HUMORAL IMMUNE RESPONSES TO EPSTEIN-BARR VIRUS IN PATIENTS WITH PRECANCEROUS GASTRIC LESIONS AND GASTRIC CANCER OF DIFFERENT HISTOTYPES
https://doi.org/10.21294/1814-4861-2016-15-5-40-46
Abstract
The paper presents the results of determining the concentration of specific antiviral immunoglobulins to viral antigens in blood serum of patients with gastric dysplasia (n=56) and gastric cancer (n=54), as well as the incidence of their titers depending on tumor location and histotype. In patients with precancerous gastric lesions, the increase in the IgG titer to Epstein Barr Virus (EBV) capsid antigen (VCA) and IgG to EBV early antigen (EA) in blood serum was found to be associated with enhancement of inflammatory activity. In patients with gastric cancer, high titers of IgG to VCA and IgG to EA were observed more frequently than in patients with gastric dysplasia, and the decrease in differentiation grade was followed by the increase in the concentration of IgG to EBV VCA. High titers (≥1:320) of IgG to VCA were found of patients with tumors located in the gastric body and cardia. High IgG titers to EBV VCA were shown to be associated with the presence of exophytic and ulcerated exophytic tumor growth.
About the Authors
M. V. Vusik
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Russia, Tomsk 5, Kooperativny Street, 634009-Tomsk
Russian Federation
Russian Federation
MD, DSc, Leading Researcher, Endoscopic Department, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences (Tomsk, Russian Federation)
R. I. Pleshko
Siberian State Medical University, Russia, Tomsk
Russian Federation
Russian Federation
MD, DSc, Professor of Department of Morphology and General Pathology, Siberian State Medical University (Tomsk, Russian Federation)
T. V. Avdeenko
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Russia, Tomsk 5, Kooperativny Street, 634009-Tomsk
Russian Federation
Russian Federation
MD, PhD, Physician, Endoscopy Department, Cancer Research Institute, Tomsk National Research Medical Center the Russian Academy of Sciences (Tomsk, Russian Federation)
O. V. Cheremisina
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Russia, Tomsk 5, Kooperativny Street, 634009-Tomsk
Russian Federation
Russian Federation
MD, DSc, Head of Endoscopy Department, Cancer Research Institute, Tomsk National Research Medical Center the Russian Academy of Sciences (Tomsk, Russian Federation)
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Review
For citations:
Vusik M.V., Pleshko R.I., Avdeenko T.V., Cheremisina O.V. HUMORAL IMMUNE RESPONSES TO EPSTEIN-BARR VIRUS IN PATIENTS WITH PRECANCEROUS GASTRIC LESIONS AND GASTRIC CANCER OF DIFFERENT HISTOTYPES. Siberian journal of oncology. 2016;15(5):40-46. (In Russ.) https://doi.org/10.21294/1814-4861-2016-15-5-40-46
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