CRYO-RADIOTHERAPY FOR LOCAL LYADVANCED RECURRENT SKIN CANCER OF THE FACE
https://doi.org/10.21294/1814-4861-2017-16-6-67-72
Abstract
The aim of the study was to improve the treatment outcomes for patients with locally advanced recurrent basal cell and squamous cell skin carcinomas of the face. Material and methods. A total of 26 patients with locally advanced recurrent basal cell (n=21) and squamous cell (n=5) skin carcinomas of the skin were treated with radiotherapy (2–2.5 Gy daily fractions to a total dose of 60–70 Gy, 5 days a week) in combination with local freezing of the tumor. Local cooling of the tumor to the temperature of tissue freezing was performed 10–15 minutes before each session of radiation therapy using liquid nitrogen cryo-preservation equipment. Patients with recurrent skin cancer who had received previously radiation therapy were not eligible for cryoradiotherapy. Results. Complete response was achieved in 23 (88.5 %) patients, residual tumors were removed by conventional surgery (n=2) and cryosurgery (n=1). At 2 to 14-year follow up, recurrences of skin cancer occurred in 3 (11.5 %) cases. Good aesthetic and functional results were observed. Conclusion. Cryo-radiotherapy was shown to be effective, providing long-term aesthetic and functional results.
About the Authors
I. N. Pustynskiy
N.N. Blokhin National Medical Research Cancer Center, Moscow;
N.I. Pirogov Russian National Research Medical University, Moscow
Russian Federation
Russian Federation
MD, DSc, Senior Researcher of Surgery Department № 4, Brach of Head and Neck Tumors
SPIN-code: 9947-7850
T. D. Tabolinovskaya
N.N. Blokhin National Medical Research Cancer Center, Moscow
Russian Federation
MD, PhD, Senior Researcher of Scientific and Organizational Department
Russian Federation
MD, PhD, Senior Researcher of Scientific and Organizational Department
S. I. Tkachev
N.N. Blokhin National Medical Research Cancer Center, Moscow
Russian Federation
Russian Federation
MD, DSc, Professor, Leading Researcher of Radiology Department
SPIN-code: 2150-6017
S. B. Alieva
N.N. Blokhin National Medical Research Cancer Center, Moscow
Russian Federation
MD, DSc, Leading Researcher of Radiology Department
Russian Federation
MD, DSc, Leading Researcher of Radiology Department
R. I. Azizian
N.N. Blokhin National Medical Research Cancer Center, Moscow
Russian Federation
MD, DSc, Professor, Head of Surgery Department № 4, Brach of Head and Neck Tumors
Russian Federation
MD, DSc, Professor, Head of Surgery Department № 4, Brach of Head and Neck Tumors
E. V. Kiva
N.I. Pirogov Russian National Research Medical University, Moscow
Russian Federation
MD, Postgraduate, Department of Oncology and Radiology, Faculty of Medicine
Russian Federation
MD, Postgraduate, Department of Oncology and Radiology, Faculty of Medicine
A. V. Egorova
N.I. Pirogov Russian National Research Medical University, Moscow
Russian Federation
MD, PhD, Professor of Department of Oncology an Radiology, Faculty of Medicine
Russian Federation
MD, PhD, Professor of Department of Oncology an Radiology, Faculty of Medicine
S. B. Peterson
N.I. Pirogov Russian National Research Medical University, Moscow
Russian Federation
MD, DSc, Professor, Head of Department of Oncology an Radiology, Faculty of Medicine
Russian Federation
MD, DSc, Professor, Head of Department of Oncology an Radiology, Faculty of Medicine
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Review
For citations:
Pustynskiy I.N., Tabolinovskaya T.D., Tkachev S.I., Alieva S.B., Azizian R.I., Kiva E.V., Egorova A.V., Peterson S.B. CRYO-RADIOTHERAPY FOR LOCAL LYADVANCED RECURRENT SKIN CANCER OF THE FACE. Siberian journal of oncology. 2017;16(6):67-72. (In Russ.) https://doi.org/10.21294/1814-4861-2017-16-6-67-72
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