after chemoradiotherapy show no change in the site of the previously revealed thickening of the walls of the middle third of the esophagus (compared with other sites); no areas of pathological accumulation of contrast agent are seen. Note: created by the authors
	Subject
	Type	Исследовательские инструменты
	View (117KB)	Indexing metadata ▾

	8. Fig. 8. Abdominal CT scans (axial plane, soft tissue window, slice thickness 1.2 mm), in the portal phase after chemoradiotherapy show no additional lesions in the structure of the stomach wall along the lesser curvature; no signs of pathological accumulation of contrast agent are not seen. Note: created by the authors
	Subject
	Type	Исследовательские инструменты
	View (107KB)	Indexing metadata ▾

	9. Fig. 9. Contrast-enhanced chest CT scans (sagittal plane, soft tissue window, 1.0 mm slice thickness) reveal an uneven thickening of the walls of the middle third of the esophagus in a 52 mm long, the lumen of the esophagus is narrowed, fragmentary. Note: created by the authors
	Subject
	Type	Исследовательские инструменты
	View (462KB)	Indexing metadata ▾

Review

For citations:

Toneev E.A., Dengina N.V., Glumnushina D.V., Valeeva R.R., Rudenko M.S., Martynov A.A., Anokhina E.P., Ponomarenko A.M. Concurrent incidence of esophageal squamous cell carcinoma and gastric adenocarcinoma: a report of three cases. Siberian journal of oncology. 2025;24(5):180-189. (In Russ.) https://doi.org/10.21294/1814-4861-2025-24-5-180-189

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ISSN 1814-4861 (Print)
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	Title	Fig. 1. Chest CT scans performed before treatment (sagittal plane, soft tissue window, slice thickness of 1.0 mm) with contrast enhancement demonstrate uneven thickening of the walls of the middle third of the esophagus (48 mm long), narrowing of the esophageal lumen, and enlargement of paraesophageal lymph nodes to 13x15 mm. Note: created by the authors
	Type	Исследовательские инструменты
	Date	2025-12-02

	Title	Fig. 2. Abdominal CT scans (axial plane, soft tissue window, 1.2 mm slice thickness) in the portal phase reveal an uneven semicircular thickening of the walls of the lower third of the body and the antrum of the stomach in an area extending up to 63 mm with signs of pathological accumulation of contrast agent. Note: created by the authors
	Type	Исследовательские инструменты
	Date	2025-12-02

	Title	Fig. 3. Abdominal CT scans before treatment (axial plane, soft tissue window, 1.2 mm slice thickness), in the portal phase, show that in the area of the previously described tumor, the walls are not thickened, no additional lesions are detected. Note: created by the authors
	Type	Исследовательские инструменты
	Date	2025-12-02

	Title	Fig. 4. Contrast-enhanced chest CT scans (sagittal plane, soft tissue window, 1.2mm slice thickness) after chemoradiation therapy show that the wall thickness and potential narrowing are no longer present. Note: created by the authors
	Type	Исследовательские инструменты
	Date	2025-12-02

	Title	Fig. 5. Chest CT scans before treatment (sagittal plane, soft tissue window, 2.6 mm slice thickness) in the portal phase reveal an uneven thickening of the wall of the middle third of the esophagus with signs of pathological accumulation of contrast agent, pathologically altered lymph nodes in the adjacent tissue. Note: created by the authors
	Type	Исследовательские инструменты
	Date	2025-12-02

	Title	Fig. 6. Abdominal CT scans before treatment (axial plane, soft tissue window, 2.5 mm slice thickness), in the portal phase show that in the structure of the stomach wall along the lesser curvature, there is an area of wall thickening due to a lesion extending beyond the serous membrane into the adjacent tissue, accumulation of the contrast agent. Note: created by the authors
	Type	Исследовательские инструменты
	Date	2025-12-02

	Title	Fig. 7. Chest CT scans (sagittal plane, soft tissue window, 1.2 mm slice thickness) in the portal phase after chemoradiotherapy show no change in the site of the previously revealed thickening of the walls of the middle third of the esophagus (compared with other sites); no areas of pathological accumulation of contrast agent are seen. Note: created by the authors
	Type	Исследовательские инструменты
	Date	2025-12-02

	Title	Fig. 8. Abdominal CT scans (axial plane, soft tissue window, slice thickness 1.2 mm), in the portal phase after chemoradiotherapy show no additional lesions in the structure of the stomach wall along the lesser curvature; no signs of pathological accumulation of contrast agent are not seen. Note: created by the authors
	Type	Исследовательские инструменты
	Date	2025-12-02

	Title	Fig. 9. Contrast-enhanced chest CT scans (sagittal plane, soft tissue window, 1.0 mm slice thickness) reveal an uneven thickening of the walls of the middle third of the esophagus in a 52 mm long, the lumen of the esophagus is narrowed, fragmentary. Note: created by the authors
	Type	Исследовательские инструменты
	Date	2025-12-02

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Siberian journal of oncology

Concurrent incidence of esophageal squamous cell carcinoma and gastric adenocarcinoma: a report of three cases

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